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Flavonoids compound, preparation method and application thereof

A technology of flavonoids and drugs, applied in the preparation of sugar derivatives, chemical instruments and methods, sugar derivatives, etc., can solve the problems of not gaining weight, inhibiting skeletal muscle, and not using drugs for cachexia, etc., to achieve inhibition of inflammation , slow down the effect of skeletal muscle atrophy

Inactive Publication Date: 2014-11-26
SHANGHAI SIXTH PEOPLES HOSPITAL
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

Only progesterone preparations and glucocorticoid preparations are recommended for clinical application by the Nursing Branch of the American Cancer Society, and these two types of drugs, such as medroxyprogesterone and dexamethasone, only have the effect of improving appetite, and do not increase body weight or inhibit bones. Muscle; while others, such as protein-stimulating agents, thalidomide, betsifeline, etc., are not recommended for clinical application; there are no drugs used in clinical treatment of cachexia in natural medicine

Method used

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  • Flavonoids compound, preparation method and application thereof
  • Flavonoids compound, preparation method and application thereof
  • Flavonoids compound, preparation method and application thereof

Examples

Experimental program
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Embodiment 1

[0060] In this example, the molecular structure of flavonoids (referred to as FD-1 in this example) is as shown in (III):

[0061]

[0062] The FD-1 described in this example was purchased from Jiangsu Nantong Feiyu Co., Ltd., with a purity of >98% by HPLC.

[0063] Materials: FD-1 purchased in this example, HPLC purity>98%, accurately weighed 15mg and 5mg of FD-1, respectively, and dilute to 100mL phosphate buffered saline (PBS), the obtained concentrations were 150ppm and 50ppm respectively The two stock solutions (respectively denoted as F-H, F-L), mouse TNG-α and IL-6 cytokine kits were purchased from Shenzhen Dakwei Biological Co., Ltd., and other organic reagents in the experiment were commercially available products.

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Abstract

The invention provides a flavonoids compound, a preparation method and an application of the flavonoids compound in medicine for prevention and treatment of cachexia. The compound has a structure shown in a structural formula (I) as follows. The provided flavonoids compound can be used for preparing the medicine for treating human and animal cachexia, and cachexia relative to a plurality of diseases can be treated, lowered body weight due to skeletal muscle atrophy and fat degradation atrophy can be effectively alleviated, tumour burden can be obviously mitigated, protein degradation is inhibited, and cytokine TNF-a and IL-6 level can be increased.

Description

technical field [0001] The invention relates to a flavonoid compound and its preparation method and application, in particular to a flavonoid compound for preventing and treating cachexia, its preparation method and application. Background technique [0002] Cachexia is a multi-organ syndrome characterized by weight loss, muscle atrophy, and adipose tissue wasting, often accompanied by various chronic diseases, such as cancer, tuberculosis, diabetes, chronic obstructive pulmonary disease, chronic kidney disease, heart failure, infection Disease and acquired immunodeficiency syndrome, its progressive weight loss and muscle tissue atrophy can not be reversed by conventional nutritional support, resulting in progressive body dysfunction; clinical manifestations of anorexia, weight loss, anemia and muscle atrophy, which lead to the death of patients The quality is reduced and the duration of survival is significantly shortened, and the normal course of treatment of the disease i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P35/00A61P3/10A61P31/00A61P31/06A61P5/00A61P11/00A61P13/12A61P9/04A61P31/18A61P7/00A61P29/00A61P21/00C07H17/07C07H1/08
Inventor 郭澄万丽丽李斌
Owner SHANGHAI SIXTH PEOPLES HOSPITAL
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