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Phenylethyl resorcinol-cladded nano-solid lipid carrier and preparation method thereof

A technology of phenylethylresorcinol and solid lipid, applied in the field of phenylethylresorcinol, nano-solid lipid carrier coated with phenylethylresorcinol and its preparation, can solve the problem of lipid carrier Problems such as uneven dispersion, unfavorable penetration of active ingredients, and complicated operation of lipid carriers can achieve the effects of improving coating rate and stability, improving utilization rate, and enhancing affinity

Inactive Publication Date: 2014-11-19
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] In view of the above technical problems in the prior art, the invention provides a nano solid lipid carrier coated with phenylethylresorcinol and a preparation method thereof, the described nanometer solid lipid carrier coated with phenylethylresorcinol The nano solid lipid carrier and preparation method should solve the complex operation of the lipid carrier prepared by the high-pressure homogenization method in the prior art, which is easy to destroy the structure; and the lipid carrier prepared by the ordinary emulsification method is not uniformly dispersed, has a large particle size, and is not uniform. Technical issues that facilitate the penetration of active ingredients

Method used

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  • Phenylethyl resorcinol-cladded nano-solid lipid carrier and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] A nanometer solid lipid carrier coated with phenylethylresorcinol, calculated according to the total amount of 100g, its composition and content are as follows:

[0043] Phenylethylresorcinol 0.1g (0.1%)

[0044] Phospholipids 0.5g (0.5%)

[0045] Solid Fat 2g (2%)

[0046] Liquid Lipid 3g ( 3%)

[0047] Solid emulsifier 2g (2%)

[0048] Polyol 5g (5%)

[0049] Inorganic salt 0.1g(0.1%)

[0050] Preservatives 0.01g(0.01%)

[0051] The balance is deionized water

[0052] Described phenylethylresorcinol is a whitening agent;

[0053] Described phospholipid is soybean lecithin;

[0054] Described solid lipid is glyceryl monostearate;

[0055] The liquid lipid is caprylic acid / capric triglyceride;

[0056] Described solid emulsifier is steareth-21 and steareth-2 composite;

[0057] Described polyhydric alcohol is glycerol;

[0058] Described inorganic salt is sodium chloride;

[005...

Embodiment 2

[0072] A nano-solid lipid carrier coated with phenylethyl resorcinol, calculated according to the total amount of 100g, its composition and content are as follows:

[0073] Phenylethylresorcinol 1g (1%)

[0074] Phospholipids 1g(1%)

[0075] Solid Fat 5g (5%)

[0076] Liquid Lipid 6g ( 6%)

[0077] Solid emulsifier 6g (6%)

[0078] Polyol 8g (8%)

[0079] Inorganic salt 0.3g(0.3%)

[0080] Preservatives 0.03g (0.03%)

[0081] The balance is deionized water

[0082] Described phenylethylresorcinol is a whitening agent;

[0083] Described phospholipid is egg yolk phospholipid;

[0084] The solid lipid is cetostearyl alcohol;

[0085] The liquid lipid is isooctyl palmitate;

[0086] Described solid emulsifier is ceteareth-20;

[0087] Described polyhydric alcohol is propylene glycol;

[0088] Described inorganic salt is sodium chloride;

[0089] The preservative is diazoalkyluria;

[0090] The preparat...

Embodiment 3

[0092] A nano-solid lipid carrier coated with phenylethyl resorcinol, calculated according to the total amount of 100g, its composition and content are as follows:

[0093] Phenylethylresorcinol 4g (4%)

[0094] Phospholipids 1.5g (1.5%)

[0095] Solid Fat 10g (10%)

[0096] Liquid Lipid 10g ( 10%)

[0097] Solid emulsifier 10g (10%)

[0098] Polyol 12g (12%)

[0099] Inorganic salt 0.5g (0.5%)

[0100] Preservatives 0.6g (0.6%)

[0101] The balance is deionized water

[0102] Described phenylethylresorcinol is a whitening agent;

[0103] Said phospholipids are hydrogenated phospholipids;

[0104] The solid lipid is cetyl palmitate;

[0105] Described liquid lipid is isopropyl palmitate;

[0106] Described solid emulsifier is ceteareth-25;

[0107] Described polyhydric alcohol is 1,3-butanediol;

[0108] Described inorganic salt is potassium chloride;

[0109] Described preservative is gly...

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Abstract

The invention provides a phenylethyl resorcinol-cladded nano-solid lipid carrier. The carrier is prepared from the following components in percentage by weight: 0.1-10 percent of phenylethyl resorcinol, 0.5-5 percent of phospholipid, 2-15 percent of solid lipid, 3-20 percent of liquid lipid, 2-15 percent of solid emulsifier, 5-20 percent of polyol, 0.1-0.8 percent of inorganic salt, 0.01-0.8 percent of preservative and the balance of deionized water. The invention further provides a method for preparing the nano-solid lipid carrier, which comprises the following steps: melting and uniformly dispersing an oil phase consisting of the phenylethyl resorcinol, the phospholipid, the solid lipid, the liquid lipid and the solid emulsifier to obtain an oil phase; heating a water phase consisting of the polyol, the inorganic salt and the deionized water; homogenizing the water phase, adding the oil phase, uniformly mixing, and performing ultrasonic treatment; and stirring and cooling to form the phenylethyl resorcinol-cladded nano-solid lipid carrier. The phenylethyl resorcinol-cladded nano-solid lipid carrier is capable of promoting permeability of phenylethyl resorcinol on skin, and improving the whitening effect.

Description

technical field [0001] The invention belongs to the field of chemical industry, and in particular relates to a phenylethylresorcinol, specifically a nanometer solid lipid carrier coated with phenylethylresorcinol and a preparation method thereof. Background technique [0002] With the improvement of living standards, more and more people have higher requirements for skin care, and fair skin has always been advocated by oriental women. The color of the skin mainly depends on the amount of melanin produced by the pigment cells of the epidermis and its distribution in the outermost layer of the skin. Affected by many factors, it is oxidized into dopa, dopaquinone, dopachrome, 5,6. Dioxindole, indole-5, 6-quinone, etc., are finally converted into pigment particles. Whitening agents mainly reduce the production of melanin by inhibiting the rate-limiting enzyme tyrosinase activity, blocking enzyme activity or blocking melanin oxidation pathway. [0003] The main whitening agent...

Claims

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Application Information

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IPC IPC(8): A61K8/34A61K8/92A61K8/86A61Q19/02
Inventor 张婉萍贾方雅朱海洋刘晓慧
Owner SHANGHAI INST OF TECH
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