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Application of cobra snake venom cardiotoxins cardiotoxins in the preparation of anti-inflammatory, analgesic and anti-arthritic drugs

A technology of cobra snake venom and cardiotoxin, applied in anti-inflammatory agents, drug combinations, antipyretics, etc., to achieve high potency, good analgesic effect, and large effective range

Active Publication Date: 2016-01-20
SUZHOU RENBEN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The effect of cobra venom cardiotoxin on anti-inflammatory, analgesic and anti-arthritis has not been reported

Method used

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  • Application of cobra snake venom cardiotoxins cardiotoxins in the preparation of anti-inflammatory, analgesic and anti-arthritic drugs
  • Application of cobra snake venom cardiotoxins cardiotoxins in the preparation of anti-inflammatory, analgesic and anti-arthritic drugs
  • Application of cobra snake venom cardiotoxins cardiotoxins in the preparation of anti-inflammatory, analgesic and anti-arthritic drugs

Examples

Experimental program
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Effect test

Embodiment

[0034] (1) The hot plate pain model is one of the common methods to study the analgesic effect of drugs. Place the mice on a hot plate at 55±1°C, record the time from when the rats are placed on the hot plate to licking the hind paw reaction as the pain threshold, measure the basic pain threshold before administration, and keep the basic pain threshold between 5 and 30s Mice within the range were eliminated, and 60s was set as the upper limit of continuous heating to prevent animal tissue damage. Take 40 qualified mice and randomly divide them into 4 groups (10 mice in each group), respectively high dose group High (180ug / kg), middle dose group Middle (30ug / kg) and low dose group of Chinese cobra snake venom cardiotoxins cardiotoxins Group Low (5ug / kg), and saline control group control. The method of administration was intragastric administration. The pain threshold of each group after administration for 1h, 2h, 4h, 6h, and 8h was measured. The increase of the pain threshol...

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Abstract

The invention discloses a use of cobra venom cardiotoxins in preparation of a drug for diminishing inflammation, easing pain and resisting arthritis. The drug is a single-component preparation or a compound preparation. 30-3000 micrograms per kilogram of the cobra venom cardiotoxins produce good effects of diminishing inflammation, easing pain and resisting arthritis. The cobra venom cardiotoxins have the advantages of small use amount, safety, oral administration, injection administration, oral and nasal mucosa delivery administration and transdermal delivery administration.

Description

technical field [0001] The invention relates to the application of cardiotoxins of cobra snake venom in the preparation of anti-inflammatory, analgesic and anti-arthritic drugs. Background technique [0002] Snake venom is a complex mixture of components secreted by the snake's venom glands. Fresh venom is egg white-like viscous liquid with a special fishy smell. The venom of different snake species has different colors, and the venom of the Chinese cobra is light yellow. More than 90% of the dry matter of snake venom is protein, which is the main component of its toxicity and biological activity. The components of Chinese cobra venom mainly include cobra venom factor (1%-2%), cardiotoxin (30%-40%, also known as cytotoxin, membrane toxin), neurotoxin (10%) and other proteins. The traditional medicine of the motherland believes that cobra and its toxic components can clear the meridians, dispel rheumatism, and have the effect of strengthening the body. As early as the beg...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/17A61P29/00A61P19/02
Inventor 秦正红陈曹鑫
Owner SUZHOU RENBEN PHARMA
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