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Application of wood frog extracting solution in preparing medicine for treating and preventing cervical cancer

A technology for extracting liquid and cervical cancer, which is applied in the direction of drug combination, liquid delivery, antineoplastic drugs, etc., to achieve the effect of rapid disappearance of clinical symptoms, less toxic and side effects, and less drug resistance

Active Publication Date: 2014-03-26
孟繁清
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

After searching, there is no application of Rana extract in medicines for the treatment and prevention of cervical cancer

Method used

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  • Application of wood frog extracting solution in preparing medicine for treating and preventing cervical cancer
  • Application of wood frog extracting solution in preparing medicine for treating and preventing cervical cancer
  • Application of wood frog extracting solution in preparing medicine for treating and preventing cervical cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Example 1 Preparation of Rana Rana Extract

[0021] Take 15g of dried wood frog (Chinese Rana subspecies Changbai Mountain, purchased from Jilin Pharmacy) and grind it, add 20 times the volume (ml:g) of 9% acetic acid 300ml; ultrasonic extraction, ultrasonic time is 10min, ultrasonic temperature is 18℃ After ultrasonication, filter and centrifuge, the centrifugation temperature is 4°C, the centrifugation time is 16min, and the centrifugation speed is 5500rpm, to obtain the Rana extract.

Embodiment 2

[0022] Example 2 Preparation of Rana Rana Extract Ointment

[0023] Prescription composition (by weight): 24 parts of dried wood frog, 17 parts of paraffin, 45 parts of liquid paraffin, 18 parts of white petrolatum, 34 parts of glyceryl monostearate, 40 parts of 29 parts of Span, 6 parts of emulsifier OP, 3 parts of ethyl hydroxybenzoate, 7 parts of borneol.

[0024] Preparation:

[0025] (1) Preparation of Rana extract: Weigh 20g of dried Rana (Chinese Rana Changbaishan subspecies, purchased from Jilin Pharmacy) and pulverize it, add 25 times the volume (ml:g) of 7% acetic acid and ultrasonically 500ml; ultrasonically Extraction, ultrasonic time is 60min, ultrasonic temperature is 4°C; after ultrasonication, filter and centrifuge, the centrifugation temperature is 4°C, the centrifugation time is 5min, the centrifugation speed is 4000rpm, and the Rana extract is obtained;

[0026] (2) Preparation of the oil phase: Grind and mix paraffin, glycerol monostearate, white petrol...

Embodiment 3

[0028] Example 3 Preparation of Rana Rana Extract Ointment

[0029] Prescription composition (by weight): 36 parts of dried wood frog, 14 parts of paraffin, 39 parts of liquid paraffin, 22 parts of white petrolatum, 37 parts of glyceryl monostearate, 40 parts of 29 parts of spar, 3 parts of emulsifier OP, 4 parts of ethyl hydroxybenzoate, 8 parts of borneol.

[0030] Preparation:

[0031] (1) Preparation of Rana extract: Take 26g of dried Rana (Chinese Rana Changbaishan subspecies, purchased from Jilin Pharmacy) and grind it, add 15 times the volume (ml:g) of 6% acetic acid 390ml; ultrasonically extract, The ultrasonic time was 16 minutes, the ultrasonic temperature was 28°C; after ultrasonication, it was filtered and centrifuged, the centrifugation temperature was 28°C, the centrifugation time was 40 minutes, and the centrifugation speed was 8000rpm to obtain the Rana extract;

[0032] (2) Preparation of the oil phase: Grind and mix paraffin, glycerol monostearate, white ...

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Abstract

The invention relates to an application of a wood frog extracting solution in preparing a medicine for treating and preventing cervical cancer and provides a novel medical application of the wood frog extracting solution. The wood frog extracting solution is used for treating and preventing the cervical cancer caused by SiHa cells and Caski cells by using the inhibition, inflammation-diminishing and antibacterial effects of the wood frog extracting solution; the permeability of bacteria cytomembranes can also be changed and the drug resistance is not easy to cause; a pure biological agent is selected so that the medicine has no toxic effect and no side effect; the medicine can be used for treating both symptoms and root causes and is effective in treatment; clinical symptoms are cured rapidly and the medicine can also have a prevention effect.

Description

technical field [0001] The invention relates to the application of the extract of wood frog in the preparation of medicine for treating and preventing cervical cancer, and an ointment of the extract of wood frog for treating and preventing cervical cancer, belonging to the technical field of medical biopharmaceuticals. Background technique [0002] Cervical cancer is one of the most common gynecological malignancies, and its incidence rate ranks second among female malignancies, second only to breast cancer. There are approximately 470,000 new cases of cervical cancer each year, accounting for 5% of all new cancer cases, and 230,000 deaths from the disease, 80% of which occur in developing countries. Current studies have confirmed that high-risk human papillomavirus (human papilloma virus, HPV) is the most important risk factor for cervical cancer, and its presence can be detected in 99.7% of invasive cervical cancer. More than 200 types of HPV have been identified, of whic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K35/56A61K9/06A61P35/00A61K35/65
Inventor 不公告发明人
Owner 孟繁清
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