Tablet capsule filled with omeprazole tablet and sodium bicarbonate tablet

A technology of sodium bicarbonate tablets and omeprazole tablets, applied in capsule delivery, medical preparations containing active ingredients, digestive system, etc., can solve problems such as disorderly disintegration, reduced efficacy, failure, etc., and achieve enhanced compliance Enhanced performance, stability, and easy processing

Inactive Publication Date: 2014-10-15
HEILONGJIANG FUHE HUAXING PHARMA GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The disadvantages of the above-mentioned capsules are that omeprazole and sodium bicarbonate exist in the same capsule, which has the following disadvantages: 1. The two may come into contact outside the body, which leads to (1) due to the uniformity of multi-component mixing (2) During product testing, it is difficult to determine the content of each component due to mutual interference, which affects the qualitative and quantitative analysis results; (3) During long-term storage, due to possible chemical compatibility changes between components, it is easy to produce By-products, reducing effects or increasing side effects, product stability is not ideal
2. Because omeprazole and sodium bicarbonate are made into granules, they cause disordered disintegration in the stomach, so that when omeprazole disintegrates, the local part neutralized by sodium bicarbonate has failed

Method used

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  • Tablet capsule filled with omeprazole tablet and sodium bicarbonate tablet
  • Tablet capsule filled with omeprazole tablet and sodium bicarbonate tablet
  • Tablet capsule filled with omeprazole tablet and sodium bicarbonate tablet

Examples

Experimental program
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Effect test

Embodiment 1

[0025] Embodiment 1: see attached Figure 1-3 As shown, a capsule is filled with one omeprazole tablet; two sodium bicarbonate tablet capsules. The capsule specification is size 0. The capsule shell is composed of a lower capsule body 1 and an upper capsule body 2 set, and is equipped with the above three cylindrical tablets coated with different colors, which are omeprazole tablet 4 (containing omeprazole 20mg), the first bicarbonate Sodium tablet 3 (containing 550mg of sodium bicarbonate, made of microcrystalline cellulose, starch, lactose, pregelatinized starch slurry, plus sodium carboxymethyl starch, magnesium stearate and silicon dioxide) and the second sodium bicarbonate tablet (Contains 550mg of sodium bicarbonate, made of microcrystalline cellulose, starch, lactose, pregelatinized starch slurry, plus sodium carboxymethyl starch, magnesium stearate and silicon dioxide).

[0026] The first sodium bicarbonate tablet is a yellow film-coated tablet, the omeprazole tablet...

Embodiment 2

[0027] Embodiment 2: see attached Figure 4 As shown, a capsule filled with one omeprazole tablet; three tablets of sodium bicarbonate in the capsule. The capsule specification is size 0. The capsule shell is composed of a lower capsule body 1 and an upper capsule body 2 set, and is equipped with the above four cylindrical tablets coated with different colors, which are omeprazole tablet 4 (containing omeprazole 20mg), the first bicarbonate Sodium tablet 3 (containing 366.7 mg of sodium bicarbonate, made of mannitol, lactose, and talc powder), second sodium bicarbonate tablet 5 (containing 366.7 mg of sodium bicarbonate, made of microcrystalline cellulose, starch, lactose, pregelatinized Starch slurry, plus sodium carboxymethyl starch, magnesium stearate and silicon dioxide) and the third sodium bicarbonate tablet 6 (containing 366.7 mg of sodium bicarbonate).

[0028] The first and sodium bicarbonate tablets are yellow film-coated tablets, the omeprazole tablets are plain t...

Embodiment 3

[0029] Embodiment 3: basically with embodiment 2, a kind of capsule is filled with an omeprazole tablet; Three sodium bicarbonate tablet capsules. The capsule specification is size 0. The capsule shell is composed of a lower capsule body 1 and an upper capsule body 2 set, and is equipped with the above four cylindrical tablets coated with different colors, which are omeprazole tablet 4 (containing omeprazole 20mg), the first bicarbonate Sodium tablet 3 (containing 366.7 mg of sodium bicarbonate, made of microcrystalline, starch, lactose, pregelatinized starch slurry, plus sodium carboxymethyl starch, magnesium stearate and silicon dioxide), the second sodium bicarbonate tablet 5 (containing sodium bicarbonate 366.7mg) and the third sodium bicarbonate tablet 6 (containing sodium bicarbonate 366.7mg).

[0030] The first and sodium bicarbonate tablets are purple film-coated tablets, the omeprazole tablets are red enteric-coated tablets, and the second sodium bicarbonate tablets ...

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PUM

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Abstract

The invention relates to an oral hard capsule, particularly relates to a tablet capsule filled with omeprazole tablets and sodium bicarbonate tablets. The tablet capsule provided by the invention is composed of a capsule and tablets in the capsule. The capsule comprises an upper capsule body and a lower capsule body, and is filled with at least one tablet with active ingredient of omeprazole and at least one tablet with active ingredient of sodium bicarbonate. The invention has the beneficial effect that each sodium bicarbonate small tablet rapidly disintegrates, and regions with high intragastric pH value form rapidly around each sodium bicarbonate small tablet; due to ordered pH increase of the above regions, the omeprazole tablet obtains suitable pH value environment, which is not easily damaged by gastric acid, during disintegration.

Description

technical field [0001] The invention relates to an oral hard capsule, in particular to a tablet capsule filled with omeprazole tablets and sodium bicarbonate tablets. Background technique [0002] The U.S. FDA has approved the compound immediate-release proton pump inhibitor Omeprazole Sodium Bicarbonate Capsules (trade name: Zegerid) from Santarus, with specifications including 40mg / 1100mg and 20mg / 1100mg. The mechanism of action of this compound immediate-release drug is: after oral administration, sodium bicarbonate can cause the pH in the stomach to rise rapidly, thereby protecting the uncoated omeprazole from being degraded by gastric acid in the stomach, which also temporarily stimulates gastric antrum G The cells secrete gastrin. Oral administration of sodium bicarbonate solution can lead to an increase in circulating gastrin levels within 30 minutes. Elevated levels of circulating gastrin stimulate the total number of parietal cells and H + / K + - ATPase function...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/00A61K9/48A61P1/04A61K31/4439
Inventor 吴光彦
Owner HEILONGJIANG FUHE HUAXING PHARMA GROUP
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