Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of targeted anticancer molecule gefitinib phthalocyanine conjugate and its preparation and application

A conjugated and targeted technology, which is applied in the direction of active ingredients of silicon compounds, medical preparations containing active ingredients, compounds of elements of Group 4/14 of the periodic table, etc., can solve difficult synthesis, difficult separation, and tumor tissue Targeting is not very ideal, etc.

Active Publication Date: 2015-09-09
FUZHOU UNIV
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the existing substituted phthalocyanine metal complexes have problems such as difficult synthesis, many side reactions, and difficult separation.
At the same time, there is an important problem that the targeting of phthalocyanine to tumor tissue is not ideal, so the research on the targeting of photosensitizers has become a hot research topic now.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Example 1 (M=Zn, n=2, α-position monosubstituted)

[0043] 1) Add 12.0g of the compound to a 350ml round bottom flask equipped with a temperature-controlled magnetic stirrer 1 , 3.8g p-toluenesulfonyl chloride and 40mlCH 2 Cl 2 , after fully stirring and dissolving, add 10g triethylamine, react at room temperature for 10 hours, after the reaction, extract three times with 200ml saturated sodium chloride solution and 200ml 1mol / L hydrochloric acid solution respectively, collect the organic layer and dry it with anhydrous magnesium sulfate , filtered and then evaporated to remove CH 2 Cl 2 , with CH at a volume ratio of 30:1 2 Cl 2 with CH 3 The mixed solvent of OH is used as a developing agent to pass through a silica gel column to obtain compound 1a;

[0044] 2) Add 3g of the compound sequentially into a 150ml double-neck bottle equipped with nitrogen ventilation equipment 1a , 0.8gNaN 3 , 15ml of acetonitrile was used as the reaction solvent, and refluxed for ...

Embodiment 2

[0056] Example 2 (M=Zn, n=2, β-position monosubstituted)

[0057] 1) Add 12.0g of the compound to a 350ml round bottom flask equipped with a temperature-controlled magnetic stirrer 1 , 3.8g p-toluenesulfonyl chloride and 40mlCH 2 Cl 2 , after fully stirring and dissolving, add 10g of triethylamine, react at room temperature for 10 hours, after the reaction, extract three times with 200ml of 1mol / L hydrochloric acid solution and 200ml of saturated sodium chloride solution, collect the organic layer and dry it with anhydrous magnesium sulfate , filtered and then evaporated to remove CH 2 Cl 2 , to CH 2 Cl 2 with CH 3 A mixed solvent with a volume ratio of OH of 30:1 is used as a developing agent to pass through a silica gel column to obtain compound 1a;

[0058] 2) Add 3g of the compound sequentially into a 150ml double-neck bottle equipped with nitrogen ventilation equipment 1a , 0.8gNaN 3 , 15ml of acetonitrile was used as the reaction solvent, and refluxed for 24h. A...

Embodiment 3

[0065] Example 3 (M=Al, n=2, α single substitution)

[0066] 1) Add 12.0g of the compound to a 350ml round bottom flask equipped with a temperature-controlled magnetic stirrer 1 , 3.8g p-toluenesulfonyl chloride and 40mlCH 2 Cl 2 , after fully stirring and dissolving, add 10g of triethylamine, react at room temperature for 10 hours, after the reaction, extract three times with 200ml of 1mol / L hydrochloric acid solution and 200ml of saturated sodium chloride solution, collect the organic layer and dry it with anhydrous magnesium sulfate , filtered and then evaporated to remove CH 2 Cl 2 , to CH 2 Cl 2 with CH 3 A mixed solvent with a volume ratio of OH of 30:1 is used as a developing agent to pass through a silica gel column to obtain compound 1a;

[0067] 2) Add 3g of the compound sequentially into a 150ml double-neck bottle equipped with nitrogen ventilation equipment 1a , 0.8gNaN 3 , 15ml of acetonitrile was used as the reaction solvent, and refluxed for 24h. After ...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a targeted anti-cancer molecule gefitinib phthalocyanine conjugate, and a preparation method and application thereof. The molecular formula of the gefitinib phthalocyanine conjugate is C56+2nH42+4nO5+nClFN12Zn (n=2-8). Gefitinib with an alkoxyl long chain is introduced into the periphery of a metal phthalocyanine large ring, so the amphipathicity and the biocompatibility can be improved, and the targeting property of a photosensitizer is enhanced. The gefitinib phthalocyanine conjugate is difficult to aggregate, so the cellular uptake ratio is increased and the activity of the photosensitizer in photodynamic therapy is also enhanced. The compound has single structure, is not provided with an isomer, and is easy to purify. A synthesis method is simple, little in side reaction, high in yield, easily available in raw materials, low in cost and favorable for industrialized production.

Description

technical field [0001] The invention belongs to the field of synthesis of organic and metal coordination compounds, and relates to a targeted anticancer molecule gefitinib phthalocyanine conjugate and its preparation method and application. Background technique [0002] Phthalocyanine compound is a sixteen-membered ring large π system, which has good light, heat and chemical stability, excellent optical, magnetic and electrical properties, so phthalocyanine complexes are widely used in many fields, such as biosensors, non-toxic Linear optical materials, dye-sensitized photovoltaic products, semiconductor materials, oxidation or reduction catalysts, etc. In addition, phthalocyanines are the most promising class of photosensitizers in photodynamic therapy due to their strong absorption in the near-infrared region and the ability to generate cytotoxic reactive oxygen species. [0003] The diversity and structural "modification" of phthalocyanine compounds provide the possibili...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07D487/22A61K41/00A61K31/5377A61P35/00
CPCA61K31/5377A61K31/695A61K41/0071C07D487/22C07F7/10
Inventor 薛金萍周晓琴黄琪张明俊
Owner FUZHOU UNIV
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com