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Method for building rat spinal cord injury model

A spinal cord injury and model building technology, applied in medical science, veterinary instruments, veterinary surgery, etc., can solve the problems of complicated spinal cord injury model operation, large amount of bleeding in rats, high infection death, etc., and achieves good prospects for popularization and use. Significant dysfunction and low chance of infection

Inactive Publication Date: 2014-10-29
SHANXI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The present invention overcomes the deficiencies of the prior art, and the technical problems to be solved are many problems such as complex operation and poor repeatability in the prior art spinal cord injury model, large amount of bleeding in rats, high infection death rate, many complications, short survival time, etc. Furthermore, a method for establishing a rat spinal cord injury model with simple operation, good repeatability, and significant dysfunction is provided.

Method used

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  • Method for building rat spinal cord injury model
  • Method for building rat spinal cord injury model
  • Method for building rat spinal cord injury model

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0038] The present invention will be further described below in conjunction with specific examples.

[0039] Modeling method:

[0040] (1) Weigh the rats, and inject 1% pentobarbital sodium injection into the intraperitoneal cavity at a rate of 0.4ml per 100g body weight.

[0041] (2) After the rats were anesthetized, the back skin was prepared and the skin was disinfected.

[0042] (3) Determine the position of T9-T12. The lumbar spinous process of SD rats is prominent, and the thoracic spinous process is tilted backward, and the lumbar spinous process is tilted forward. According to this mark, it is easy to locate accurately. Make an incision just above T9-T12, make a 2-3cm skin incision, separate muscle and fascia, and expose T9-T12 spinous process and lamina.

[0043] (4) if image 3 The muscles and ligaments on the left side of the T9-T10 spinous process were peeled off with tissue scissors and mosquito forceps as shown to thoroughly expose the T9-T10 spinous process a...

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Abstract

The invention relates to a new method for building a rat spinal cord injury model. The method mainly solves the problems that in an existing model, operation is complex, the repeatability is poor, the amount of bleeding of a rat is large, the infection death rate is high, numerous complications are caused and the survival time of the rat is short. According to the technical scheme, unilateral lumbar cord dividing injury is made at the accurate position of the spinal cord of the rat through a homemade syringe needle without opening a medullary space, the spinal cord injury model is built according to the new method, and medicine and preparations can be injected at the same time of making the injury to interfere in the injury and the regeneration and repair process after the injury.

Description

technical field [0001] The invention relates to a method for establishing a spinal cord injury model, in particular to a method for establishing a rat spinal cord injury model. Background technique [0002] Spinal cord injury is a disease with a high morbidity rate. It is an unresolved problem in clinical practice and can cause irreversible motor sensory dysfunction. With the rapid development of various industries in society, the incidence of spinal cord injury has also increased. Therefore, the research and attention to spinal cord injury is still a subject of joint exploration at home and abroad. The spinal cord injury model provides a scientific basis for the study of spinal cord injury. An ideal spinal cord injury model should meet the following conditions. 1. It should be able to reflect the neurophysiology and motor behavior of spinal cord injury in experimental animals. 2. An animal model consistent with or similar to clinical spinal cord injury can be provided, ...

Claims

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Application Information

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IPC IPC(8): A61D1/00A61D7/00
Inventor 李夏青齐超王志茹王晨亮张宏
Owner SHANXI MEDICAL UNIV
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