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Esters for treatment of ocular inflammatory conditions

An eye disease, ophthalmology technology, applied in the field of eye products, can solve problems such as disorders, bleeding time effects, increased cholesterol levels, etc.

Inactive Publication Date: 2014-05-14
JOHNSON & JOHNSON VISION CARE INC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, oral omega-3 fatty acids do have potential side effects such as effects on bleeding time, increased cholesterol (LDL) levels, high caloric intake, fishy taste, and gastrointestinal disturbances

Method used

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Examples

Experimental program
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Embodiment Construction

[0015] Methods of making and using ophthalmic products comprising esterified anti-inflammatory lipid mediators, wherein the majority of the anti-inflammatory lipid mediators are present in the ester form are provided. It has been found that the use of esterified anti-inflammatory lipid mediators (when the majority of the anti-inflammatory lipid mediator is present in the ester form) results in ophthalmic products with greatly improved initial comfort upon contact with or application to ocular surfaces . Ophthalmic products include, but are not limited to, any formulation, solution, gel, ointment, lotion, strip, ophthalmic device, etc. that can be applied to ocular surfaces, including the eye.

[0016] With respect to terms used in this disclosure, the following definitions are provided.

[0017] References to "anti-inflammatory lipid mediators" include those molecules that inhibit (directly or indirectly) the production of cytokines by epithelial or immune cells, inhibit the ...

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PUM

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Abstract

The present invention relates to ophthalmic compositions and methods for the treatment of dry eye and other inflammatory ocular conditions. In particular, the present invention relates to a composition comprising an esterified anti-inflammatory lipid mediator, which is an ester of an anti-inflammatory lipid mediator that is a reaction product of the anti-inflammatory lipid mediator and a polyol wherein the majority of the anti-inflammatory lipid mediator is present in an ester form. In this way, the compositions are substantially free of an acid form of the anti-inflammatory lipid mediators. Anti-inflammatory lipid mediators can be selected from the group consisting of polyunsaturated fatty acids (e.g., omega-three and omega-six fatty acids), resolvins or a metabolically stable analog, protectins or a metabolically stable analog, lipoxins or a metabolically stable analog, prostaglandins or a metabolically stable analog, retinoic acids, endocannabinoids, metabolites thereof, and mixtures thereof. This composition can be topically delivered to the ocular surface via a preparation, solution, gel, ointment, and / or strip and / or a contact lens.

Description

[0001] related application [0002] This application claims priority to US Patent Application Serial No. 13 / 495,052, filed June 13, 2012, and US Provisional Patent Application Serial No. 61 / 503,158, filed June 30, 2011. technical field [0003] The present invention relates to ophthalmic products comprising esterified anti-inflammatory lipid mediators for relief of dry eye or treatment of inflammatory ocular conditions. An ophthalmic composition comprising an esterified anti-inflammatory lipid medium is provided. Also provided are sterile formulations, solutions, gels, ointments, and / or strips for administration to the eye, and / or contact lenses comprising an esterified anti-inflammatory lipid vehicle. Background technique [0004] Adequate lubrication is known to be essential for good eye health. Tears nourish the tissues of the eye and protect the surface of the eye from foreign objects. Changes to the surface of the eye caused by changes in tear quality or quantity (ca...

Claims

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Application Information

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IPC IPC(8): A61K9/00A61K31/16A61K31/201A61K31/202A61K31/203A61K31/557A61P27/02A61P27/04
CPCA61K9/0048A61K9/08A61K31/232A61K31/765A61K47/22A61K47/26A61K2300/00A61K31/557A61K31/215A61K31/5575A61K31/661A61P27/00A61P27/02A61P27/04A61P29/00A61K31/201A61K31/202A61K31/203A61K31/16A61K9/0051A61K31/683A61K9/00A61K31/21A61K31/25A61J3/00A61K47/14
Inventor A.盖洛伊斯-伯诺斯
Owner JOHNSON & JOHNSON VISION CARE INC
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