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Antiallergic drug sustained release suspension and preparation method of suspension

A slow-release suspension and anti-allergic technology, which can be used in drug combinations, pharmaceutical formulas, allergic diseases, etc., and can solve problems such as uncontrollable drug release, increased energy consumption, and unfavorable quality control.

Active Publication Date: 2014-06-18
AC PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the heat healing (curing) time of the coating is too long (the heat treatment time is several times or even dozens of times longer than the general coating time), which may affect the stability of the drug, which is not conducive to quality control, and also greatly increased energy consumption
[0019] Moreover, the formula or preparation process of the above-mentioned preparations has the problems of being unable to control the stable release of the drug in the gastrointestinal tract, preventing the dissolution of the drug from the carrier into the liquid matrix during storage, and high energy consumption.

Method used

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  • Antiallergic drug sustained release suspension and preparation method of suspension
  • Antiallergic drug sustained release suspension and preparation method of suspension
  • Antiallergic drug sustained release suspension and preparation method of suspension

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0069] Example 1 Preparation of drug-ion exchange resin complex.

[0070] Preparation steps: (1): Dissolve 166.67g of carbinoxamine maleate in 1L of purified water; (2): Take 500g of Amberlire IRP-69 resin passed through a 80-mesh sieve, and add it to the solution obtained in (1) under stirring , continuously stirred for 4 hours, stood still, and filtered to obtain a jelly; (3): Add 2L of purified water to the jelly obtained in step (2), stir slowly for 10min, remove the supernatant, and repeat step (3) Operation 1 (4): Dry the drug-resin complex obtained in (3) at 45°C until the water content is 5%, and store it in a sealed and dry place.

Embodiment 2

[0071] Example 2 Preparation of drug-containing core.

[0072] Preparation steps: (1): Dissolve 166.67g of carbinoxamine maleate in 1L of purified water; (2): Take 500g of Amberlire IRP-69 resin passed through a 80-mesh sieve, and then add it to the obtained product in (1) under stirring In the solution, stir continuously for 4 hours, let it stand, and filter to obtain a jelly; (3): Add 2L of purified water to the jelly obtained in (2), stir slowly for 10min, remove the supernatant, and repeat step (3) Operation 1 (4): Dry the drug-resin complex obtained in (3) at 45°C until the water content is 50%; (5): 15.00g of sodium alginate passed through a 80-mesh sieve and 3.22 Add g of povidone slowly to the drug-resin complex obtained in (4) under stirring, and stir evenly; (6): Dry the mixture obtained in (5) at 45°C to a water content of 25%, and grind it with a grinder for about After 10 minutes, pass through an 80-mesh sieve, then dry at 45°C until the water content is 5%, grin...

Embodiment 3

[0073] Example 3 Preparation of drug-containing core.

[0074] Preparation steps: (1): Dissolve 166.67g of carbinoxamine maleate in 1L of purified water; (2): Mix 500.00g of Amberlire IRP-69 and 15.00g of sodium alginate resin through an 80-mesh sieve, and then Add to the solution obtained in (1) under stirring, continue to stir for 4 hours, stand still, and filter to obtain a jelly; (3): Add 2L of purified water to the jelly obtained in (2), stir slowly for 10 minutes, and remove the supernatant , repeat step (3) once; (4): dry the jelly obtained in (3) at 45°C until the water content is 50%; (5): pass 3.22g of methyl cellulose Slowly add to the drug jelly obtained in (4) under stirring, and stir evenly; (6): Dry the mixture obtained in (5) at 45°C until the water content is 25%, grind it with a grinder for about 10 minutes, and pass through 80 mesh Sieve, then dry at 45°C to a water content of 5%, grind for 10 minutes with a grinder, and pass through an 80-mesh sieve to obtai...

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Abstract

The invention discloses an antiallergic drug sustained release suspension and a preparation method of the suspension. The suspension is prepared from drug-containing particles and a slightly neutral or alkaline suspension matrix, wherein each drug-containing particle respectively comprises a drug-containing core, an isolating coating and a sustained release coating from inside to outside, the drug-containing core comprises a drug, insoluble cation exchange resin, an alkaline soluble polymer and an adhesive, the isolating coating comprises an insoluble polymer, an alkaline soluble polymer, an acid-soluble polymer, a plasticizer and an antisticking agent, the sustained release coating comprises an insoluble polymer, an acid-soluble polymer, a plasticizer and an antisticking agent, and the suspension matrix comprises an alkaline modifier, an acid-soluble polymer, a thickener, a lubricant, a matrix and the like. According to the suspension, the purpose of stabilizing blood concentration by controlling the drug to be released in the gastrointestinal tract through the ion exchange resin, the alkaline soluble polymer and the sustained release coating.

Description

technical field [0001] The invention relates to a slow-release suspension of medicine, in particular to a slow-release suspension of antiallergic medicine and a preparation method thereof. Background technique [0002] Carbinoxamine is a mild and sedative ethanolamine antihistamine drug, which has significant sedative and anticholinergic effects, and has low gastrointestinal side effects. It has been proven safe and effective. Carbinoxamine has been widely used, and there are currently more than 100 marketed products containing carboxamine, including sustained-release solid preparations and compound preparations. [0003] Carbinoxamine maleate is N-[2-[(4-chlorophenyl)(2-pyridyl)methoxy]ethyl]-N,N-dimethylamine maleate with a molecular weight of 406.87 , the molecular formula is C 16 h 19 C l N 2 O·C 4 h 4 o 4 , White odorless crystal, soluble in water (1:1), ethanol (1:1.5), chloroform (1:1.5), slightly soluble in ether (1:8300). [0004] Carbinoxamine is very effe...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/4402A61K47/38A61K47/36A61K47/32A61P37/08
Inventor 刘锋赖树挺郑阳周伟杰
Owner AC PHARMA CO LTD
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