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Medicinal substance with dementia resistance, as well as preparation method and application thereof

A drug and substance technology, applied in the field of traditional Chinese medicine composition with anti-dementia effect and its preparation field, can solve the problems such as no anti-dementia drug substance combination, no dementia disease research report, etc.

Active Publication Date: 2014-08-13
石任兵 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no related reports on the purification and preparation of anti-dementia drug substance combinations from Kaixin Powder, and there are no related research reports on the composition in the treatment of dementia.

Method used

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  • Medicinal substance with dementia resistance, as well as preparation method and application thereof
  • Medicinal substance with dementia resistance, as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Embodiment 1: Capsules

[0055] Poria cocos 400g Ginseng 200g

[0056] Polygala 200g Shichangpu 200g

[0057] Take 1 kg of raw material medicine decoction pieces according to the above ratio, reflux extraction with 50% ethanol 10L for 3 times, extract for 1.5 hours each time, reclaim the solvent under reduced pressure, and obtain the extract; According to the meter, wherein the concentration of terpenoids is 1.755mg / ml, and the concentration of phenols is 1.190mg / ml), the sample solution passes through the 4LDM130 type macroporous adsorption resin, the adsorption flow rate is 3BV / h, and the ratio of diameter to height of the resin column is 1: 8.7, Elute 2 times the resin volume with water for impurity removal, the impurity removal flow rate is 3BV / h, 30% ethanol elutes 5 times the resin volume, the elution flow rate is 3BV / h, collect the 30% ethanol eluate, recover the solvent, and depressurize Dry to obtain phenolic active components, elute with 90% ethanol for 5 time...

Embodiment 2

[0076] Embodiment 2: tablet

[0077] Poria cocos 350g Ginseng 280g

[0078] Polygala 260g Shichangpu 180g

[0079] Take 1 kg of raw material medicine decoction pieces according to the above ratio, reflux extraction with 50% ethanol 10L for 3 times, extract for 1.5 hours each time, reclaim the solvent under reduced pressure, and obtain the extract; According to the meter, wherein the concentration of terpenoids is 1.755mg / ml, and the concentration of phenols is 1.190mg / ml), the sample solution passes through the 4LDM130 type macroporous adsorption resin, the adsorption flow rate is 3BV / h, and the ratio of diameter to height of the resin column is 1: 8.7, Elute 2 times the resin volume with water for impurity removal, the impurity removal flow rate is 3BV / h, 30% ethanol elutes 5 times the resin volume, the elution flow rate is 3BV / h, collect the 30% ethanol eluate, recover the solvent, and depressurize Dry to obtain phenolic active components, elute with 90% ethanol for 5 time...

Embodiment 3

[0098] Embodiment 3: pill

[0099] Poria cocos 560g Ginseng 160g

[0100] Polygala 180g Shichangpu 270g

[0101] Take 1 kg of raw material medicine decoction pieces according to the above ratio, reflux extraction with 50% ethanol 10L for 3 times, extract for 1.5 hours each time, reclaim the solvent under reduced pressure, and obtain the extract; According to the meter, wherein the concentration of terpenoids is 1.755mg / ml, and the concentration of phenols is 1.190mg / ml), the sample solution passes through the 4LDM130 type macroporous adsorption resin, the adsorption flow rate is 3BV / h, and the ratio of diameter to height of the resin column is 1: 8.7, Elute 2 times the resin volume with water for impurity removal, the impurity removal flow rate is 3BV / h, 30% ethanol elutes 5 times the resin volume, the elution flow rate is 3BV / h, collect the 30% ethanol eluate, recover the solvent, and depressurize Dry to obtain phenolic active components, elute with 90% ethanol for 5 times ...

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Abstract

The invention belongs to the field of medicine research and development, relates to a medicinal substance, and particularly relates to a medicinal substance with dementia resistance and a preparation method thereof. The medicinal substance is obtained by performing ethanol extraction and macro-porous adsorption resin purification on Kaixin powder, and is enriched with phenolic acid ingredients and terpene ingredients in the Kaixin powder; meanwhile, mouse dysmnesia tests prove that the medicinal substance can be used for strengthening the capability of passive escape electrical stimulation of mice, reducing error times and reducing the activity of acetylcholin esterase in the cerebral cortex of a mouse, so that the aims of improving memory and resisting dementia can be achieved.

Description

technical field [0001] The invention relates to a drug substance, in particular to a traditional Chinese medicine composition with anti-dementia effect and a preparation method thereof. Background technique [0002] Dementia is a persistent mental disorder, the etiology is very complex, both genetic factors, and acquired environmental influence and induction, can cause dementia as many as one hundred kinds of diseases. Currently listed drugs can only play a role in improving symptoms of senile dementia. Therefore, so far, there is still a lack of effective treatments to control the disease process. With its multi-component and multi-target advantages, traditional Chinese medicine has more development prospects. [0003] Kaixin San first appeared in "Prescriptions for Emergencies and Thousands of Gold". It consists of four parts each of ginseng and polygala, two liang of Poria cocos, and one liang of calamus calamus. It is a representative prescription for nourishing qi, n...

Claims

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Application Information

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IPC IPC(8): A61K36/888A61P25/28A61P31/04A61P29/00A61P11/14A61P11/10A23L1/29A23L2/38A23L33/00
Inventor 石任兵王永炎张璐李焕娟彭平姜艳艳朱乃亮
Owner 石任兵
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