Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Anti-inflammatory application of small molecule compound AG-4

A small molecule compound, AG-4 technology, applied in the field of biotechnology and medicine, can solve the problem of anti-inflammatory compounds without CD147, and achieve the inhibition of inflammatory cell chemotaxis, inhibition of monocytes/macrophages and neutrophils Chemotaxis and inhibition of gelatinase secretion

Active Publication Date: 2014-03-26
FOURTH MILITARY MEDICAL UNIVERSITY
View PDF1 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are still no reports of anti-inflammatory compounds targeting CD147 at home and abroad

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Anti-inflammatory application of small molecule compound AG-4
  • Anti-inflammatory application of small molecule compound AG-4
  • Anti-inflammatory application of small molecule compound AG-4

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0026] The present invention will be further described in detail below in conjunction with the accompanying drawings and specific experimental results.

[0027]Previous studies have found that CD147 highly expressed on the surface of monocytes / macrophages and neutrophils in patients with rheumatoid arthritis can promote FLS cells to secrete MMPs, thereby promoting cartilage and bone erosion. CD147 can also promote inflammatory cells to The accumulation of joint lesions aggravates inflammation, thus suggesting that CD147 is involved in the pathogenesis of rheumatoid arthritis. Moreover, in previous studies, the liver cancer monoclonal antibody HAb18 has been successfully used to screen the cDNA library of human liver cancer tissue, and a cDNA fragment encoding HAb18G has been cloned. Query GenBank and found that the open reading frame of the HAb18G gene is highly homologous to the human CD147 molecule. It is a new member of the CD147 family, and the three-dimensional crystal st...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses anti-inflammatory application of a small molecule compound AG-4, and application in preparing anti-inflammatory drug. The small molecule compound AG-4 is screened through a candidate drug screening platform combining structural biology, information biology and biological activity determination. The small molecule compound AG-4 can realize specific binding with CD147 protein to inhibit inflammatory cell chemotaxis and secretion of chemotaxis; the invention is also suitable for preparing medicines for treating CD147 protein high expression related diseases (such as rheumatoid arthritis).

Description

technical field [0001] The invention belongs to the fields of biotechnology and medicine, and in particular relates to the anti-inflammatory application of small molecular compound AG-4. Background technique [0002] Rheumatoid arthritis (RA) is the most common chronic inflammatory joint disease with a global incidence of 1%. There are more than 5 million RA patients in my country. The disability rate of RA patients is high. Within the first 2 years of onset, about 75% of patients have joint damage, and 80% of patients suffer from joint deformation and disability after 20 years. Some patients' disease progresses rapidly and even leads to death. Therefore, the treatment of RA has always been the focus of medical attention. At present, the pathogenesis of RA is not clear, thus limiting the progress of treatment. [0003] CD147 molecule is a widely expressed glycoprotein and a member of the immunoglobulin superfamily. CD147 is widely expressed in various types of cells, espe...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4035A61P29/00A61P19/02
Inventor 汪莉朱平王聪华付之光李郁蒋建利陈志南
Owner FOURTH MILITARY MEDICAL UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com