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Novel application of polypyrrole nanoparticle as contrast agent for photoacoustic imaging

A polypyrrole nanometer and photoacoustic imaging technology, which is applied in the field of biomedical materials, can solve the problems of biocompatibility and stability in the synthesis process of low photothermal conversion efficiency, and achieve efficient and stable near-infrared photothermal effect, size controllable, Efficient and stable absorption effect

Inactive Publication Date: 2014-10-15
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

There are still many obstacles in the application of these organic compounds, such as low photothermal conversion efficiency or complicated synthesis process to achieve good biocompatibility and stability, thus limiting their further application.

Method used

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  • Novel application of polypyrrole nanoparticle as contrast agent for photoacoustic imaging
  • Novel application of polypyrrole nanoparticle as contrast agent for photoacoustic imaging
  • Novel application of polypyrrole nanoparticle as contrast agent for photoacoustic imaging

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Setup of experimental device: Q-switched Nd:YAG laser (LS-2137 / 2, LOTIS TII, Minsk, Belarus) and pump adjustable Ti sapphire laser (LT-2211A, LOTIS TII, Minsk, Belarus) were used in the experiment The photoacoustic signal is generated as the excitation light source, and the laser is uniformly irradiated on the test sample through the ground glass. In the experiment, an 808nm near-infrared pulsed laser with a pulse frequency of 10Hz was selected, and the intensity of the incident light irradiated on the surface of the test sample was controlled to be lower than 10mJ cm -2 . In the experiment, a 2.25MHz unfocused ultrasonic probe was used to detect the ultrasonic signal generated by the test sample. In order to reduce the attenuation of the ultrasonic signal, both the test sample and the probe were immersed in a water tank, and a stepping motor was used to make the ultrasonic probe rotate horizontally around the test sample in a circle with a radius of 12 cm. The experi...

Embodiment 2

[0023]Preparation of polypyrrole nanoparticles (PPy NPs): Weigh 1.5g PVA into 20mL deionized water, heat to 60°C, and return to room temperature and stir after it is fully dissolved. Weigh 1.24338g FeCl3·6H2O into the above system and stir for 1h, then place in an ice-water bath and stir, add 140μL of pyrrole monomer, and react for 4h. After the reaction, stable dispersed PPy NPs were obtained by centrifugation. The absorption spectrum of the obtained nanoparticles is shown in the attached figure 2 a, shows that polypyrrole nanoparticles have strong absorption in the wavelength range of 650-900nm, and the transmission electron microscope shows that its particle size is about 46nm (attached figure 2 b).

Embodiment 3

[0025] Prepare different concentrations of polypyrrole nanoparticles (120μg / mL, 100μg / mL, 80μg / mL, 60μg / mL, 50μg / mL, 40μg / mL, 30μg / mL, 20μg / mL, 10μg / mL) and irradiate with 808nm pulsed laser Next, the device of Example 1 was used to detect the photoacoustic signal generation ability of the sample. The experimental results show that polypyrrole nanoparticles have excellent responsiveness to 808nm pulsed laser, and the intensity of the generated photoacoustic signal increases linearly with the increase of the concentration of polypyrrole nanoparticles (attached image 3 ), which proves that polypyrrole nanoparticles have the potential as a contrast agent for photoacoustic imaging.

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Abstract

The invention discloses novel application of a polypyrrole nanoparticle as a contrast agent for photoacoustic imaging. The polypyrrole nanoparticle comprises solid, mesoporous and hollow structures, shows strong absorption capability in a near-infrared area with wavelength of 500 to 1300 nm and is a high-efficiency near-infrared light thermit. Application of the polypyrrole nanoparticle as the contrast agent for photoacoustic imaging can effectively improve penetration depth of near-infrared laser in tissue, and the polypyrrole nanoparticle has a substantial contrast enhanced effect. Moreover, a polypyrrole nano-material has high conductivity, excellent stability and good biocompatibility; a preparation method for the polypyrrole nanoparticle is simple and green and has low cost; as the contrast agent for photoacoustic imaging, the polypyrrole nanoparticle has wide application prospects.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to the new application of polypyrrole nanoparticles as photoacoustic imaging contrast agents. technical background [0002] Photoacoustic imaging is a newly emerging non-invasive imaging technology in recent years. It mainly reconstructs imaging by measuring the ultrasonic waves generated by biological tissue after absorbing pulsed laser. Due to the selectivity of pulsed lasers and the high resolution of ultrasound detection, photoacoustic imaging can be used to accurately image the structure and function of tissues, such as brain structure and function imaging, breast cancer imaging, and monitoring of tumor angiogenesis. Compared with other optical imaging techniques, such as confocal microscopy and optical coherence tomography, photoacoustic imaging can perform high-resolution imaging of deeper tissues. However, due to the serious scattering effect of light in tiss...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00
Inventor 戴志飞查正宝梁晓龙王金锐李长辉邓梓健李妍妍王淑敏曲恩泽
Owner PEKING UNIV
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