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Pharmaceutical preparation used for treating cold urticaria

A pharmaceutical preparation and urticaria technology, applied in the field of pharmaceutical preparations for the treatment of cold urticaria, can solve the problems of unsatisfactory curative effect, uncontrollable recurrence, difficult treatment, etc., achieve remarkable therapeutic effect, low recurrence rate, and reduce pain Effect

Inactive Publication Date: 2014-08-20
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] At present, for the treatment of cold urticaria, Western medicine recommends cyproheptadine or milistine, but the curative effect is often unsatisfactory. Adrenal corticosteroids and immunosuppressants have certain effects, but the side effects are large, and the recurrence cannot be controlled. , and will bring difficulties to the treatment of the attack

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] The present invention also provides a preparation method of the above-mentioned pharmaceutical preparation when the prepared dosage form is a granule, specifically,

[0030] The first step is to combine ephedra, geese not eating grass, schisandra, Poria cocos, clematis, houttuynia cordata, knotweed, dandelion, geranium, sealwort, shouwu vine, dendrobium, dodder, gardenia, burdock, spiced herbs, Yuanbaocao, rhubarb, mulberry and jiulongteng were pulverized respectively, sent to a blender and mixed evenly to obtain a mixture, and the alcohol concentration was 95% ethanol for reflux extraction twice, and for the first time, 8 times the mass of the mixture was added Ethanol, reflux for 2 hours; add ethanol in an amount 7 times the mass of the mixture for the second time, reflux for 1 hour, and filter; combine the filtrates twice, concentrate under reduced pressure to a clear paste with a temperature of 60°C and a relative density of 1.30 to 1.32 for later use ; Simultaneous...

Embodiment 1

[0068] Embodiment 1 Granule 1

[0069] 40g ephedra, 25g goose grazing grass, 40g schisandra, 25g tuckahoe, 15g clematis, 25g houttuynia cordata, 40g knotweed, 35g dandelion, 20g geranium yellow, 40g sealwort, 25g shouwu vine, 30g dendrobium, 25g dodder, 30g gardenia, 20g arctium, 15g five-spice grass, 25g rhubarb, 15g rhubarb, 30g mulberry and 15g vine, pulverize them respectively, put them into a blender and mix evenly to obtain a mixture, add alcohol concentration to 95% ethanol for reflux extraction 2 times, add ethanol in an amount 8 times the mass of the mixture for the first time, and reflux for 2 hours; add ethanol in an amount 7 times the mass of the mixture for the second time, reflux for 1 hour, and filter; combine the 2 filtrates and depressurize Concentrate to a clear paste with a temperature of 60°C and a relative density of 1.30 for later use; volatilize ethanol at the same time, and keep the medicinal residues for use. The medicinal residues obtained above, 30g ...

Embodiment 2

[0070] Embodiment 2 Granules 2

[0071] 45g ephedra, 30g goose grazing grass, 45g schisandra, 30g tuckahoe, 20g clematis, 30g houttuynia, 45g knotweed, 40g dandelion, 20g geranium, 40g sealwort, 25g shouwu vine, 30g dendrobium, 25g dodder, 30g gardenia, 20g arctium, 15g five-spice grass, 25g rhubarb, 15g rhubarb, 30g mulberry and 15g vine, pulverize them respectively, put them into a blender and mix evenly to obtain a mixture, add alcohol concentration to 95% ethanol for reflux extraction 2 times, add ethanol in an amount 8 times the mass of the mixture for the first time, and reflux for 2 hours; add ethanol in an amount 7 times the mass of the mixture for the second time, reflux for 1 hour, and filter; combine the 2 filtrates and depressurize Concentrate to a clear paste with a temperature of 60°C and a relative density of 1.30 for later use; volatilize ethanol at the same time, and keep the medicinal residues for use. The medicinal residues obtained above, 35g of notopterygi...

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Abstract

The invention provides a pharmaceutical preparation used for treating cold urticaria. The pharmaceutical preparation is prepared from the following crude drugs: ephedra, centipeda minima, notopterygium root, paniculate swallowwort root, schisandra chinensis, rhizoma corydalis, logwood, tuckahoe, radix clematidis, houttuynia cordata, polygonum cuspidatum, dandelion, schizonepeta, root of red-rooted salvia, tabasheer, sealwort, vine of multiflower knotweed, dendrobium nobile, seed of Chinese dodder, jasmine, burdock, belvedere fruit, morinda officinalis, mosla scabra, hypericum sampsonii hance, mangnolia officinalis, rhaponticum, mistletoe and bauhinia championii. The pharmaceutical preparation disclosed by the invention is remarkable in treatment effect, less in side effect and low in recurrence rate, and has great significance in reducing pains of a patient with urticaria and preventing urticaria.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine, in particular to a pharmaceutical preparation for treating cold urticaria. Background technique [0002] Urticaria is a localized edema reaction caused by dilation and increased permeability of small blood vessels in the skin and mucosa. The disease is characterized by sudden local or whole body wheals of different sizes, protruding surface, severe spasm and itching, no fixed place, rising and retreating suddenly, coming and going quickly, and leaving no trace after subsiding. In traditional Chinese medicine, it is called "addiction rash", "rubella" and so on. Common pathogenic factors include food, drugs, infection, physical factors, chemical factors, visceral and systemic diseases, etc. [0003] Cold urticaria is a special type of urticaria. Due to the stimulation of cold air, cold water or cold objects, spasmodic wheals, edema, and erythema appear on exposed or touched p...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/16A61K9/20A61P17/00
Inventor 翁婉丹江峰靳一鸣徐雷张杰古洪亮
Owner NINGBO UNIV
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