Corneal injury scar-free repairing device and application thereof

A corneal injury and scar technology, applied in the field of scarless corneal injury repair device, can solve the problems that drug treatment cannot achieve the ideal therapeutic effect, infection and corneal perforation, lack of treatment methods for corneal disease, etc., to protect the wound site, good moisture and anti-precipitation properties, the effect of preventing corneal scar formation

Inactive Publication Date: 2014-08-20
周辉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But there are also its insurmountable shortcomings: 1) the amniotic membrane transplanted will dissolve and absorb within a few days or weeks after the operation, and sometimes requires multiple operations, which brings great pain to the patient; Only a few well-known ophthalmologists can implement it in a well-equipped eye hospital; 3) The suturing process of amniotic membrane will inevitably cause certain ocular tissue damage; 4) There are infection and corneal per

Method used

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  • Corneal injury scar-free repairing device and application thereof

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Embodiment 1

[0034] 1. Pretreatment of Amnion

[0035] There are many methods for amniotic membrane pretreatment. This embodiment adopts: the placenta obtained by selective cesarean section is immediately treated with a physiological solution containing 50 mg / L penicillin, 50 mg / L streptomycin and 215 mg / L amphotericin B under sterile conditions. The blood was washed away with saline, and then the amniotic membrane was bluntly separated from the chorion of the placenta, and spread flat on the paper sheet of surgical tissue paper (the epithelial side was facing upward). -80 ℃ 1:1 glycerol BDMEM preservation. Prenatal testing of placenta donor hepatitis B surface antigen, AIDS antigen, chlamydia, syphilis, cytomegalovirus, etc. were negative, and no history of other malignant tumors and infectious diseases.

[0036] 2. Fabrication of contact lenses

[0037] A special biological material is used to precisely process the contact lens with a CNC lathe, and at the same time, a number of micro h...

Embodiment 2

[0044] Corneal (conjunctiva) injury scarless repair devices include: amniotic membrane pretreatment methods, structures of various biological or synthetic devices including contact lenses, amnion and various biological or synthetic devices including contact lenses, etc. The bonding method of the synthetic attachment device, the preparation method of oxygen permeation and oxygen permeable hole of the corneal (conjunctival) membrane injury repair device without scar, the use method of amniotic membrane eye drops / amniotic membrane storage solution, and the medicine for treating cornea and conjunctival injury are fixed on the method on the amniotic membrane. Further: Extract amniotic membrane from human or mammalian (such as pig, horse or cow, etc.) amniotic tissue and placental tissue and biologically recombine the amniotic membrane, and combine the amniotic membrane with various biological or synthetic devices including contact lenses Through the new carrier controlled release t...

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Abstract

The invention relates to a corneal injury scar-free repairing device and application thereof. Specially-prepared amnion elements are settled or bonded in or on the surfaces of various biological or synthetic attaching devices such as the invisible contact lens through the novel carrier controlled release technology and the biological tissue engineering technology so as to form the corneal or conjunctiva injury scar-free repairing device. At the early stage of the corneal or conjunctiva injury, the affected corneal tissue or the affected conjunctiva tissue is covered with the amnion elements of the corneal or conjunctiva injury scar-free repairing device, the amnion elements, such as the necessary cell growth factors, the tissue repair factors and protease inhibitors, of the corneal or conjunctiva injury scar-free repairing device are diffused to the affected corneal tissue or the affected conjunctiva tissue due to the special superfine structure of an amnion basilar membrane and the stem cell characteristic of amniotic epithelial cells, and therefore growth of epithelial cells of the corneal or the conjunctiva is promoted, the affected corneal tissue or the affected conjunctiva tissue is stimulated, regulated and controlled to heal orderly, and less scars are formed on the affected corneal tissue or the affected conjunctiva tissue.

Description

technical field [0001] The present invention utilizes new carrier controlled release technology and tissue engineering technology to develop a new type of biomedical product and new ophthalmic treatment material, especially relates to the field of scarless repair of corneal injury, and is useful for the existing clinical method of preventing and treating scar formation of corneal trauma There are major improvements and innovations. In particular, it relates to a scarless repair device for corneal damage and its application. Background technique [0002] According to the latest statistics released by the World Health Organization (WHO), 7 million people around the world become blind every year, and there are currently nearly 45 million blind people in the world. China is the country with the largest number of blind people in the world. There are about 12 million visually disabled people, of whom nearly 7 million are blind, accounting for about 1 / 6 of the total number of blin...

Claims

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Application Information

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IPC IPC(8): A61F9/00A61M35/00
Inventor 周辉
Owner 周辉
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