Novel preparation process of compound sophora flavescens salicylic acid medicinal powder

A technology of salicylic acid powder and new process is applied in the field of new technology for preparing compound Sophora flavescens salicylic acid powder. Pharmacological effects, the effect of saving medicinal materials

Inactive Publication Date: 2014-02-26
广东恒诚制药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Diffusion requires a concentration difference between the inside and outside of the cell. When the concentration difference between the inside and outside of the cell is small or balanced, the release rate of the active ingredient will be very slow or even stop. to effective therapeutic concentrations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] For the compound flavescens salicylic acid powder preparation, the weight ratio of raw materials is as follows:

[0016] Sophora flavescens 110 kg, salicylic acid 90 kg, benzoic acid 60 kg, boric acid 230 kg, talcum powder 50 kg,

[0017] The preparation process includes the following steps:

[0018] (1) Wash, dry, and crush 110kg of Sophora flavescens into superfine powder (with a particle size below 10 μm), and the proportion of micro particles with a particle size of 5-10 μm is 50%;

[0019] (2) Put 90kg of salicylic acid, 60kg of benzoic acid, 230kg of boric acid, and 50kg of talcum powder into a two-dimensional mixer for pre-mixing, and put them into a multifunctional pulverizer to pulverize;

[0020] (3) Mix it evenly with Sophora flavescens superfine powder in a two-dimensional mixer, put the uniformly mixed medicinal powder in a powder dispensing machine for packaging, and pack it into a box.

Embodiment 2

[0022] For the compound flavescens salicylic acid powder preparation, the weight ratio of raw materials is as follows:

[0023] Sophora flavescens 130kg, salicylic acid 110kg, benzoic acid 80kg, boric acid 250kg, talcum powder 70kg,

[0024] The preparation process includes the following steps:

[0025] (1) Wash, dry and crush 130kg of Sophora flavescens into ultra-fine powder (with a particle size of less than 10 μm), and the proportion of fine particles with a particle size of 5-10 μm is 50%;

[0026] (2) Put 110kg of salicylic acid, 80kg of benzoic acid, 250kg of boric acid, and 70kg of talcum powder into a two-dimensional mixer for premixing, and put them into a multifunctional pulverizer to pulverize;

[0027] (3) Mix it evenly with Sophora flavescens superfine powder in a two-dimensional mixer, put the uniformly mixed medicinal powder in a powder dispensing machine for packaging, and pack it into a box.

[0028] clinical information:

[0029] One, general data: this ...

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Abstract

The invention discloses a novel preparation process of compound sophora flavescens salicylic acid medicinal powder for treating tinea of feet and hands and belongs to the technical field of traditional Chinese medicine preparations. The preparation process includes: cleaning 110-130kg of sophora flavescens, drying, and pulverizing into ultra-fine powder (with the particle size of below 10 micrometers); premixing 90-110kg of salicylic acid, 60-80kg of benzoic acid, 230-250kg of boric acid and 50-70kg talcum powder in a two-dimensional mixing machine, and pulverizing the same in a multifunction pulverizer; evenly mixing the obtained products with the ultra-fine sophora flavescens powder in the two-dimensional mixing machine, split charging the evenly mixed medicinal powder with a split charging machine, and packing. The compound sophora flavescens salicylic acid medicinal powder prepared by the process stays longer at the affected parts, absorption is sufficient, absorption amount is increased, and medicinal effectiveness is guaranteed.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a new preparation process of compound flavescens salicylic acid powder for treating tinea pedis and tinea pedis. Background technique [0002] Compound flavescens salicylic acid powder is an antifungal drug for external use in dermatology. It is now included in the National Standard for Chemical Drugs (Volume 7) WS-10001-(HD-0630)-2002. The prescription is composed of Sophora flavescens, salicylic acid, benzoic acid, and boric acid. It is a compound preparation of Chinese and Western medicines and is clinically used for tinea pedis and tinea pedis. This product is a new type of allylamine topical antifungal drug, in which Sophora flavescens can inhibit the growth of various skin fungi, such as Trichophyton rubrum, etc.; benzoic acid is a disinfectant and antiseptic, which can inhibit common bacteria and fungi; water Salicylic acid has antifungal, antipruritic and kerat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61J3/02A61K36/489A61K9/14A61P31/10A61P17/00
Inventor 汤小燕郑文彤张志涛邓枚陈雨符正南
Owner 广东恒诚制药股份有限公司
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