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Application of osmanthus phenylethanoid glycoside extract in preparing anti-aging drugs or health products

A technology of phenylethanol glycosides and total phenylethanol glycosides from osmanthus fragrans, applied in the field of preparation of anti-aging drugs or health care products, phenylethanol glycoside extracts, can solve the impact of extraction yield and extract purity, and does not pay attention to the stability of phenylethanol glycoside compounds and other issues, to achieve the effect of good quality, clear composition and wide application

Active Publication Date: 2014-05-07
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, in the traditional extraction of osmanthus polyphenols, no attention has been paid to the stability of phenylethanol glycosides, which affects the extraction yield and purity of the extract. Therefore, measures need to be taken during the extraction process to prevent the oxidation and decomposition of phenylethanol glycosides

Method used

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  • Application of osmanthus phenylethanoid glycoside extract in preparing anti-aging drugs or health products
  • Application of osmanthus phenylethanoid glycoside extract in preparing anti-aging drugs or health products
  • Application of osmanthus phenylethanoid glycoside extract in preparing anti-aging drugs or health products

Examples

Experimental program
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Effect test

Embodiment 1

[0063] Crush 1 kg of dried Jingui flowers (moisture content ≤ 10%, crushed to pass through a 20-mesh sieve), add 15L of 80% (volume %) ethanol aqueous solution, and then add 0.1% sodium erythorbate aqueous solution (that is, each 1 liter of sodium erythorbate aqueous solution contains 1g of sodium erythorbate) 2L, use 1mol / L formic acid aqueous solution to adjust the pH of the extraction solution to about 5; extract at a temperature of 50°C to 80°C for 2 hours, cool to room temperature, and filter to obtain the extract Liquid; Concentrate the extract directly under reduced pressure (at 0.010-0.100MPa, temperature 50-60°C), recover ethanol to obtain a concentrated solution (about 4L), then dilute with water until the pH of the diluted solution is about 5; The liquid is absorbed by the adsorption resin (the adsorption resin is HPD300, the dosage is 1L), and it is eluted with 2L of 30% (volume %) ethanol aqueous solution; ), after spray drying (inlet air temperature is 180-200°C,...

Embodiment 2

[0082] Crush 1 kg of dried osmanthus osmanthus (water content ≤ 10%, crushed to pass through a 20-mesh sieve), add 10 L of 90% (volume %) ethanol aqueous solution, and then add 0.2% ascorbic acid aqueous solution (that is, each liter of ascorbic acid aqueous solution containing 2g ascorbic acid) 2L, use 0.5mol / L acetic acid aqueous solution to adjust the pH of the extraction solution to about 4; extract at a temperature of 50°C to 80°C for 2 hours, cool to room temperature, and filter to obtain the extract; directly extract the extract Concentrate under reduced pressure (at 0.010-0.100MPa, temperature 50-60°C), recover ethanol, obtain a concentrated solution (about 1.5L), and then dilute with water until the pH of the diluted solution is about 4; absorb the diluted solution with an adsorption resin (The adsorption resin is HPD300, the dosage is 1L), and it is eluted with 2L of 30% (volume %) ethanol aqueous solution; After microwave drying (process parameters: microwave power ...

Embodiment 3

[0085] Crush 1 kg of dried Osmanthus osmanthus (water content ≤ 10%, crushed to pass through a 20-mesh sieve), add it to 10 L of 90% (volume %) ethanol solution, and then add 0.1% bamboo leaf antioxidant aqueous solution (that is, the Each liter of bamboo leaf antioxidant aqueous solution contains 1g of bamboo leaf antioxidant) 2L, using 1mol / L acetic acid aqueous solution to adjust the pH of the extraction solution to about 5; the extraction solution is obtained; the extraction solution is carried out at a temperature of 50°C to 80°C Leach for 2 hours, cool to room temperature, and filter to obtain the extract; directly concentrate the extract under reduced pressure (at 0.010-0.100MPa, temperature 50-60°C), recover ethanol, and obtain a concentrate (about 2.5L), Then dilute with water until the pH of the diluted liquid is about 4; absorb the diluted liquid with an adsorption resin (the adsorption resin is HPD300, the dosage is 1 L), and elute with 2 L of 30% (volume %) ethanol...

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Abstract

The invention discloses application of an osmanthus phenylethanoid glycoside extract in preparing anti-aging drugs or health products. The total phenylethanoid glycoside content in the osmanthus phenylethanoid glycoside extract is 30-90 wt%, and the total phenylethanoid glycosides comprise verbascoside and isoverbascoside. The verbascoside content in the osmanthus phenylethanoid glycoside extract is 25-80 wt%, and the weight ratio of the verbascoside to the isoverbascoside in the total phenylethanoid glycosides is 48:1-300:1.

Description

technical field [0001] The invention relates to the field of intensive processing and comprehensive utilization of agricultural and sideline products. More specifically, it relates to a phenylethanol glycoside extract extracted from osmanthus fragrans and its preparation method and application—for preparing anti-aging medicine or health care product. Background technique [0002] Osmanthus fragrans, also known as sweet-scented osmanthus and rock osmanthus, is one of the top ten traditional Chinese flowers. It is widely planted in the Huaihe River Basin and the areas to the south. At present, my country has formed Hangzhou in Zhejiang, Lu'an in Anhui, Xianning in Hubei, Taoyuan in Hunan, Suzhou in Jiangsu, and Guilin in Guangxi. Several major osmanthus commodity production bases such as Wuhan, Hubei and Chengdu, Sichuan. There are many varieties of osmanthus, about 152 varieties, which can be divided into four strains, namely Sijigui, Dangui, Yingui and Jingui. In addition t...

Claims

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Application Information

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IPC IPC(8): A61K36/63A61P39/06A23L1/30A23L33/10
Inventor 陆柏益毛淑琴蒋易蓉熊丽娜周菲杨佳佳胡银洲谌灿曦孙启鸿
Owner ZHEJIANG UNIV
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