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Medicinal composition containing puerarin and preparation thereof

A composition and puerarin technology, applied in the field of medicine, can solve the problems of serious intravascular hemolysis adverse reactions, affecting the therapeutic effect of puerarin, restricting the clinical application of puerarin, etc., achieving easy industrialized production, low production cost, and convenient storage and transportation. Effect

Inactive Publication Date: 2014-10-29
北京美迪康信医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The published invention patent "Puerarin Pharmaceutical Composition and Its Preparation" discloses a pharmaceutical composition and formula that can reduce the toxic and side effects of propylene glycol. Improve the solubility of puerarin, so that the required drug concentration can be achieved, but at the same time, puerarin reacts with alkaline substances to form a salt, which not only makes the aqueous solution yellow and discolored, affects the quality of the product, but also affects the therapeutic effect of puerarin
In addition, the adverse reactions of intravascular hemolysis during the clinical use of commercially available puerarin injections are more serious, which also limits the clinical application of puerarin.

Method used

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  • Medicinal composition containing puerarin and preparation thereof
  • Medicinal composition containing puerarin and preparation thereof
  • Medicinal composition containing puerarin and preparation thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Under clean conditions, put 5g of glycine into the liquid dispensing device, add 800ml of water for injection and stir to dissolve, cool to room temperature, add sodium hydroxide, adjust the pH to 10.0, blow in nitrogen, add 30g of puerarin and stir for about 30min to make it Completely dissolve, add 40g dextran 60 to dissolve, add 0.3% needle with carbon and stir evenly to absorb the heat source, filter to decarbonize, add water to a sufficient amount, filter through a 0.22μm microporous membrane to obtain a 30mg / ml puerarin solution. Dispense 2.5ml into ampoules, freeze-dry for 72 hours to make sterile freeze-dried powder injection. Specification 30mg / bottle.

Embodiment 2

[0071] Under clean conditions, put 10g of glycine into the liquid dispensing device, add 800ml of water for injection and stir to dissolve, cool to room temperature, add sodium hydroxide, adjust the pH to 10.5, blow in nitrogen, add 30g of puerarin and stir for about 30min to make it Completely dissolve, add 40g dextran 60 to dissolve, add 0.3% needle with carbon and stir evenly to absorb the heat source, filter to decarbonize, add water to a sufficient amount, filter through a 0.22μm microporous membrane to obtain a 30mg / ml puerarin solution. Dispense 2.5ml into ampoules, freeze-dry for 72 hours to make sterile freeze-dried powder injection. Specification 30mg / bottle.

Embodiment 3

[0073] Under clean conditions, put 15g of glycine into the liquid dispensing device, add 800ml of water for injection and stir to dissolve, cool to room temperature, add sodium hydroxide, adjust the pH to 11, feed nitrogen, add 30g of puerarin and stir for about 30min to make it Completely dissolve, add 50g dextran 60 solution, add 0.3% needle with carbon and stir evenly to absorb the heat source, filter to decarbonize, add water to a sufficient amount, filter through a 0.22μm microporous membrane to obtain a 30mg / ml puerarin solution. Dispense 2.5ml into ampoules, freeze-dry for 72 hours to make sterile freeze-dried powder injection. Specification 30mg / bottle.

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Abstract

The invention belongs to the technical field of medicines, and provides a medicinal composition containing puerarin and a preparation thereof. The medicinal composition comprises the following components in parts by weight: (a) 30-60 parts of puerarin, (b) 5-30 parts of sodium glycinate or / and glycine and (c) 15-100 parts of dextran 60. A lyophilizing powder preparation prepared from the composition has good solubility, high stability and good re-solubility and is convenient to use, store and transport; and the preparation method is simple, is easy for industrial production and has low production cost.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition containing puerarin and its preparation. Background technique [0002] Pueraria lobata (Willd.) Ohwi is the dried root of Pueraria lobata (Willd.) Ohwi, a leguminous plant. It is commonly known as Pueraria lobata. It is a commonly used traditional Chinese medicine. The effect of poison. Puerarin contains a variety of active ingredients. Isoflavones are one of the main components of Puerarin, and Puerarin is the main active ingredient of this genus. Puerarin has a wide range of pharmacological effects, including lowering blood fat, anti-inflammation, anti-arrhythmia, protective effect on myocardial ischemia, renal protection, anti-oxidation, anti-ischemia-reperfusion injury, anti-hepatic ischemia-reperfusion injury, anti-alcohol Central inhibition, regulation of bone metabolism, hypoglycemic, diuretic and other effects. [0003] Current...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/18A61K31/352A61K9/19
Inventor 刘实
Owner 北京美迪康信医药科技有限公司
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