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Optical fiber surface plasma resonance sensor, detection system and method

A detection system and sensor technology, which is applied in the direction of instruments, measuring devices, scientific instruments, etc., can solve the problems of insufficient detection performance and reliability of optical fiber SPR, and achieve the effect of simple and reliable, lower detection limit, and lower baseline noise

Active Publication Date: 2014-05-14
SHENZHEN UNIV
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Problems solved by technology

[0003] In view of this, the main purpose of the present invention is to provide an optical fiber SPR sensor, detection system and method, which can solve the problems of insufficient detection performance and reliability of the existing optical fiber SPR

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  • Optical fiber surface plasma resonance sensor, detection system and method
  • Optical fiber surface plasma resonance sensor, detection system and method
  • Optical fiber surface plasma resonance sensor, detection system and method

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Embodiment Construction

[0019] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail by citing the following embodiments and referring to the accompanying drawings.

[0020] figure 1 The structure of the optical fiber SPR detection system of the present invention is shown, as figure 1 As shown, the optical fiber SPR detection system sequentially includes along the optical path direction: a light source, a polarizer, a phase retarder, a collimator, a sample cell, the above-mentioned optical fiber SPR sensor, a polarizer, a detector, a lock-in amplifier and PC systems.

[0021] The optical fiber SPR sensor is immersed in a sample pool full of the solution to be detected, the sample pool is provided with a liquid inlet and a liquid outlet, and the solution to be detected continuously flows in from the liquid inlet and flows out from the liquid outlet during detection; The optical fiber SPR sensor inclu...

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Abstract

The invention provides an optical fiber surface plasma resonance (SPR) sensor, a detection system and a detection method. The optical fiber SPR sensor comprises an all-solid-state refractive index guiding type photonic crystal fiber with a planar wall and a curved side wall, the cross section of the all-solid-state refractive index guiding type photonic crystal fiber is D-shaped, and the planar wall is provided with a sensing layer. A sensing plane is prepared on the surface of the D-shaped photonic crystal fiber, the excitation strength of the SPR can be regulated by controlling the distance between the SPR sensing plane and an optical fiber core, and the phase sensitivity measurement can be realized by utilizing horizontal and perpendicular component interference of electromagnetic wave. The optical fiber surface plasma resonance detection device is simple and reliable in preparation technique of the sensor, high in sensitivity, strong in anti-interference capability, and better in resolution compared with the traditional wavelength demodulation mode, thus having strong application values.

Description

technical field [0001] The invention relates to the technical field of photoelectric detection, in particular to an optical fiber surface plasmon resonance (Surface Plasmon Resonance, SPR) sensor, detection system and method. Background technique [0002] SPR is a new sensing technology, which has the advantages of high sensitivity, high throughput, easy to achieve specific detection and real-time performance, and does not require labeling. It has been widely used in biology, medicine, food quality and safety, chemical and environmental monitoring, etc. Industry, especially online real-time detection of interactions between DNA and proteins, between protein molecules, and between biomolecules such as drug-protein, nucleic acid-nucleic acid, antigen-antibody, receptor-ligand, etc. At present, the SPR demodulation based on optical fiber mainly adopts the wavelength demodulation method. Since the wavelength shift is an apparent and overall SPR effect, its detection performance ...

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Application Information

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IPC IPC(8): G01N21/552
CPCG01N21/553G01N21/05
Inventor 谭志新李学金邵永红
Owner SHENZHEN UNIV
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