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MRI development embolism microballoon based on gadolinium alginate

A technology of alginic acid and sodium alginate, applied in preparations for in vivo experiments, medical science, emulsion delivery, etc., can solve the problems of not truly reflecting the effect of embolic materials, missing the best treatment period for patients, and toxic and side effects , to achieve the effect of intuitive visual controllability, good biodegradability and good biocompatibility

Inactive Publication Date: 2014-06-18
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The separation of the contrast agent from the embolic material makes the observed results of the contrast agent not truly reflect the effect of the embolic material, and the free contrast agent will also have certain toxic side effects on the body
[0009] (2) Embolization first and then treatment in clinical practice may cause delay in treatment
The separation of treatment and detection prolongs the treatment cycle, making it easy for patients to miss the best treatment period and delay the treatment of the disease

Method used

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  • MRI development embolism microballoon based on gadolinium alginate
  • MRI development embolism microballoon based on gadolinium alginate
  • MRI development embolism microballoon based on gadolinium alginate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Preparation of Gadolinium Alginate Gel Beads Containing MRI Visualizable Groups:

[0031] 1. Solution preparation

[0032] 1) 0.1mol / L GdCl 3 Solution: Take 13.18g (0.05mol) of GdCl 3 , dissolved in 500mL deionized water, after complete dissolution, filtered through a 0.22μm membrane filter, and the filtrate was collected for later use.

[0033] 2) 1.5% (w / v) sodium alginate solution: Take 1.5g of sodium alginate, dissolve it in 100mL of deionized water, stir to dissolve it completely, filter it with 0.8μm, 0.45μm, and 0.22μm filter membranes successively, and collect The filtrate was degassed overnight in a refrigerator at 4°C.

[0034] 2. Bead preparation

[0035] 1) Take the 1.5% (w / v) sodium alginate solution out of the refrigerator to return to room temperature, draw 2mL sodium alginate solution with a 5mL syringe, connect the standard 5# needle, place it at the designated position of the electrostatic droplet generator, and adjust the pump speed to 12.7mL / h. ...

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Abstract

The invention discloses preparation of a magnetic resonance imaging (MRI) developpable microbead and application potential of the microbead to tumour arterial embolism treatment. Sodium alginate is taken as a raw material, the microbead is formed by employing an electrostatic drop generator, and on the basis, lanthanide metal ion such as Gd<3+> is introduced as a development group for MRI imaging, so that visualization of embolism treatment process is realized.

Description

technical field [0001] The invention relates to the preparation of visualized tumor embolization microspheres, specifically, on the basis of alginic acid embolization microspheres, MRI-developable components are introduced to realize the visualization of embolization therapy. Background technique [0002] In 1971, Folkman proposed the theory of neovascularization of tumors (Document 1: Judah Folkman, N Engl J Med 1971; 285:1182-1186), that is, tumor growth depends on neovascularization. Neovascularization not only provides nutrients for tumor growth, but also serves as a channel for primary tumor metastasis and a prerequisite for the proliferation of metastatic foci. Arterial embolization therapy is aimed at this characteristic of tumors. Under the guidance of medical imaging means, embolization materials are selectively injected into the supply vessels of diseased organs or into diseased blood vessels through catheters, interrupting blood supply, and finally achieving the g...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/04A61L31/14A61K49/12A61K49/18
Inventor 马小军谭明乾王艳妨
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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