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Ceftriaxone combinatorial drug

A technology of ceftriaxone and medicine, which is applied in the field of combination medicine of ceftriaxone and its preparation, can solve the problems of easy destruction, inconvenient storage and transportation, unstable storage, etc., and achieve the effect of no pyrogen reaction

Inactive Publication Date: 2014-07-09
邓学峰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, ceftriaxone for injection is not stable when stored in a greenhouse, and is easily damaged when exposed to external forces such as light, heat, water, and oxidation, which brings great inconvenience to storage and transportation, and also increases product storage costs. and shipping costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Invent a kind of combination medicine of ceftriaxone, be made up of the effective medicinal ingredient of following parts by weight:

[0024] Ceftriaxone 53

[0025] 2-Hydroxypropyl-β-cyclodextrin 5

[0026] Tiopronin 6

[0027] The method of described ceftriaxone combination medicine, its preparation method and steps are as follows:

[0028] (1). Take water for injection whose weight is 5-15 times that of the ceftriaxone, and dissolve the ceftriaxone, 2-hydroxypropyl-β-cyclodextrin and tiopronin completely under stirring. , to obtain a combined drug solution of ceftriaxone;

[0029] (2). The medicinal solution obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 1000D, and the filtrate is adjusted to a pH value of 6.7-7.8 with 8% sodium hydroxide solution;

[0030] (3). The liquid medicine obtained in step (2) was stea...

Embodiment 2

[0036] Invent a kind of combination medicine of ceftriaxone, be made up of the effective medicinal ingredient of following parts by weight:

[0037] Ceftriaxone 62

[0038] 2-Hydroxypropyl-β-cyclodextrin 6.3

[0039] Tiopronin 8

[0040] The method of described ceftriaxone combination medicine, its preparation method and steps are as follows:

[0041] (1). Take water for injection whose weight is 5-15 times that of the ceftriaxone, and dissolve the ceftriaxone, 2-hydroxypropyl-β-cyclodextrin and tiopronin completely under stirring. , to obtain a combined drug solution of ceftriaxone;

[0042] (2). The medicinal solution obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 1000D, and the filtrate is adjusted to a pH value of 6.7-7.8 with 8% sodium hydroxide solution;

[0043] (3). The liquid medicine obtained in step (2) was st...

Embodiment 3

[0049] Invent a kind of combination medicine of ceftriaxone, be made up of the effective medicinal ingredient of following parts by weight:

[0050] Ceftriaxone 78

[0051] 2-Hydroxypropyl-β-cyclodextrin 7.8

[0052] Tiopronin 11

[0053] The method of described ceftriaxone combination medicine, its preparation method and steps are as follows:

[0054] (1). Take water for injection whose weight is 5-15 times that of the ceftriaxone, and dissolve the ceftriaxone, 2-hydroxypropyl-β-cyclodextrin and tiopronin completely under stirring. , to obtain a combined drug solution of ceftriaxone;

[0055] (2). The medicinal solution obtained in step (1) is ultrafiltered with an ultrafiltration membrane with a molecular weight cut-off of 4000D, and the filtrate is ultrafiltered with a membrane with a molecular weight cut-off of 1000D, and the filtrate is adjusted to a pH value of 6.7-7.8 with 8% sodium hydroxide solution;

[0056] (3). The liquid medicine obtained in step (2) was s...

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PUM

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Abstract

The invention provides a ceftriaxone combinatorial drug. The ceftriaxone combinatorial drug is characterized in that the ceftriaxone combinatorial drug is prepared from ceftriaxone, 2-hydroxypropyl-beta-cyclodextrin and tiopronin as active ingredients according to a weight part ratio of ceftriaxone, 2-hydroxypropyl-beta-cyclodextrin to tiopronin of 53-98: 5-11: 6-19. The invention also provides a preparation method of the ceftriaxone combinatorial drug. The ceftriaxone combinatorial drug is superior to the existing drug prepared by the prior art in safety, stability and curative effects and can be prepared by an energy-saving and eco-friendly preparation method.

Description

technical field [0001] The invention relates to a combination medicine of ceftriaxone and a preparation method thereof. Background technique [0002] Ceftriaxone Sodium (Rocephin) is a third-generation cephalosporin antibiotic, used for lower respiratory tract infection, urinary tract, biliary tract infection caused by sensitive pathogenic bacteria, as well as abdominal infection, pelvic infection, skin and soft tissue infection, Bone and joint infection, sepsis, meningitis, etc. and infection prevention during surgery. Similar drugs include ceftriaxone, ceftriaxone, junbizhi, thiatriazine, cephalosporins, ceftaxone, etc. At present, ceftriaxone for injection is not stable when stored in a greenhouse, and is easily damaged when exposed to external forces such as light, heat, water, and oxidation, which brings great inconvenience to storage and transportation, and also increases product storage costs. and shipping costs. In addition, those with drug allergies, adverse reac...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/40A61K31/546A61K47/18A61K9/19A61K9/08A61K9/12A61P31/04A61P11/00A61P13/02A61P1/16A61P1/00A61P15/00A61P17/00A61P19/02A61P19/00A61P3/02
Inventor 邓学峰
Owner 邓学峰
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