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Preparation method of Danshitongli tablet and application of Danshitongli tablet in preparing drugs for inhibiting leukaemia cell P815 from cell proliferation

An extraction technology for Danshi Tongli Tablets, which is applied in the direction of antineoplastic drugs, drug combinations, and medical preparations containing active ingredients, etc., can solve the problems of large dosage for patients, rough craftsmanship, and backwardness, and achieve the effect of reducing dosage

Inactive Publication Date: 2014-05-07
JINAN XINQIDIAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no gallstone tongli capsule that adopts ultrafine pulverization, CO 2 There are reports on supercritical extraction, microwave technology and macroporous resin adsorption technology. However, the traditional Chinese medicine is directly extracted by powdering and decocted in water. The process is rough and backward, and there are many impurities, which leads to excessive dosage for patients and is inconvenient to take. products in clinical application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 200min, and the supercritical extract is obtained for use; after extraction, frankincense, myrrh residue and other nine medicinal materials are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 700W, extraction 2 times, 8 minutes e...

Embodiment 2

[0034] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the extracted frankincense, myrrh residue and other nine herbs are crushed, added 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 600W, extraction 2 times, 8 minutes each time, combined extr...

Embodiment 3

[0037] Take 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, 35g Myrrh: Mix Glauber’s Salt, Alum Superfinely pulverize into fine powder with a particle size range of 5-45 μm for later use; take frankincense and myrrh, pulverize into fine powder, and add to CO 2In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 6%, the extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 220min, and the supercritical extract is obtained for later use; the extracted frankincense, myrrh residue and other nine herbs are crushed, added with 3.6L of 70% ethanol, and put into a microwave extraction device for extraction. Microwave extraction, extraction power 800W, extraction 2 times, 10 minutes each time, co...

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Abstract

The invention belongs to the technical field of traditional Chinese medicines, and particularly provides a preparation method and application of a Danshitongli tablet. The preparation method comprises the following steps: by using 225g of Herba Lysimachiae, 225g of oriental wormwood, 90g of radix curcumae, 150g of dried orange peel, 45g of radix scutellariae, 35g of frankincense, 80g of mirabilite, 35 of white alum, 45g of rhubarb, 45g of rhizoma sparganii, 45g of gardenia, 25g of licorice and 35g of myrrh as active pharmaceutical ingredients, carrying out superfine grinding, supercritical extraction, microwave extraction and macroporous resin adsorption so that the hesperidin content is greatly enhanced. The invention also provides application of the Danshitongli tablet in preparing drugs for inhibiting mouse leukaemia cell P815 from cell proliferation.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine, and in particular relates to a preparation method of Danshi Tongli Tablet and its application in the preparation of a medicine for inhibiting the proliferation of mouse mast cell tumor cell P815 cells. Background technique [0002] The standard number of Danshi Tongli Capsules is WS-10324 (ZD-0324)-2002, which is recorded in the Hepatobiliary Subvolume of the National Compilation of Chinese Patent Standards. Made from 225g Desmodium, 225g Capillary, 90g Curcuma, 150g Chenpi, 45g Scutellaria, 35g Frankincense, 80g Glauber’s Salt, 35g Alum, 45g Rhubarb, 45g Sanleng, 45g Gardenia, 25g Licorice, and 35g Myrrh. , has the effect of clearing heat and gallbladder, removing blood stasis and removing stones. For acute and chronic cholecystitis and gallstones caused by damp-heat in the liver and gallbladder. [0003] In the prior art, there is no gallstone tongli capsule that adopts u...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/20A61P1/16A61P35/00A61K33/06A61K33/04
Inventor 孙波
Owner JINAN XINQIDIAN MEDICAL TECH
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