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Method for synthesizing fluorescent magnetic resonance imaging contrast agent

A technology of magnetic resonance imaging and synthesis method, which is applied in the direction of pharmaceutical formulations, preparations for in vivo tests, etc., and can solve problems such as strong reactivity, low magnetic permeability, and easy loss of magnetism

Inactive Publication Date: 2014-10-08
JILIN INST OF CHEM TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, they are more or less unpackaged, highly reactive, easy to adsorb other impurity ions, low magnetic permeability, unstable chemical properties in blood, and easy to lose magnetism.

Method used

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  • Method for synthesizing fluorescent magnetic resonance imaging contrast agent

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Embodiment Construction

[0011] 1. Synthesis of a quantum dot

[0012] First, in 2 mL of aqueous solution, an appropriate amount of sodium borohydride and 2.9 mg of tellurium powder were mixed and reacted to prepare sodium tellurium hydride solution 1; 100 mL of water was added to a three-necked flask, and cadmium chloride was added to adjust the pH to 11.4. In 100 μL In the presence of a mercaptopropionic acid stabilizer, add freshly prepared Solution 1 to this solution and heat. At room temperature, using rhodamine 6G as a control, the quantum efficiency of the synthesized quantum dots was measured to be about 25%.

[0013] 2. Synthesis of ferric oxide

[0014] 1) Weigh a certain amount of ammonia water into a 100 ml three-necked flask, and keep it in a small flow of nitrogen atmosphere for 15 minutes;

[0015] 2) Weigh a certain amount of ferric chloride and ferrous chloride into a small beaker, add water and stir until completely dissolved, add dropwise to the above ammonia water, stir vigorousl...

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Abstract

The invention designs a method for synthesizing a magnetic resonance imaging contrast agent by applying synthesis of polylactic acid, a CdTe quantum dot and ferroferric oxide. The method comprises the following step: on the basis of selecting ferroferric oxide as a magnetic molecule and a near infrared CdTe quantum dot as an optical imaging molecule, compounding the ferroferric oxide and the near infrared CdTe quantum dot in a polylactic acid microsphere by virtue of a self-assembly mode to prepare the multifunctional magnetic resonance imaging contrast agent with magnetic resonance imaging, fluorescent imaging and biological targeting functions.

Description

technical field [0001] The present invention proposes to design and develop a synthesis method of a novel magnetic resonance imaging contrast agent that has the functions of magnetic resonance imaging, fluorescence imaging and biological targeting. Background technique [0002] In 1957, magnetic particles began to be used in medical applications. Magnetic particles were injected into the lesion of tumor patients, and then an AC magnetic field was applied externally to induce heating to increase the local temperature of the tumor lesion, which could directly kill cancer cells. . Since the 1990s, a new therapy combining nanotechnology and hyperthermia—Magnetic Fluid Hyperthermia (MFH)—has been adopted. Magnetic fluid thermotherapy refers to using an external magnetic field to guide the magnetic fluid to the target area of ​​the tumor lesion, and then applying a high-frequency alternating magnetic field on the target area to generate a hysteresis thermal effect, resulting in a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/12
Inventor 张建坡李岩郝希云
Owner JILIN INST OF CHEM TECH
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