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Ceftiofur hydrochloride cream and preparation method thereof

A technology for ceftiofur hydrochloride and thiifur cream is applied in the directions of ointment delivery, pharmaceutical formulation, aerosol delivery and the like, and achieves the effects of easy industrialization, simple preparation process and low production cost

Active Publication Date: 2014-09-17
LINYI UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The introduction of ceftiofur hydrochloride and the research on its preparations in my country are relatively late, and the production and sales licenses approved by the Ministry of Agriculture are limited to ceftiofur hydrochloride raw materials and their injections

Method used

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  • Ceftiofur hydrochloride cream and preparation method thereof
  • Ceftiofur hydrochloride cream and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1   preparation example 1

[0034] Prednisolone Hydroxide Acetate 0.1 g

[0035] Vitamin E 0.1g

[0036] Glyceryl monostearate 13g

[0037] White Vaseline 5g

[0038] Lanolin 7g

[0039] Liquid paraffin 50g

[0040] Span 80 3g

[0041] Polysorbate 80 2.2g

[0042] Ethylparaben 0.1g

[0043] Purified water 22g

[0044] The preparation method of ceftiofur hydrochloride cream of the present invention is as follows:

[0045] (1) Micronize ceftiofur hydrochloride and pass through a 100-400 mesh sieve;

[0046] (2) Weigh the prescribed amount of glyceryl monostearate, white petrolatum, lanolin, liquid paraffin, Span 80, and vitamin E in a beaker, heat it in a water bath to 80°C to melt it, and stir evenly with a magnetic force at a speed of 900r / min, is the oil phase;

[0047] (3) Weigh the prescription amount of polysorbate 80, ethylparaben and purified water in a beaker, heat it in a water bath to 80°C, stir evenly with a magnetic force at a speed of 700r / min, and form the water phase;

[0048] (...

Embodiment 3   preparation example 3

[0072] Prednisolone Hydroxide Acetate 0.04g

[0073] Vitamin E 0.05g

[0074] Glyceryl monostearate 10g

[0075] White Vaseline 10g

[0076] Lanolin 3g

[0077] Liquid paraffin 53.01g

[0078] Span 80 5g

[0079] Polysorbate 80 0.8g

[0080] Ethylparaben 0.1g

[0081]Purified water 15g

[0082] The preparation method of ceftiofur hydrochloride cream of the present invention is as follows:

[0083] (1) Micronize ceftiofur hydrochloride and pass through a 100-400 mesh sieve;

[0084] (2) Weigh the prescribed amount of glyceryl monostearate, white petrolatum, lanolin, liquid paraffin, Span 80, and vitamin E in a beaker, heat it in a water bath to 80°C to melt it, and stir evenly with a magnetic force at a speed of 500r / min, for the oil phase;

[0085] (3) Weigh the prescription amount of polysorbate 80, ethylparaben and purified water in a beaker, heat it in a water bath to 80°C, stir evenly with a magnetic force at a speed of 700r / min, and form the water phase;

[00...

Embodiment 4   preparation example 4

[0091] Prednisolone Acetate 0.1g

[0092] Vitamin E 0.2g

[0093] Glyceryl monostearate 12g

[0094] White Vaseline 8g

[0095] Lanolin 8g

[0096] Liquid paraffin 10g

[0097] Span 80 3g

[0098] Polysorbate 80 2g

[0099] Ethylparaben 0.08g

[0100] Purified water 55.12g

[0101] The preparation method of ceftiofur hydrochloride cream of the present invention is as follows:

[0102] (1) Micronize ceftiofur hydrochloride and pass through a 100-400 mesh sieve;

[0103] (2) Weigh the prescribed amount of glyceryl monostearate, white petrolatum, lanolin, liquid paraffin, Span 80, and vitamin E in a beaker, heat it in a water bath to 80°C to melt it, and stir evenly with a magnetic force at a speed of 800r / min, for the oil phase;

[0104] (3) Weigh the prescription amount of polysorbate 80, ethylparaben and purified water into a beaker, heat in a water bath to 80°C, stir evenly with a magnetic force at a speed of 600r / min, and form the water phase;

[0105] (4) Slowly...

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PUM

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Abstract

The invention relates to ceftiofur hydrochloride cream and a preparation method thereof. The ceftiofur hydrochloride cream comprises ceftiofur hydrochloride, prednisolone acetate, vitamin E, monoglyceride stearate, albolene, lanolin, liquid paraffin, span 80, polysorbate 80, ethylparaben and purified water. The preparation method comprises the following steps of preparing an oil phase and a water phase, adding ceftiofur hydrochloride and prednisolone acetate into the oil phase and the water phase, and carrying out mixing to obtain a uniform mixture. The ceftiofur hydrochloride cream can be used for treating cow mastitis.

Description

technical field [0001] The invention relates to a ceftiofur hydrochloride cream and a preparation method thereof. Background technique [0002] Cow mastitis is a disease of udder tissue and nipple inflammation caused by pathogenic microorganisms and other factors. At present, there are about 230 million dairy cows in the world, about 1 / 3 of which suffer from various types of mastitis, and the annual loss due to mastitis is as high as 300 billion yuan. In my country, the positive rate of cow mastitis is as high as 50% to 70%, and the economic loss is about 135 million yuan. Therefore, mastitis has become the most common in veterinary clinics, and it is also the most harmful disease to dairy cow production. At present, antibiotic injection is still the most commonly used method to treat dairy cow mastitis in China, but there are problems such as large dose of antibiotics, serious bacterial resistance, and poor clinical treatment effect. [0003] Ceftiofur hydrochloride is a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/573A61K9/06A61P31/04A61P15/14A61K31/546A61K31/355
Inventor 李振
Owner LINYI UNIVERSITY
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