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Wettability andrographis paniculata powder and preparation method thereof

A technology of andrographis paniculata and wetness is applied in the field of wettable andrographis paniculata and its preparation field, and can solve the problems of difficulty in mixing evenly, not suitable for large-scale cultivation, time-consuming and labor-intensive, and the like.

Inactive Publication Date: 2014-03-05
CHENGDU QIANKUN VETERINARY PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Andrographis paniculata unilateral dosage forms available in veterinary clinic include Churographis paniculata tablets, Andrographis paniculata powder, and Andrographis paniculata injection. Feed administration, feed administration requires that the drug and feed be mixed evenly, but it is difficult to mix evenly in actual operation, which may easily cause excessive drug intake, poisoning or too little drug intake without curative effect; and feed administration is easy to change the feed Flavor, causing animal refueling stress, resulting in a decrease in animal feed intake and no therapeutic effect; injection formulations have good therapeutic effects, but are time-consuming and laborious, and are not suitable for large-scale farming

Method used

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  • Wettability andrographis paniculata powder and preparation method thereof
  • Wettability andrographis paniculata powder and preparation method thereof
  • Wettability andrographis paniculata powder and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0209] Example 1 Formula screening of wettable andrographis powder

[0210] The screening formula is shown in formula 1 to formula 6 in Table 1:

[0211] Table 1 The optimal formula of wettable andrographis powder

[0212]

[0213] Weigh the raw materials of formula 1 to formula 6 in Table 1, respectively, and take Andrographis paniculata to crush into 625 mesh fine powder for later use;

[0214] Mix povidone K-30 and tannic acid, 1.2~26L of absolute ethanol, add butyl anisole, stir to dissolve, add the fine powder prepared above, mix well, ventilate and dry at 50℃, and then add Spartame, phosphatidic acid, and sodium carboxymethyl cellulose are mixed and crushed to obtain wettable andrographis powder prepared from formula 1 to formula 6.

[0215] The wettable andrographis powder prepared from formula 1 to formula 6 were evaluated for dispersion quality, sedimentation volume ratio, and palatability quality.

[0216] Dispersion quality evaluation: Take 1g of wettable andrographis powder ...

Embodiment 2

[0232] Example 2 Preparation of wettable andrographis powder

[0233] formula:

[0234]

[0235] Take Andrographis paniculata and crush it into 700 mesh fine powder for later use;

[0236] Take povidone K-30, add 5L of absolute ethanol and mix, stir to dissolve, add the fine powder prepared above, mix well, ventilate and dry at 35°C, add sodium carboxymethyl cellulose, mix and smash to get The wettable andrographis powder of the present invention.

Embodiment 3

[0237] Example 3 Preparation of wettable andrographis powder

[0238] formula:

[0239]

[0240] Take Andrographis paniculata and crush it into 1000 mesh fine powder for later use;

[0241] Take povidone K-30, tannic acid, and 19.4L of absolute ethanol and mix, stir to dissolve, add the above to make a fine powder, mix well, dry at 40℃ in ventilation, add aspartame, phosphatidic acid, carboxymethyl The sodium cellulose is mixed and pulverized to obtain the wettable andrographis powder of the present invention.

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PUM

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Abstract

The invention relates to the technical field of veterinary medicine preparation and particularly relates to wettability andrographis paniculata powder and a preparation method thereof. The wettability andrographis paniculata powder which can easily and uniformly disperse in water and is beneficial to administration with water is prepared by adding a suspending agent and a dispersing agent on the basis of an andrographis paniculata effective component through the reasonable medicine proportioning. The wettability andrographis paniculata powder provided by the invention is convenient to use and has a good treatment effect. The survey tests on the curative effect on animals show that the treatment effect of the wettability andrographis paniculata powder on swine pneumonia is obviously superior to that of tilmicosin premix (P is less than 0.05), and the treatment effect of the wettability andrographis paniculata powder on broiler chicken pullorum disease is obviously superior to that of commercially available andrographis paniculata powder (P is less than 0.05). The invention also provides a preparation method of the wettability andrographis paniculata powder. The preparation method is simple in process, low in production cost and suitable for industrial mass production.

Description

Technical field [0001] The invention relates to the technical field of veterinary medicine preparation, in particular to a wettable andrographis powder and a preparation method thereof. Background technique [0002] Andrographis paniculata is also known as spring lotus and autumn willow, bliss, olive core lotus, bitter grass, golden vanilla, golden ear hook, Indian grass, bitter grass, etc. It is a plant of the genus Acacia and andrographis, bitter, cold in nature, home to heart, lungs , Large intestine, bladder meridian, is a commonly used Chinese herbal medicine with a wide source and few side effects. Andrographis paniculata has the functions of clearing away heat, detoxifying, cooling blood and reducing swelling. It can be used with mint, chrysanthemum and platycodon to clear the throat and throat; when used with plaster, anemarrhena, honeysuckle, and forsythia, it can clear the lungs and purify fire and detoxify; Use Daqingye to cool the blood and detoxify and reduce swelli...

Claims

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Application Information

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IPC IPC(8): A61K36/19A61P11/00A61P1/12A61P31/04
Inventor 丁晓刚房春林李犹平徐莎
Owner CHENGDU QIANKUN VETERINARY PHARMA
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