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Method for extracting parthenolide from plant raw material

A parthenolide, plant raw material technology, applied in bulk chemical production, organic chemistry and other directions, can solve the problems of waste of organic solvents, large environmental pollution, high impurity content, and achieve low cost, simple extraction process and high efficiency. Effect

Active Publication Date: 2014-01-22
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0009] Chinese patents CN102241684A and CN102863452A disclose the solvent extraction method of parthenolide, which belongs to the traditional steaming and decocting method, with high content of impurities (wax), and cumbersome operation, waste of a large amount of organic solvent, great environmental pollution, and high production cost

Method used

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  • Method for extracting parthenolide from plant raw material
  • Method for extracting parthenolide from plant raw material

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Experimental program
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Effect test

Embodiment 1

[0029] 1) First, the Xiangzi Michelia leaves are naturally dried, crushed, and sifted through a 10-mesh sieve to obtain Xiangzi Michelia leaves powder;

[0030] 2) Set the temperature of the extraction tank to 35°C, the temperature of the separation tank I to 50°C, and the temperature of the separation tank II to 40°C;

[0031] 3) Put the barrel containing 500g of fragrant seeds and smiley leaf powder into the extraction tank and add 500mL of 90% methanol;

[0032] 4) Start the carbon dioxide circulation system, adjust the pressure of the extraction cylinder to 15MPa, the pressure of the separation cylinder I to 10MPa, and the pressure of the separation cylinder II to 6MPa. Adjust the mass flow of carbon dioxide corresponding to each kilogram of raw material (Fragrant Seed and Smile Leaf Powder) to 0.5kg / h. When the temperature and pressure reach the set value, start to record the time. After 1 hour of extraction, the extract is discharged from the discharge port of the separation t...

Embodiment 2

[0039] 1) First, dry the Xiangzi Michelia leaves naturally, smash them, and pass through a 20-mesh sieve to obtain Xiangzi Michelia leaves powder;

[0040] 2) Set the temperature of the extraction tank to 40℃, the temperature of the separation tank I to 55℃, and the temperature of the separation tank II to 45℃;

[0041] 3) Put the barrel containing 700g of fragrant seed and laugh leaf powder into the extraction tank and add 1L of 90% methanol;

[0042] 4) Start the carbon dioxide circulation system, adjust the pressure of the extraction cylinder to 17.5MPa, the pressure of the separation cylinder I to 12.5MPa, and the pressure of the separation cylinder II to 6MPa. Adjust the mass flow of carbon dioxide corresponding to each kilogram of raw material (Fragrant Seed and Smiling Leaf Powder) to 1.0kg / h. When the temperature and pressure reach the set value, start to record the time, and then respectively after 1h, 2h, 4h, release the extract from the discharge port of the separation ta...

Embodiment 3

[0046] 1) First, dry and smash the Xiangzi Michelia leaves, and pass through a 30-mesh sieve to obtain Xiangzi Michelia leaves powder;

[0047] 2) Set the temperature of the extraction tank to 45℃, the temperature of the separation tank I to 60℃, and the temperature of the separation tank II to 50℃;

[0048] 3) Put the barrel containing 1kg of fragrant seeds and laughing leaf powder into the extraction tank;

[0049] 4) Start the carbon dioxide circulation system, adjust the pressure of the extraction cylinder to 20MPa, the pressure of the separation cylinder I to 15MPa, and the pressure of the separation cylinder II to 6MPa. Adjust the mass flow of carbon dioxide corresponding to each kilogram of raw material (Fragrant Seed and Smiling Leaf Powder) to 1.5kg / h. When the temperature and pressure reach the set value, start to record the time, and then after 1h, 3h, and 5h respectively, release the extract from the discharge port of the separation tank II in three times (extraction tot...

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Abstract

The invention provides a method for extracting parthenolide from a plant raw material, which comprises the following steps: naturally airing collected plant raw material leaves, pulverizing, and screening to obtain leaf powder; and performing carbon dioxide supercritical extraction, stirring the extract with silica gel, passing through a silica gel column based on a dry process, performing gradient elution, and recrystallizing to obtain the parthenolide monomer of which the purity is more than 99%. According to the invention, the parthenolide monomer is extracted through supercritical extraction-silica gel column chromatography-recrystallization; the method has the characteristics that the extraction process is simple, the efficiency is high, the effective components are not destroyed, CO2 gas can be circularly used, a complicated extraction course is not required and the like; and the method can realize comprehensive utilization maximization of the resources, is low in industrial production cost, and has wide application prospects and significant social meanings and economic value.

Description

Technical field [0001] The invention belongs to the technical field of medicine extraction, and specifically relates to a stepwise extraction method of parthenolide. Background technique [0002] Michelia hedyosperma (scientific name: Michelia hedyosperma) is an ornamental plant of the Magnoliaceae genus Michelia, distributed in Hainan (Bawangling in the southeast of Baisha), southwest Guangxi, and Yunnan (Xishuangbanna). The seeds can be used as medicinal and flavoring spices. According to the chemical analysis of Chinese herbal medicine, this genus contains parthenolide, an anti-tumor active ingredient. [0003] Malignant tumors are one of the major diseases that seriously endanger human health and life. The latest statistics published by the World Health Organization (WHO) show that in 2008, there were about 12.7 million new cancer cases and 7.6 million deaths worldwide; about 2.8 million new cancer cases in my country and about 2 million deaths. Cancer has become the leading...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D493/04
CPCC07D493/04Y02P20/54
Inventor 秦向阳李涛何炜刘建强李志全吕凌云
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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