Corneal injury scar-free repairing device and application thereof

Abstract

The invention relates to a corneal injury scar-free repairing device and application thereof. Specially-prepared amnion elements are settled or bonded in or on the surfaces of various biological or synthetic attaching devices such as the invisible contact lens through the novel carrier controlled release technology and the biological tissue engineering technology so as to form the corneal or conjunctiva injury scar-free repairing device. At the early stage of the corneal or conjunctiva injury, the affected corneal tissue or the affected conjunctiva tissue is covered with the amnion elements of the corneal or conjunctiva injury scar-free repairing device, the amnion elements, such as the necessary cell growth factors, the tissue repair factors and protease inhibitors, of the corneal or conjunctiva injury scar-free repairing device are diffused to the affected corneal tissue or the affected conjunctiva tissue due to the special superfine structure of an amnion basilar membrane and the stem cell characteristic of amniotic epithelial cells, and therefore growth of epithelial cells of the corneal or the conjunctiva is promoted, the affected corneal tissue or the affected conjunctiva tissue is stimulated, regulated and controlled to heal orderly, and less scars are formed on the affected corneal tissue or the affected conjunctiva tissue.

Description

technical field [0001] The present invention utilizes new carrier controlled release technology and tissue engineering technology to develop a new type of biomedical product and new ophthalmic treatment material, especially relates to the field of scarless repair of corneal injury, and is useful for the existing clinical method of preventing and treating scar formation of corneal trauma There are major improvements and innovations. In particular, it relates to a scarless repair device for corneal damage and its application. Background technique [0002] According to the latest statistics released by the World Health Organization (WHO), 7 million people around the world become blind every year, and there are currently nearly 45 million blind people in the world. China is the country with the largest number of blind people in the world. There are about 12 million visually disabled people, of whom nearly 7 million are blind, accounting for about 1 / 6 of the total number of blin...

AI Technical Summary

Problems solved by technology

But there are also its insurmountable shortcomings: 1) the amniotic membrane transplanted will dissolve and absorb within a few days or weeks after the operation, and sometimes requires multiple operations, which brings great pain to the patient; Only a few well-known ophthalmologists can implement it in a well-equipped eye hospital; 3) The suturing process of amniotic membrane will inevitably cause certain ocular tissue damage; 4) There are infection and corneal perforation in the acute stage of corneal trauma in amniotic membrane transplantation 5) AMT has great limitations in the treatment of severe eye diseases and corneal trauma

[0011] In view of the current lack of treatment methods for corneal diseases, as well as the corneal haze / scar caused by the existing laser ablation surgery of corneal tissue, and the inability of drug therapy to achieve the desired therapeutic effect, an effective treatment method is urgently needed

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