Experiment method based on pH value-sensitive magnetization transfer on 1.5T magnetic resonance imaging

Abstract

The invention discloses an experiment method based on pH value-sensitive magnetization transfer on 1.5T magnetic resonance imaging. The method includes the following steps that two groups of pH value test tube models are prepared, and an agarose-creatine model is arranged in each test tube; scanning is carried out on a clinical 1.5T magnetic resonance scanner, the coil adopted by scanning is an eight-channel transmitter / receiver coil, and the offset frequency of a radio-frequency pulse can be set as negative 121Hz, 121Hz and 224Hz by modifying sequential source codes; and at the offset frequency of 224Hz, the high-quality magnetization transfer imaging of the two groups of pH value test tube models can be obtained. By utilizing the magnetization transfer technology, optimizing sequential parameters and choosing offset frequency, the experiment method can obtain pH value-sensitive magnetization transfer imaging on the clinical 1.5T magnetic resonance scanner, provides an experimental basis for the clinical research of pH value-sensitive magnetization transfer imaging, and is significant in characterizing ischemic tissue-damaged regions and directing the treatment of strokes and the diagnosis of tumors.

Description

technical field [0001] The invention belongs to the technical field of nuclear magnetic resonance, and in particular relates to an experimental method based on pH value-sensitive magnetization transfer on 1.5T magnetic resonance imaging. Background technique [0002] The magnetization effect phenomenon is commonly seen in muscle and brain tissue, and its main principle is to use biased radio frequency pulses to saturate the hydrogen protons on macromolecules or water molecules bound to macromolecules, which will chemically exchange with hydrogen protons of free water, As a result, the magnetization transfer effect is generated, which indirectly leads to the decrease of the magnetic resonance water signal intensity; [0003] In recent years, the chemical exchange saturation transfer (Chemical Exchange Saturation Transfer, CEST) technology and the amide proton transfer (Amide Proton Transfer, APT) technology based on the theory of magnetization transfer technology and chemical...

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Problems solved by technology

[0006] The purpose of the present invention is to provide an experimental method based on pH-sensitive magnetization transfer on 1.5T magnetic resonance imaging, aiming to solve the problem of long acquisition time and large duty cycle of CEST imaging in existing imaging methods, which lead to special The increase of absorption rate has higher requirements on magnetic resonance hardware, which greatly limits the clinical application of CEST imaging to the human body

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