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Merariveron sustained-release tablet and preparation method thereof

A technology of mirabegron and sustained-release tablets, which is applied in the field of medicine to achieve the effects of convenient taking, increased patient compliance, and increased drug efficacy

Inactive Publication Date: 2014-03-26
BEIJING RUNDEKANG MEDICAL TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no imported drugs or domestic generic drugs on the market

Method used

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  • Merariveron sustained-release tablet and preparation method thereof
  • Merariveron sustained-release tablet and preparation method thereof
  • Merariveron sustained-release tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025]

[0026] Preparation:

[0027] (1) pass the raw and auxiliary materials through an 80-mesh sieve, and set aside;

[0028] (2) Weigh the DBT and Mirabegron of the prescription amount, mix the two evenly by the method of increasing and mixing in equal amounts, weigh HPMC E15, polyethylene glycol, microcrystalline cellulose and add and mix well 3 minutes;

[0029] (3) Add an appropriate amount of ethanol to make a soft material, pass through a 24-mesh sieve to granulate, and dry in a 60-degree oven for 1 hour;

[0030] (4) Pass through a 26-mesh sieve for granulation, add an appropriate amount of lubricant, mix evenly, and compress into tablets.

Embodiment 2

[0032]

[0033] Preparation:

[0034] (1) pass the raw and auxiliary materials through an 80-mesh sieve, and set aside;

[0035] (2) Take by weighing the DBT and Mirabegron of the prescription amount, mix the two by the method of adding and mixing in equal amounts, weigh HPMC K100LV, add polyethylene glycol and microcrystalline cellulose and mix well 3 minutes;

[0036] (3) Add an appropriate amount of ethanol to make a soft material, pass through a 24-mesh sieve to granulate, and dry in a 60-degree oven for 1 hour;

[0037] (4) Pass through a 26-mesh sieve for granulation, add an appropriate amount of lubricant, mix evenly, and compress into tablets.

Embodiment 3

[0039]

[0040] Preparation:

[0041] (1) pass the raw and auxiliary materials through an 80-mesh sieve, and set aside;

[0042] (2) Take by weighing DTBH and Mirabegron in the prescribed amount, mix the two evenly by adding and mixing in equal amounts, weigh HPMC K4M, add polyethylene glycol and microcrystalline cellulose and mix evenly 3 minutes;

[0043] (3) Add an appropriate amount of ethanol to make a soft material, pass through a 24-mesh sieve to granulate, and dry in a 60-degree oven for 1 hour;

[0044] (4) Pass through a 26-mesh sieve for granulation, add an appropriate amount of lubricant, mix evenly, and compress into tablets.

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Abstract

The invention discloses a merariveron sustained-release tablet and a preparation method thereof. The merariveron sustained-release tablet is prepared from the following raw materials in percentage by weight: 5- 20% of merariveron, 10-70% of a skeleton material, 1- 5% of an antioxidant, 0.1-5% of a lubricant, 0-70% of a filler and a proper amount of an adhesive. The merariveron sustained-release tablet adopts a film coating, and thus the stability of the merariveron sustained-release tablet is improved. The sustained-release materials in the merariveron sustained-release tablet reduce influences, on release, of different PH valves. The influences, on the absorption of the merariveron sustained-release tablet, of food, are reduced, long-time stable effective drug concentration is kept, and thus the curative effect of the merariveron sustained-release tablet is improved. A patient only needs to take the merariveron sustained-release tablet once a day; the compliance of the patient is improved.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a Mirabegron sustained-release tablet and a preparation method thereof. Background technique [0002] In daily life, many people will suffer from such troubles: [0003] Urinary urgency: the urge to urinate comes suddenly and cannot be delayed or tolerated; [0004] Frequent urination: Always need to urinate, more than 8 times a day; [0005] Nocturia: Waking up 2 or more times a night to urinate; [0006] Urge urinary incontinence: Uncontrollable leakage of urine onto clothing following an urgency to urinate. [0007] In fact, it is very likely that this is overactive bladder. The International Continence Society (International Continence Society) believes that: Overactive Bladder (OAB) is a syndrome characterized by symptoms of urinary urgency, often accompanied by urinary symptoms, with or without urge urinary incontinence ; its pathology is not fully understood, it is k...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/22A61K31/426A61K47/38A61K47/32A61K47/34A61K47/36A61K47/14A61P13/10A61P13/00
Inventor 不公告发明人
Owner BEIJING RUNDEKANG MEDICAL TECH CO LTD
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