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Caffeic acid derivate, and preparation method and application thereof

A compound and acid technology, applied in the field of caffeic acid derivative compounds and their preparation, can solve problems such as no research reports on secondary metabolites

Active Publication Date: 2014-10-08
GUANGXI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

As a mangrove tree species widely distributed in South China, A. chinensis is widely distributed. So far, there has been no research report on secondary metabolites in A. chinensis fruit, let alone caffeic acid with antioxidant activity obtained from A. chinensis fruit. Class Derivative Compound Reports

Method used

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  • Caffeic acid derivate, and preparation method and application thereof
  • Caffeic acid derivate, and preparation method and application thereof
  • Caffeic acid derivate, and preparation method and application thereof

Examples

Experimental program
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Embodiment Construction

[0015] (1) Preparation of caffeic acid derivative compound Marilide A

[0016] The fruit of A. chinensis (wet weight about 20.0kg) was chopped, soaked and extracted three times with 20L of 95% industrial alcohol at room temperature, soaked for one week each time, and obtained a total of 55L of extracts, which were concentrated under reduced pressure (0.09MPa, 50°C) to obtain Extract 2.41kg total extract. The extract was extracted with n-butanol to obtain 3.1 L of n-butanol extract, and n-butanol was recovered under reduced pressure to obtain n-butanol extract (dry weight 269 g).

[0017] Mix 269g of n-butanol extract with 300g of silica gel (200-300 mesh), ventilate and dry, grind into a powder, put it into a normal phase silica gel column (column volume: 8000mL) by wet column method, and choose to use CHCl 3 -MeOH system (CHCl 3 : MeOH=10:1, 10:2, 10:3, 0:10 / V:V) sequential gradient elution, the eluent volume of each polar segment was 32000mL, and a total of 75 fractions we...

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Abstract

The invention discloses a caffeic acid derivate (Marilide A) which is extracted and separated from mangrove avicennia marina fruit and belongs to a natural active component. The caffeic acid derivate is easily soluble in methanol and ethanol, and has favorable alcoholphilicity. The antioxidation-activity cytological quantitative analysis test detects that the antioxidation activity EC50 value of the caffeic acid derivate is much less than that of the positive control quercetin, and the caffeic acid derivate has favorable antioxidation activity and can be independently or combinedly used as a medicinal or non-medicinal antioxidant or the like.

Description

technical field [0001] The invention belongs to the technical field of antioxidants, in particular to a caffeic acid derivative compound and its preparation method and application. Background technique [0002] Free radicals with strong chemical reactivity and short lifespan will be produced in the process of human metabolism. Under normal physiological conditions, the free radical scavenging system (also known as the antioxidant system) in the human body can effectively scavenge excessive free radicals and protect cells and tissues from the damaging attacks of free radicals. Under pathological conditions, the body's free radical production and scavenging system is out of balance, resulting in excess free radicals. Clinical trials and epidemiology have shown that excess free radicals can induce oxidative stress, which can cause oxidative damage to biological macromolecules (such as DNA, lipids, and proteins), leading to chronic diseases such as cancer, aging, cardiovascular...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D313/18A61K31/365A61P39/06C09K15/08
CPCC07D313/18C09K15/08
Inventor 颜栋美余炼覃媚
Owner GUANGXI UNIV
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