Method for constructing regenerated nerve vascularized bones, cartilages, joints or body surface organs

A neurovascular and organ technology, applied in the fields of medicine and bioengineering, can solve problems such as fusion growth, exposure, and inability to self-generate

Inactive Publication Date: 2014-07-30
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, these methods still do not completely avoid the involvement of in vitro culture process, exogenous growth factors, exogenous genes, etc.
Moreover, after implantation of regenerative tissue, exogenous cells, materials, growth factors, etc. can easily cause complications such as rejection, infection, cyst formation, non-degradable materials, and exposure. This safety problem has not been completely resolved, which seriously restricts The clinical application of the above-mentioned

Method used

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  • Method for constructing regenerated nerve vascularized bones, cartilages, joints or body surface organs
  • Method for constructing regenerated nerve vascularized bones, cartilages, joints or body surface organs
  • Method for constructing regenerated nerve vascularized bones, cartilages, joints or body surface organs

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Example 1 Prefabrication of internal ear-shaped cartilage and reconstruction of external ear

[0059] The specific method is realized through the following technical solutions:

[0060] (1) According to the tissue\organ defect, the use of (CAD / CAM) technology to accurately and personalized three-dimensional printing needs to construct the tissue shape

[0061] In order to perform ear reconstruction for patients with personalized microtia, head CT scan was performed before surgery. The CT data is output in DICOM (Digital Imaging and Communications in Medicine) format, and 3D modeling processing is performed through Medgraphics software and Magic.RP (Magic Rapid Prototyping) software to obtain a 3D model of the ear ( figure 1 ). Using mirroring technology, according to the shape of the normal side ear, perform 3D simulation and reconstruction processing on the affected side ear to obtain the 3D model of the affected side normal ear, and then through the stereolithography (Ster...

Embodiment 2

[0074] Example 2 In vivo bone prefabrication and reconstruction of skull defect

[0075] The specific method is realized through the following technical solutions:

[0076] (1) According to the skull defect, use (CAD / CAM) technology to accurately and personalized three-dimensional printing of the tissue shape that needs to be constructed

[0077] In order to reconstruct patients with personalized bone defects, CT scans were performed on the bone defects / deformities of the patients before surgery. The CT data is output in DICOM (Digital Imaging and Communications in Medicine) format, and 3D modeling is performed through Medgraphics software and Magic.RP (Magic Rapid Prototyping) software to obtain a 3D bone model. According to the shape of the normal side bone tissue, using mirroring technology, the affected side bone defect is 3D simulated and reconstructed to obtain a 3D model of the normal bone shape of the affected area, and then the bone defect is produced by rapid prototyping ...

Embodiment 3

[0091] Example 3 In vivo nasal bone / cartilage prefabrication and reconstruction of nasal bone

[0092] The specific method is realized through the following technical solutions:

[0093] (1) According to the bone defect, using (CAD / CAM) technology, precise and personalized three-dimensional printing needs to build the tissue shape

[0094] In order to reconstruct a patient with a personalized bone defect, a CT scan of the patient's head is performed before surgery. The CT data is output in DICOM (Digital Imaging and Communications in Medicine) format, and 3D modeling processing is performed through Medgraphics software and Magic.RP (Magic Rapid Prototyping) software to obtain a 3D model of the head soft tissue. According to the normal head tissue shape, a three-dimensional simulation reconstruction process is performed on the nasal defect to obtain a nose shape matching the facial contour. And further communicate with the patient, understand the patient's requirements for the pos...

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Abstract

The invention relates to a method for constructing regenerated nerve vascularized bones, cartilages, joints or body surface organs by a prefabricated female die bracket. Firstly, the female die bracket of a defected tissue or organ is printed in a three-dimension manner by using a computer assisted design/manufacturing technology; then, a surface of a periosteum and/or perichondrium is formed in a body through an operation, the female die bracket is placed and fixedly sutured on a germinal layer of the autologous periosteum and/or perichondrium to form a closed space; after the bones, cartilages, joints or body surface organs whose male die shape corresponds to a female die are regenerated in the space constructed by the female die and the germinal layer of the surface of the periosteum and/or perichondrium, a newly regenerated tissue is taken out, the female die bracket is removed, and the tissue is transplanted to the position of the defected tissue or organ to reconstruct. The newly generated tissue or organ prepared through autologous prefabrication has rich new vessels and nerves, does not contain any exogenous materials participating in tissue regeneration, is high in safety, accurate in shape at the same time, and quite similar to the normal tissue or organ.

Description

technical field [0001] The invention relates to the fields of medicine and bioengineering, in particular to a method for constructing regenerated neurovascularized bone, cartilage, joint or body surface organ. Background technique [0002] Tissue and organ defects and dysfunction caused by various traumas, tumors and other reasons are the main causes of human injury. After human tissues and organs are damaged, how to repair and reconstruct the structure and function of the damaged tissues and organs is a major problem faced by the fields of biology and clinical medicine. Defects of important tissues and organs usually need to be repaired by autologous or allogeneic tissue or organ transplantation, but there are many unavoidable defects in the methods of autologous and allogeneic transplantation, such as insufficient source of donor sites for autologous transplantation, immune rejection, ethical issues etc. [0003] The concept of tissue engineering was proposed in the 1980...

Claims

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Application Information

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IPC IPC(8): A61F2/28A61F2/30A61F2/18A61L27/50
Inventor 魏皎戴传昌李青峰
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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