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Novel application of magnetic Prussian blue nanoparticles to cancer targeting diagnosis and treatment

A technology of Prussian blue and nanoparticles, applied in the field of biomaterials, achieves good magnetic targeting effect, simple preparation method and high relaxation rate

Inactive Publication Date: 2014-10-15
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the use of readily available materials such as magnetic Prussian blue nanoparticles for targeted cancer therapy has not been reported

Method used

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  • Novel application of magnetic Prussian blue nanoparticles to cancer targeting diagnosis and treatment
  • Novel application of magnetic Prussian blue nanoparticles to cancer targeting diagnosis and treatment
  • Novel application of magnetic Prussian blue nanoparticles to cancer targeting diagnosis and treatment

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Prepare magnetic Prussian blue nanoparticles according to existing methods, and the specific preparation method is as follows:

[0033] A. Potassium ferrocyanide (K 4 [Fe(CN) 6 ]) Solution preparation

[0034] A certain amount of K 4 [Fe(CN) 6 ] Dissolve the solid in water and adjust its pH so that K 4 [Fe(CN) 6 ] at a concentration of 0.002M and a pH of 3.

[0035] B. Iron tetroxide (Fe 3 o 4 ) Preparation of nanosuspension

[0036] A certain amount of Fe 3 o 4 The powder is dissolved in water and its pH value is adjusted so that Fe 3 o 4 The concentration of the suspension is 10mg / mL, and the pH value is 5.

[0037] C. Hydrogen peroxide (H 2 o 2 ) and ferric chloride (FeCl 3 ) Preparation of mixed solution

[0038] A certain amount of H 2 o 2 and FeCl 3 The aqueous solution is mixed and its pH value is adjusted so that H 2 o 2 The concentration is 0.3%, FeCl 3 The concentration is 0.002M, and the pH value is 3.

[0039] D. Synthesis of therapeu...

Embodiment 2

[0045] Some adjustments are made to the existing method for preparing magnetic Prussian blue nanoparticles, and the specific preparation method is as follows:

[0046] A. Potassium ferrocyanide (K 4 [Fe(CN) 6 ]) Solution preparation

[0047] A certain amount of K 4 [Fe(CN) 6 ] Dissolve the solid in water and adjust its pH so that K 4 [Fe(CN) 6 ] at a concentration of 0.001M and a pH of 3.

[0048] B. Iron tetroxide (Fe 3 o 4 ) Preparation of nanosuspension

[0049] A certain amount of Fe 3 o 4 The powder is dissolved in water and its pH value is adjusted so that Fe 3 o 4 The concentration of the suspension is 10mg / mL, and the pH value is 5.

[0050] C. Hydrogen peroxide (H 2 o 2 ) and ferric chloride (FeCl 3 ) Preparation of mixed solution

[0051] A certain amount of H 2 o 2 and FeCl 3 The aqueous solution is mixed and its pH value is adjusted so that H 2 o 2 The concentration is 0.3%, FeCl 3 The concentration is 0.001M, and the pH value is 3.

[0052]...

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Abstract

The invention relates to development of novel application of existing magnetic Prussian blue nanoparticles to magnetic resonance imaging and targeting photothermal therapy for cancer. Magnetic Prussian blue is a traditional nano material and mainly comprises ferroferric oxide nano cores and Prussian blue nano shells. Prussian blue is an efficient near infrared light heat agent, and a clinical medicine with high biological safety in vivo. Ferroferric oxide has good magnetic resonance imaging and magnetic targeting effects, and has also been applied to the clinic. The existing preparation method of magnetic Prussian blue nanoparticles is mature, simple, green and low in cost. The invention develops novel application of magnetic Prussian blue nanoparticles to magnetic resonance imaging and targeting photothermal therapy for cancer, achieves the integration of utilization of the magnetic Prussian blue nanoparticles to targeting diagnosis and treatment for cancer, and has extremely broad application prospect in diagnosis and treatment of cancer.

Description

Technical field: [0001] The invention belongs to the technical field of biomaterials, and specifically relates to the development of existing magnetic Prussian blue nanoparticles into a novel cancer-targeted diagnosis and treatment agent, which is simultaneously used for nuclear magnetic resonance imaging and targeted photothermal ablation therapy of cancer. technical background: [0002] Cancer diagnosis and treatment technology is a tumor-killing technology that integrates diagnosis and treatment. Killing technologies for cancer treatment (such as chemotherapy, gene therapy, photodynamic therapy, photothermal therapy, etc.) are based on a nanomaterial, so as to realize the simultaneous diagnosis and treatment of cancer. Compared with individual cancer diagnosis technology and cancer treatment technology, cancer diagnosis and treatment technology has the advantage of being able to locate the location and size of the tumor in real time during cancer treatment, so as to bette...

Claims

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Application Information

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IPC IPC(8): A61K49/18A61K49/06A61K41/00A61P35/00
Inventor 戴志飞付光磊刘伟
Owner PEKING UNIV
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