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A kind of method using succinic acid fermented liquid to prepare tetrahydrofuran

A technology of tetrahydrofuran and succinic acid, applied in the direction of organic chemistry, can solve the problems of reducing product yield, achieve the effect of reducing cost and simplifying the sodium removal process

Active Publication Date: 2015-08-26
师恩(厦门)生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In the traditional fermentation broth post-treatment process, most of them have a set of activated carbon adsorption decolorization system, but activated carbon inevitably adsorbs organic acid products during the adsorption decolorization process, which greatly reduces the product yield.

Method used

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  • A kind of method using succinic acid fermented liquid to prepare tetrahydrofuran

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Embodiment 1

[0034] The fermentation broth was prepared with a target volume of 2400L. The nutrient base composition of the fermentation broth: 36g of potassium dihydrogen phosphate, 12g of sodium hydrogen phosphate, 1g of magnesium chloride, 1g of calcium chloride, 24kg of yeast extract, 24kg of corn steep liquor, 201.4kg of sodium carbonate, 336kg of glucose (85%), and the rest is water. Actinobacillus succinogenes CGMCC1593 was used as the synthetic strain of succinic acid. After actual sterilization, cooling, and inoculation, the fermentation temperature was 37-38°C, the stirring speed was 60rpm, and the fermentation time was 48 hours. The acid content is 95g / L.

[0035] The above-mentioned fermented liquid is separated from bacteria through a centrifuge, the centrifuge is disc type, the rotating speed is 4000rpm, the obtained clear and transparent liquid is 2300L, and the content of succinic acid is 90g / L.

[0036]The clarified fermentation broth is placed in a bipolar membra...

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Abstract

The invention discloses a method for preparing tetrahydrofuran by using succinic acid fermentation broth, belonging to the technical field of biochemical engineering. According to the method, tetrahydrofuran is prepared by directly esterifying, hydrogenating and refining fermentation liquid containing butanedioic acid, so as to avoid the technological process of performing the consequent reaction after the butanedioic acid solid is obtained at high cost; bipolar membrane electrodialysis is used for removing sodium ions from butanedioic acid fermentation liquid which is subjected to filtering treatment, so as to reduce the influence on the service life of an esterified catalyst in the follow-up working section; the pigment in the fermentation liquid can be removed through rectification so as to prevent the activated carbon from decoloring. The method has the beneficial effects of avoiding the obtainment of the butanedioic acid solid, reducing a great amount of steam consumed in the process, and greatly lowering the cost; a sodium removal technology can be simplified, and the introduction of impurity negative ions can be avoided; the pigment can be removed through adopting a rectification and separation method while the refinement of tetrahydrofuran is realized.

Description

technical field [0001] The invention relates to a method for preparing tetrahydrofuran from the fermented liquid prepared from succinic acid by a fermentation method. In particular, it does not need to undergo decolorization of the fermented liquid, and does not need to obtain solid succinic acid. Tetrahydrofuran is directly prepared from the fermented liquid, and realized in the process of rectification. The invention relates to a process for removing pigment in fermentation liquid during the process, and belongs to the technical field of biochemical industry. Background technique [0002] Use succinic acid prepared by fermentation to produce tetrahydrofuran. The traditional process idea is to first obtain solid succinic acid from the fermentation broth, then esterify with methanol to produce dimethyl succinate, and finally the esterified product is hydrogenated. Tetrahydrofuran and butanediol are obtained. [0003] In order to obtain solid succinic acid in the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D307/08
CPCC07D307/08
Inventor 杨啸坤林吉吕涛
Owner 师恩(厦门)生物科技有限公司
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