Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Application of spiraea alpine extract in antiviral drug preparation

A technology of Alpine meadowsweet and antiviral drug, applied in the field of biomedicine, can solve the problems such as no reports on research on antibacterial and antiviral effects of Alpine meadowsweet, and achieve the effects of preventing virus invasion and protecting cells

Inactive Publication Date: 2014-03-05
黄瑞雪
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The above-mentioned literature and patents, etc., have not yet seen reports on the antibacterial and antiviral effects of Spiraea alpine or Spiraea alpine extracts

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Application of spiraea alpine extract in antiviral drug preparation
  • Application of spiraea alpine extract in antiviral drug preparation
  • Application of spiraea alpine extract in antiviral drug preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1: the preparation of alpine Spiraea extract

[0036] (1) Spiraea alpine 18kg, extracted with 95% ethanol, filtered to obtain extract A and dregs A, extract A was concentrated to an alcohol-free paste, added distilled water, steam distilled, and collected the distillate , adding 4% of distillate weight β-cyclodextrin clathrate, cold storage, filtration, low-temperature drying, to obtain the clathrate of the volatile oil of Spiraea alpine;

[0037](2) Use the dregs A obtained in step (1) with 60% ethanol solution as a solvent, the extraction temperature is 80°C, the number of extractions is 2 times, the extraction time is 2 hours each time, and the amount of solvent used each time is Meadowsweet alpine 12 times the weight; filter to obtain extract B and drug residue B; extract B, recover ethanol, concentrate to relative density d=1.13, filter to obtain drug C;

[0038] (3) Pass the drug solution C obtained in step (2) through ADS-3 macroporous adsorption resi...

Embodiment 2

[0041] Embodiment 2: the preparation of alpine Spiraea extract

[0042] (1) 15kg of Spiraea alpine, extract with 95% ethanol, filter to obtain extract A and dregs A, extract A is concentrated to an alcohol-free paste, add distilled water, carry out steam distillation, and collect the distillate , adding 4% of distillate weight β-cyclodextrin clathrate, cold storage, filtration, low-temperature drying, to obtain the clathrate of the volatile oil of Spiraea alpine;

[0043] (2) Use the dregs A obtained in step (1) with 30% ethanol solution as a solvent, the extraction temperature is 95°C, the number of extractions is 1 time, and the extraction time is 4 hours each time, and the amount of solvent used each time is Spiraea alpine 15 times the weight; filter to obtain extract B and drug residue B; extract B, recover ethanol, concentrate to relative density d=1.18, filter to obtain drug C;

[0044] (3) Pass the medicinal liquid C obtained in step (2) through HP20 macroporous adsorp...

Embodiment 3

[0047] Example 3: Preparation of Spiraea Alpine Extract and Monomer Compounds

[0048] (1) 20kg of Spiraea alpine, extract with 95% ethanol, filter to obtain extract A and dregs A, concentrate extract A to a clear paste without alcohol, add distilled water, carry out steam distillation, and collect the distillate , adding 4% of distillate weight β-cyclodextrin clathrate, cold storage, filtration, low-temperature drying, to obtain the clathrate of the volatile oil of Spiraea alpine;

[0049] (2) Use the dregs A obtained in step (1) with 75% ethanol solution as a solvent, the extraction temperature is 50°C, the number of extractions is 3 times, and the extraction time is 1 hour each time, and the amount of solvent used each time is Meadowsweet alpine 6 times the weight; filter to obtain extract B and medicinal residue B; extract B, recover ethanol, concentrate to relative density d=1.10, filter to obtain medicinal liquid C;

[0050] (3) Pass the drug solution C obtained in step...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a novel application of spiraea alpine extract, and the novel application is the application of spiraea alpine extract in the antiviral drug preparation. The spiraea alpine extract is prepared by the following steps: taking spiraea alpine as a raw material, extracting volatile oil from the spiraea alpine, then extracting the volatile oil with ethanol with a concentration of 30% to 75%, and finally purifying the extract with a macroporous absorption resin and neutral alumina so as to obtain the finished product. The spiraea alpine extract provided by the invention has a very important meaning for antivirus drug preparation.

Description

technical field [0001] The invention belongs to the field of biomedicine, and relates to the application of an extract of traditional Chinese medicinal materials in the preparation of antiviral drugs, in particular to the application of the extract of Spiraea alpine in the preparation of antiviral drugs. Background technique [0002] The increasing bacterial resistance caused by the extensive use of antibiotics has become one of the problems of common concern all over the world. Especially the drug resistance rate of Staphylococcus aureus has reached more than 90%. Herpes simplex virus type II mainly causes skin and mucous membrane infection in the genital area. The virus enters the body through the respiratory tract, oral cavity, genital mucosa and damaged skin, and resides in the normal mucosa, blood, saliva and sensory ganglion cells of the human body. When the body's resistance declines, such as fever, gastrointestinal disorders, menstruation, pregnancy, focal infectio...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K36/03A61P31/12A61P31/22
Inventor 孔倩倩
Owner 黄瑞雪
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com