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Method for preparing aucubin monomer from eucommia ulmoides fruit

The invention relates to a technology of aucubin and a processing method, which are applied in the field of medicine and can solve the problems of unfavorable industrial production, development and utilization of aucubin monomer, long industrial production cycle, large consumption of reagents, and the like, so as to improve the comprehensive utilization rate. , to achieve the effect of effective use and easy operation

Active Publication Date: 2014-10-29
CHANGSHA DUXACT BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent 201010297478.7 discloses "a process for extracting aucubin from Eucommia ulmoides", which mainly includes flash or ultrasonic extraction, macroporous resin adsorption and purification, but the purity of aucubin obtained by this process is only 50% , and the consumption of reagents is large, the operation is cumbersome, the industrial production cycle is long, and the cost is high, which is not conducive to the industrial production, development and utilization of aucubin monomer
The method separates and obtains aucubin with a polymer packing stationary phase chromatographic column, silica gel column chromatography, and recrystallization, and the steps are numerous and the product yield is low (the yields in the examples are respectively 0.955% and 2.5%), Longer production cycle

Method used

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  • Method for preparing aucubin monomer from eucommia ulmoides fruit
  • Method for preparing aucubin monomer from eucommia ulmoides fruit
  • Method for preparing aucubin monomer from eucommia ulmoides fruit

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Shell the eucommia fruit, crush the nuts to 40 mesh, take 10kg and put it into the extraction tank, add 60L petroleum ether to degrease, degrease twice, each time for 3 hours, and filter out the dregs as degreasing coarse material. Add 80L of ethanol to ultrasonically extract the defatted crude material for 2 hours, extract 3 times, and combine the extracts. The extract was concentrated under reduced pressure at 40°C to 1 / 8 of the original volume and ethanol was recovered. The concentrated solution was saturated with acetone and dissolved, crystallized at 7°C for 48 hours, and the crude crystals were saturated with ethyl acetate and dissolved. Get 10L silica gel packing column, add saturated liquid to silica gel column, use 3BV ethyl acetate (mass ratio ethyl acetate:methanol=1:0) successively, 4BV10:1 ethyl acetate / methanol (mass ratio ethyl acetate:methanol= 10:1), 5BV6:1 ethyl acetate / methanol (mass ratio ethyl acetate:methanol=6:1), 4BV4:1 ethyl acetate / methanol so...

Embodiment 2

[0037]Shell the eucommia fruit, crush the nuts to 50 mesh, take 10kg and put it into the extraction tank, add 80L petroleum ether to degrease, degrease 3 times, each time for 4 hours, filter out the dregs as degreasing coarse material. Add 100L of ethanol to ultrasonically extract the defatted crude material for 4 hours, extract 5 times, and combine the extracts. The extract was concentrated under reduced pressure at 40°C to 1 / 10 of the original volume and ethanol was recovered. The concentrated solution was saturated with acetone and dissolved, crystallized at 4°C for 72 hours, and the crude crystals were saturated with ethyl acetate and dissolved. Get 10L silica gel packing column, add saturated liquid to silica gel column, use 3BV ethyl acetate (mass ratio ethyl acetate:methanol=1:0) successively, 4BV10:1 ethyl acetate / methanol (mass ratio ethyl acetate:methanol= 10:1), 5BV6:1 ethyl acetate / methanol (mass ratio ethyl acetate:methanol=6:1), 4BV4:1 ethyl acetate / methanol sol...

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Abstract

The invention relates to the technical field of medicines, and in particular provides a method for preparing an aucubin monomer from eucommia ulmoides fruit. The method comprises the following steps: shucking the eucommia ulmoides fruit serving as raw material; crushing the kernels; degreasing by using petroleum ether; extracting with ethanol; adding acetone, cooling and crystallizing; purifying by using a silicagel column; and concentrating, thus obtaining the high-purity aucubin monomer. The method provided by the invention is safe in production process, low in toxicity and low in energy consumption, can put into industrial production easily, has the advantages of high purity, high yield and stable quality, can meet the requirements of development of medicine mainly prepared from the eucommia ulmoides fruit, can realize the comprehensive utilization of the eucommia ulmoides resource, and therefore increases the value of eucommia ulmoides in the fields of medical treatment and healthcare.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a process for preparing aucubin monomer from eucommia ulmoides, which can meet the needs of drug development with eucommia ulmoides as the main raw material, improve the comprehensive utilization of eucommia resources, and enhance the effectiveness of eucommia ulmoides Development and utilization value in the field of medical and healthcare. Background technique [0002] Aucubin (aucubin, AU) belongs to the iridoid glycosides, the molecular formula is C 15 h 22 o 9 , molecular weight 346.33, melting point 181°C, easily soluble in polar solvents such as water, methanol and ethanol, almost insoluble in weak polar solvents such as chloroform, ether and petroleum ether. This compound mainly exists in plants such as Eucommia ulmoides Oliver, Cornaceae plant Aucubachinensis, Plantago plant Plantago and other plants. It has many pharmacological activities such as liver ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07H17/04C07H1/08
Inventor 冯晗郭成贤严谨黄卫华
Owner CHANGSHA DUXACT BIOTECH CO LTD
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