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Pharmaceutical composition as well as preparation method and application thereof

A composition and drug technology, applied in the direction of drug combination, drug formulation, drug delivery, etc., can solve problems such as inaccurate quantitative detection methods, primitive pharmaceutical technology, and difficult quality control, so as to reduce the formation of new stones, improve kidney function, The effect of suppressing the amount

Inactive Publication Date: 2014-07-02
HUMANWELL HEALTHCARE GRP +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above traditional Chinese patent medicines, like Shilintong Tablets, still have problems such as primitive pharmaceutical technology, difficult quality control, inaccurate quantitative detection methods, and large dosages. They are far from international standards and do not meet modern clinical conditions. Medication requirements
[0003] Currently, the drugs used to treat urolithiasis still need to be improved

Method used

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  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof
  • Pharmaceutical composition as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Embodiment 1, the preparation of total flavonoids of Desmodium radix

[0058] (1) Extraction method: According to the solubility of flavonoids, free flavonoids and flavonoid glycosides can generally be extracted with organic solvents, and industrial production usually uses higher concentration of ethanol for extraction. This study is based on the general industrial extraction method of flavonoids On the basis of that, 60%-95% ethanol is selected as the extraction solvent, and the number of extraction times is more economical and practical to extract twice according to the common production method.

[0059] Ethanol reflux extraction process experiment: using L9 (3 4 ) Orthogonal test method, taking the total flavonoids of Desmodium sativa as the investigation index, determine the process parameters of factors such as ethanol concentration, ethanol consumption (multiple of the amount of Desmodium sativa) and extraction time, and adopt the ultraviolet-visible spectrophotom...

Embodiment 2

[0101] Embodiment 2, the preparation of total flavonoids of Desmodium radix

[0102] Take 50 grams of Herba Desmanthus herb, add 12 times the amount of 80% ethanol for the first time, heat and reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat and reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, so that the volume of the medicinal solution is 5 times the amount of medicinal materials, stand and filter to obtain the filtrate (which is the loading medicinal solution), and set aside. Soak 100 kg of pharmaceutical grade AB-8 macroporous resin with an appropriate amount of ethanol, wet-pack the column, and treat it for later use. Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the column bed volume per hour. 60% ethanol in the bed volume was eluted at a flow rate of 2 times the column bed...

Embodiment 3

[0103] Embodiment 3, the preparation of total flavonoids of Desmodium radix

[0104] Take 200 grams of Desmodium sativa, add 12 times the amount of 80% ethanol for the first time, heat and reflux at 55°C for 2 hours, add 10 times the amount of 80% ethanol for the second time, heat and reflux at 55°C for 1.5 hours, Combine the alcohol extracts; concentrate the alcohol extracts to a certain volume, so that the volume of the medicinal solution is 5 times the amount of medicinal materials, stand and filter to obtain the filtrate (which is the loading medicinal solution), and set aside. Soak 400 grams of pharmaceutical grade AB-8 macroporous resin with an appropriate amount of ethanol, wet-pack the column, and prepare it for later use.

[0105] Pass the above-mentioned filtrate (loading drug solution) through the AB-8 macroporous adsorption resin column at a flow rate of 2 times the column bed volume per hour. 60% ethanol in the bed volume was eluted at a flow rate of 2 times the ...

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Abstract

The invention provides a medicinal composition as well as a preparation method and application thereof. The pharmaceutical composition is a medicinal preparation for clinical administration, which is prepared from desmodium styracifolium general flavone extract serving as an active component and pharmaceutically acceptable medicinal auxiliaries. The composition can be used for preparing clinical treatment medicament for clearing damp-heat, promoting diuresis and expelling stone (damp-heat stagnation).

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a pharmaceutical composition and its preparation method and application. More specifically, the present invention provides a pharmaceutical composition, the use of the pharmaceutical composition in the preparation of medicaments and a method for preparing the pharmaceutical composition. Background technique [0002] Desmodium styracifolium (Osb.) Merr. is a leguminous plant. The dry aerial part of Desmodium styracifolium (Osb.) Merr. is a traditional Chinese medicine recorded in the 2010 edition of "Chinese Pharmacopoeia". . Simultaneously recorded prescription Shilintong Tablets, the main ingredient of which is Desmodium sativa, is used for bladder damp-heat, Shilin astringent pain, urinary tract stones, urinary tract infection belongs to hepatobiliary bladder damp-heat. However, the preparation of the raw material of Shilintong Tablets is the crude extr...

Claims

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Application Information

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IPC IPC(8): A61K36/48A61K9/28A61K9/22A61K9/30A61K9/46A61K9/48A61K9/16A61K9/14A61P13/04A61P13/00
CPCA61K31/352A61K9/1623A61K9/2054A61K9/4875A61K9/1635A61K9/2027A61K9/4866A61K36/48A61K2236/33A61P13/00A61P13/04A61K9/1682A61K9/2893A61K9/4833A61K2236/333A61K2236/39A61K2236/51A61K2236/55A61K2236/37A61K31/353
Inventor 王学海李杰李莉娥许勇涂荣华陈刚曹儒宾冯芸杨仲文范昭泽余艳平肖强黄璐杨成兵黄天赐田华杨菁
Owner HUMANWELL HEALTHCARE GRP
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