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Rifamycin sodium combinatorial drug

A technology of rifamycin sodium and medicine, applied in the field of combination medicine of rifamycin sodium and preparation thereof, can solve the problems of increasing product storage cost and transportation cost, inconvenient storage and transportation, unstable storage and the like, and achieves protection Liver tissue and cells, eliminating drug allergic reactions and oxidation, and stable efficacy

Inactive Publication Date: 2014-07-09
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, because rifamycin sodium for injection is not stable in the greenhouse, it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience to storage and transportation, and also increases the product quality. storage and transportation costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Invent a kind of combination medicine of rifamycin sodium, be made up of the effective medicinal ingredient of following parts by weight:

[0025] Rifamycin Sodium 50

[0026] Vitamin C 5

[0027] Glutathione 10

[0028] Propylene Glycol 15

[0029] The method of described rifamycin sodium combination medicine, its preparation method and steps are as follows:

[0030] (1). Take water for injection whose weight is 5-15 times the weight of the rifamycin sodium, and under stirring, dissolve the rifamycin sodium, vitamin C, glutathione and propylene glycol completely respectively to obtain Combination drug solution of rifamycin sodium;

[0031] (2). The medicinal solution obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 1000D, and the filtrate is adjusted to a pH value of 6.7-7.8 with 8% sodium hydroxide solution;

[0...

Embodiment 2

[0038] Invent a kind of combination medicine of rifamycin sodium, be made up of the effective medicinal ingredient of following parts by weight:

[0039] Rifamycin Sodium 62

[0040] Vitamin C 8

[0041] Glutathione 16

[0042] Propylene glycol 20

[0043] The method of described rifamycin sodium combination medicine, its preparation method and steps are as follows:

[0044] (1). Take water for injection whose weight is 5-15 times the weight of the rifamycin sodium, and under stirring, dissolve the rifamycin sodium, vitamin C, glutathione and propylene glycol completely respectively to obtain Combination drug solution of rifamycin sodium;

[0045] (2). The medicinal solution obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 1000D, and the filtrate is adjusted to a pH value of 6.7-7.8 with 8% sodium hydroxide solution;

[0...

Embodiment 3

[0052] Invent a kind of combination medicine of rifamycin sodium, be made up of the effective medicinal ingredient of following parts by weight:

[0053] Rifamycin Sodium 78

[0054] Vitamin C 10

[0055] Glutathione 21

[0056] Propylene glycol 28

[0057] The method of described rifamycin sodium combination medicine, its preparation method and steps are as follows:

[0058] (1). Take water for injection whose weight is 5-15 times the weight of the rifamycin sodium, and under stirring, dissolve the rifamycin sodium, vitamin C, glutathione and propylene glycol completely respectively to obtain Combination drug solution of rifamycin sodium;

[0059] (2). The medicinal solution obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 1000D, and the filtrate is adjusted to a pH value of 6.7-7.8 with 8% sodium hydroxide solution;

[...

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PUM

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Abstract

The invention provides a rifamycin sodium combinatorial drug. The rifamycin sodium combinatorial drug is characterized in that the rifamycin sodium combinatorial drug is prepared from rifamycin sodium, vitamin C, sodium pyrosulfite and propylene glycol as active components according to a weight part ratio of rifamycin sodium, vitamin C, sodium pyrosulfite to propylene glycol of 50-120: 5-15: 10-30: 15-40. The invention also provides a preparation method of the rifamycin sodium combinatorial drug. The rifamycin sodium combinatorial drug is superior to drugs prepared by the prior art in safety, stability and curative effects. The preparation method saves energy and is environmentally friendly.

Description

technical field [0001] The invention relates to a combination medicine of rifamycin sodium and a preparation method thereof. Background technique [0002] Rifamycin sodium has an antibacterial effect on Gram-positive cocci such as Staphylococcus aureus and Staphylococcus epidermidis. Gram-negative to Escherichia coli, Serratia, Shigella, Yersinia, Pseudomonas aeruginosa, Klebsiella pneumoniae, Enterobacter aerogenes, Vibrio and Aeromonas Bacteria also have strong antibacterial activity. Rifamycin sodium can inhibit the early synthesis of bacterial cell walls. Its molecular structure is similar to that of phosphoenolpyruvate, so it can compete with bacteria for the same transferase, inhibiting the synthesis of bacterial cell walls and leading to bacterial death. At present, because rifamycin sodium for injection is not stable in the greenhouse, it is easily damaged when exposed to external forces such as light, heat, water, oxidation, etc., which brings great inconvenience ...

Claims

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Application Information

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IPC IPC(8): A61K47/42A61K47/22A61K47/10A61K31/395A61P31/04
Inventor 邓学峰
Owner 邓学峰
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