A kind of hand ginseng Shenbao pharmaceutical composition and its preparation method and application

The technology of hand ginseng kidney treasure and composition is applied in the field of medicinal composition of hand ginseng kidney treasure and its preparation, which can solve the problems of unstable quality, inability to adapt, slow onset of effect, etc., achieve stable quality control, reduce dosage, Curative effect

Active Publication Date: 2015-11-18
JINKE TIBETAN MEDICINE QINGHAI PROV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the current standard and the above-mentioned two patent materials, the three hand ginseng kidney treasure preparations are only the fine powder or extract obtained by simply crushing or decocting the four medicinal materials, and adding Cordyceps fine powder. The process is simple, there are too many impurities, Large dosage, inaccurate medicinal ingredients, unstable quality, slow onset of action, difficult to control microorganisms, etc., cannot meet the clinical needs of modern pharmacy

Method used

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  • A kind of hand ginseng Shenbao pharmaceutical composition and its preparation method and application
  • A kind of hand ginseng Shenbao pharmaceutical composition and its preparation method and application
  • A kind of hand ginseng Shenbao pharmaceutical composition and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0039] Experimental example 1, macroporous resin purification process experiment of total flavonoids

[0040] The preparation of Rhododendron japonica extract concentrate: take 32 parts by weight of Rhododendron japonica, heat and boil with 70% ethanol by volume to extract twice, add 8 times the total weight of medicinal materials for the first time, extract for 2 hours, add 70% ethanol for the second time 8 times the total weight of the medicinal materials, extract for 1 hour; combine the extracts, recover ethanol under reduced pressure until there is no alcohol smell, and obtain the alcohol extraction concentrate, add petroleum ether for extraction 3 times, add 1 times the volume of the concentrate each time, The petroleum ether solution was discarded, and the aqueous solution was concentrated until every 4ml of the medicinal solution was equivalent to 1g of the medicinal material, and the concentrated solution of Rhododendron was extracted.

[0041] Determination method of ...

experiment example 2

[0059] Experimental example 2, total polysaccharide preparation process screening

[0060] The present invention prepares the total polysaccharides of effective parts by water extraction and alcohol precipitation method, and screens the alcohol precipitation process according to the yield and content of the total polysaccharides.

[0061] Weigh 100g of hand ginseng, 100g of sealwort, 62.4g of asparagus according to the proportion of the prescription, add water and reflux to extract twice, add 10 times the amount for the first time, add 8 times the amount for the second time, extract for 2 hours each time, combine the extracts, and decompress Concentrate to a density of 1.25 (40 ℃) clear paste 208g. Take two portions of thick paste, each 100g, and carry out one alcohol precipitation and two alcohol precipitation experiments respectively.

[0062] One-time alcohol precipitation: 80% alcohol concentration, 4°C, alcohol precipitation for 24 hours, filter, dissolve the precipitate...

experiment example 3

[0068] Experimental Example 3: Clinical Observation on the Treatment of Kidney-Yang Deficiency Syndrome

[0069] 1 clinical data

[0070] 1.1 Diagnostic criteria:

[0071] (1) TCM diagnostic criteria for kidney-yang deficiency syndrome, symptoms include: ①Sore waist and knees; ②Aversion to cold and cold limbs; ③Loss of libido. Secondary symptoms: ① lethargy; ② nocturnal frequent urination; ③ lower extremity edema; ④ shortness of breath when moving; Diagnosis can be made by seeing 2 or more main symptoms or 1 main symptom plus 2 secondary symptoms. (Zheng Xiaoyu. Guiding Principles for Clinical Research of New Drugs of Traditional Chinese Medicine (Trial)[M]. Beijing: China Medical Science and Technology Press, 2002:156-162.)

[0072] 1.2 Inclusion criteria:

[0073] (1) Meet the diagnostic criteria of TCM kidney-yang deficiency syndrome.

[0074] (2) Aged from 18 to 65 years old.

[0075] (3) Not taking similar drugs within 2 weeks.

[0076] (4) The patient agrees and s...

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Abstract

The invention relates to a medicinal composition of Shoushen Shenbao, a preparation method and application thereof. The Shoushen Shenbao medicinal composition comprises 2-5 parts by weight of total flavonoids, 55-80 parts by weight of total polysaccharides, 5-7 parts by weight of cordyceps powder, the total flavonoids content exceeds 60%, the yield exceeds 40%, and the total polysaccharide content More than 70%, the yield is more than 12%. The Shoushen Shenbao pharmaceutical composition of the present invention further removes impurities, clarifies the effective ingredients, and is convenient for inspection. It has been clinically proven that the Shoushen Shenbao pharmaceutical composition of the present invention has a significant curative effect in the treatment of kidney-yang deficiency syndrome, and the superior to the original preparation.

Description

technical field [0001] The present invention relates to a medicine composition and its preparation method and application, in particular to a hand ginseng Shenbao pharmaceutical composition and its preparation method and application. Background technique [0002] Shoushen Shenbao Capsules are recorded in the national drug standard part of the local standards of Chinese patent medicines, standard number: WS-10550 (ZD-0550)-2002 (referred to as "the current standard"), the prescription of Shoushen Shenbao Capsules is as follows: Shoushen Shenbao Capsules are as follows: Polygonatum 100g, Radix Asparagus 62.4g, Rhododendron lanceolata 32g, Cordyceps sinensis 6.3g; the preparation method is: crush the above-mentioned five medicinal materials into fine powder, mix well, put them into capsules, and make 1000 capsules. The medicine has the effects of warming the kidney and tonifying yin, replenishing the essence and tonifying the marrow, and is used for insufficiency of kidney yang...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/898A61P15/10A61P13/12A61P1/08
Inventor 李晗王京凯赵丽丽姬涛魏永义
Owner JINKE TIBETAN MEDICINE QINGHAI PROV
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