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Method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template

An octreotide acetate, coral-like technology is applied in the field of preparation of nanomaterials, can solve the problems of inability to obtain particle size, single component, good dispersibility, etc., and achieves the effects of low preparation cost, simple preparation process and good dispersibility

Inactive Publication Date: 2014-09-03
YANSHAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The object of the present invention is to provide a method for preparing coral-shaped nano-cobalt using octreotide acetate as a template with low preparation cost, no pollution, simple process and controllability, so as to solve the problem that the liquid phase reduction method cannot obtain small particle size, good dispersibility and Conundrums of Single Cobalt Nanoparticles

Method used

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  • Method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template
  • Method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template
  • Method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template

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Embodiment 1

[0019] Take 0.4 mg of octreotide acetate (produced by Jill Biochemical Shanghai Co., Ltd.), and dissolve it in 1 mL of hydrochloric acid solution of pH 2, so that the pH of the octreotide acetate solution is 2; Reagent Co., Ltd.); put the above-prepared solution into a water bath constant temperature oscillator, incubate at 100rpm., 13°C for 26h, then add 50mM reducing agent sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd. ) 80 μL for reduction, making it from light pink to deep black, namely to obtain octreotide acetate-nano-cobalt particles.

[0020] Morphological characterization of coral-like cobalt nanoparticles using transmission electron microscopy, such as figure 1 As shown, the diameter of the coral-like nano-cobalt particles is about 55nm, the shape is regular, and the distribution is uniform.

Embodiment 2

[0022] Take 0.6 mg of octreotide acetate (produced by Jill Biochemical Shanghai Co., Ltd.), and dissolve it in 1 mL of pH 2.5 hydrochloric acid solution, so that the pH of the octreotide acetate solution is 2.5; take 200 μL of the above-mentioned octreotide acetate solution, add 200 μL of 6 mM cobalt chloride solution ( Shanghai West Asia Reagent Co., Ltd.); put the above-mentioned prepared solution into a water-bath constant temperature oscillator, and after incubating at 150rpm., 20°C for 24h, add 40mM reducing agent sodium borohydride (Beijing Zhongsheng Huateng Technology Co., Ltd. Produced by the company) 90 μL was reduced to make it change from light pink to deep black, and octreotide acetate-nano-cobalt particles were obtained.

[0023] Morphological characterization of coral-like cobalt nanoparticles using transmission electron microscopy, such as figure 2 As shown, the diameter of the coral-shaped cobalt nanoparticles is about 60-70nm, the shape is regular, and the d...

Embodiment 3

[0026] Take 0.8 mg of octreotide acetate (produced by Jill Biochemical Shanghai Co., Ltd.), and dissolve it in 1 mL of hydrochloric acid solution of pH 3, so that the pH of the octreotide acetate solution is 3; Reagent Co., Ltd.); put the above prepared solution into a water bath constant temperature oscillator, incubate at 200rpm., 25°C for 20h, then add 32mM reducing agent sodium borohydride (produced by Beijing Zhongsheng Huateng Technology Co., Ltd. ) 100 μL for reduction, making it change from light pink to dark black to obtain octreotide acetate-nanocobalt particles.

[0027] Morphological characterization of coral-like cobalt nanoparticles using transmission electron microscopy, such as Figure 4 As shown, the coral-shaped cobalt nano particles have a diameter of about 40-50 nm, regular shape and uniform distribution.

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Abstract

A method for manufacturing coralline nanometer cobalt by using octreotide acetate as a template mainly comprises the steps that the octreotide acetate is dissolved through pH2-3 hydrochloric acid, the octreotide acetate is regulated into an acid solution, a cobalt chloride solution is added in the regulated solution with the mole ratio of 1:10-20, the solution is then put in a water bath constant temperature oscillator, and hatching is carried out for 20-26 hours under the temperature of 13-25 DEG C at 100-200 rpm.; then, the reducing agent sodium borohydride is added in the hatched solution at a time so that the hatched solution is changed into dark black from light pink, and the black product is octreotide acetate-nanometer cobalt particles, wherein the mole ratio of the reducing agent sodium borohydride and the cobalt chloride is 1:25-35. The method for manufacturing the coralline nanometer cobalt by using the octreotide acetate as the template has the advantages that the manufacturing technology is simple, conditions are mild, the coralline nanometer cobalt is cheap and easy to obtain, the reaction is easy to control, and the productivity is high.

Description

technical field [0001] The invention belongs to the technical field of nanometer metal materials, and in particular relates to a preparation method of nanometer materials. Background technique [0002] Nano-cobalt particles have many uses as high-performance magnetic recording materials, magnetic fluids, wave-absorbing materials, and activated sintering additives in the electronics industry, magnetism, hard alloys, surface spraying, chemical catalysis and other industrial fields. [0003] The preparation methods of nano-cobalt particles include thermal decomposition method, precipitation-thermal decomposition method, hydrogen reduction method, microemulsion method and so on. Some of the above-mentioned preparation methods have high technical requirements, expensive equipment, some complicated processes, and greater environmental pollution, and some require longer reaction time, higher temperature and pressure, and special reversing devices, resulting in higher production cos...

Claims

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Application Information

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IPC IPC(8): B22F9/24B82Y40/00B82Y30/00
Inventor 高大威赵晓宁高发明周景薛伟利王梓骆丽垚刘艳平
Owner YANSHAN UNIV
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