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Hilicidum injection for preventing and treating ischemic cardiovascular and cerebrovascular diseases as well as preparation method and application thereof

A technology for cardiovascular and cerebrovascular diseases and glycoside injections, which is applied in the field of medicine and can solve problems such as no research reports on cardiovascular and cerebrovascular diseases

Active Publication Date: 2014-10-01
KPC PHARM INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The clinical application of tofu glucoside in the prevention and treatment of ischemic cardiovascular and cerebrovascular diseases has not yet been reported

Method used

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  • Hilicidum injection for preventing and treating ischemic cardiovascular and cerebrovascular diseases as well as preparation method and application thereof
  • Hilicidum injection for preventing and treating ischemic cardiovascular and cerebrovascular diseases as well as preparation method and application thereof
  • Hilicidum injection for preventing and treating ischemic cardiovascular and cerebrovascular diseases as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Tofu glucoside injection

[0030] Prescription composition:

[0031] Tofu fruit glycosides 500g

[0032] Propylene glycol 1000g

[0033] Sodium chloride 900g

[0034] Preparation method: Take 10L of water for injection, add it to 45°C, add propylene glycol, stir to make it dissolve completely, then add the prescribed amount of tofu fruit glycosides, stir until it becomes clear and transparent, then add sodium chloride and 50g of activated carbon, at 60°C Stir under the same conditions for 20 minutes, then filter to remove carbon, add water for injection to 50L, then filter through a 0.22μm filter membrane, potting, steam sterilization at 121°C for 12 minutes, and the product is obtained. The specification of the obtained tofu glucoside injection is: 50ml: 0.5g.

[0035]

Embodiment 2

[0037] Tofu glucoside injection

[0038] Prescription composition:

[0039] Tofu fruit glycosides 20g

[0040] Ethanol 40ml

[0041] Sodium chloride 18g

[0042]Preparation method: Take 1L of water for injection, add it to 45°C, add ethanol, stir to make it dissolve completely, then add the specified amount of tofu fruit glycosides, stir until it becomes clear and transparent, then add sodium chloride and 50g of activated carbon, and heat at 60°C Stir under the same conditions for 20 minutes, then filter to remove carbon, add water for injection to 2L, then filter through a 0.22μm filter membrane, potting, steam sterilization at 121°C for 12 minutes, and the product is obtained. The specifications of the obtained tofu glucoside injection are: 2ml: 20mg.

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Abstract

The invention discloses a hilicidum injection for preventing and treating ischemic cardiovascular and cerebrovascular diseases as well as a preparation method and application thereof. The injection comprises 20-2000 parts of hilicidum, 40-4000 parts of cosolvent, 18-900 parts of sodium chloride and the balance of water by weight. The preparation method is characterized by comprising the following steps: taking water for injection, adding the cosolvent, stirring the cosolvent to completely dissolve the cosolvent, then adding hilicidum, stirring the solution until the solution is clear and transparent, then adding sodium chloride and activated carbon, stirring the solution, filtering the solution to remove carbon, adding the water for injection and carrying out filtration, filing and sterilization, thus obtaining the hilicidum injection. The hilicidum injection is applied to medicines for preventing and / or treating ischemic cardiovascular and cerebrovascular diseases. The hilicidum in the hilicidum injection can obviously reduce the volume of global ischemic and focal ischemic cerebral infarction, is used for preventing and treating ischemic cerebral infarction, can obviously lower a J point of a limb lead electrocardiogram of rats with acute myocardial ischemia and reduce the ischemic area and can be used for preventing and treating ischemic myocardial infarction.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a bean curd glucoside injection for preventing and treating ischemic cardiovascular and cerebrovascular diseases, a preparation method and application thereof. Background technique [0002] Ischemic cardiovascular and cerebrovascular diseases are one of the most important diseases leading to death and disability in modern society. In particular, China has become a high-incidence area for ischemic cardiovascular and cerebrovascular diseases. This disease is a series of heart or brain tissue damage caused by ischemia and hypoxia in the corresponding area of ​​the heart or brain tissue caused by heart and / or brain blood supply disorders. Diseases such as abnormal biochemical metabolism, loss of physiological functions, and softening and changing of patient morphology are diseases that damage the heart and brain tissue at multiple levels and in many ways. Among them, ce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/7034A61P9/10
Inventor 张伟杨兆祥刘一丹
Owner KPC PHARM INC
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