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Traditional Chinese medicine composition containing glossy ganoderma and preparation method of composition

A technology of composition and traditional Chinese medicine, which is applied in the direction of medical preparations containing active ingredients, drug combinations, and medical formulas, can solve problems such as liver damage, metabolic disorders in the body, and high prices of statins, and achieve good curative effect and reliable quality. control effect

Inactive Publication Date: 2014-01-15
TIANJIN TIANSHI BIOLOGICAL DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of drug has a good effect of lowering blood lipids, but long-term use will cause muscle toxicity such as myalgia, muscle inflammation, and even rhabdomyolysis, as well as side effects such as metabolic disorders in the body, gastrointestinal adverse reactions, and liver damage.
At the same time, the price of statins is high, and long-term use will correspondingly increase the economic burden of patients

Method used

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  • Traditional Chinese medicine composition containing glossy ganoderma and preparation method of composition

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] Active components are extracted from the raw materials according to the following parts by weight: 1 part of seabuckthorn, 3 parts of salvia miltiorrhiza, and 1 part of ganoderma lucidum.

[0049] Take seabuckthorn, salvia miltiorrhiza and ganoderma lucidum, grind them, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and extract twice, the first time is 1 hour, the second time is 1 hour, and the filtrates are combined to obtain extract I , add 70% ethanol to the dregs, heat and reflux to extract twice, the first time is 0.5 hours, the second time is 0.5 hours, the filtrates are combined to obtain the extract II, the combined extracts I and II are concentrated into extracts, and dissolved in 50% ethanol Extraction, using macroporous resin AB-8 to separate it, firstly eluted with water to obtain eluent I; then eluted with 50% ethanol, and then eluted with 90% ethanol, the elution flow rate is 1BV / h , to eluate II, recovery, concentration under reduced pre...

Embodiment 2

[0052] Active components are extracted from the raw materials according to the following parts by weight: 25 parts of seabuckthorn, 30 parts of salvia miltiorrhiza, and 3 parts of ganoderma lucidum.

[0053]Take seabuckthorn, salvia miltiorrhiza and Ganoderma lucidum, grind them, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and extract twice, the first time is 3 hours, the second time is 2 hours, and the filtrates are combined to obtain extract I , add 70% ethanol to the dregs, heat and reflux to extract twice, the first time is 1.5 hours, the second time is 1 hour, the filtrates are combined to obtain the extract II, the combined extracts I and II are concentrated into an extract, and dissolved in 50% ethanol Extraction, use macroporous resin X-5 to separate it, first elute with water to get eluent I; then elute with 60% ethanol, then elute with 95% ethanol, the elution flow rate is 4BV / h , to eluate II, recovery, concentration under reduced pressure, dryi...

Embodiment 3

[0056] Active components are extracted from the raw materials according to the following parts by weight: 2 parts of seabuckthorn, 5 parts of salvia miltiorrhiza, and 1 part of ganoderma lucidum.

[0057] Take seabuckthorn, salvia miltiorrhiza and ganoderma lucidum, grind them, add ethyl acetate and 70% ethanol at a volume ratio of 1:2, heat and extract twice, the first time is 1.5 hours, the second time is 1.5 hours, and the filtrates are combined to obtain extract I , add 70% ethanol to the dregs, heat and reflux to extract twice, the first time for 1 hour, the second time for 1 hour, the filtrates are combined to obtain the extract II, the combined extracts I and II are concentrated into an extract, and dissolved in 50% ethanol Extraction, using macroporous resin AB-8 to separate it, firstly eluted with water to obtain eluent I; then eluted with 55% ethanol, and then eluted with 95% ethanol, the elution flow rate is 3BV / h , to eluate II, recovery, concentration under reduce...

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Abstract

The invention discloses a traditional Chinese medicine composition containing glossy ganoderma. The composition comprises the following components in parts by weight: 1-25 parts of sea-buckthorn, 3-30 parts of salvia miltiorrhiza and 1-3 parts of glossy ganoderma. The invention also discloses a preparation method of the traditional Chinese medicine composition. The preparation method comprises the steps of extracting active ingredients and preparing the finished product according to the formula. The traditional Chinese medicine composition makes the best of the treatment effects of active pharmaceutical ingredients on cardiovascular diseases, adopts scientific matching, generates synergistic effects, has better curative effects and more controllable quality than traditional blood lipid reducing medicine preparations and is suitable for industrial production.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating cardiovascular diseases and a preparation method thereof, belonging to the field of traditional Chinese medicines. Background technique [0002] With the continuous improvement of people's living standards, changes in diet structure, population aging is becoming more and more obvious, and the incidence of coronary heart disease is increasing day by day. Coronary heart disease is a heart disease caused by narrowing of the lumen caused by coronary atherosclerosis, which causes myocardial blood supply and oxygen supply disturbance, and is known as the "world killer". As far as the whole world is concerned, coronary heart disease has become one of the most serious diseases threatening human health in the past half century, and it is the main cause of death in the United States and some industrialized countries. According to the statistics of the World Health Organization, 24....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61P3/06
Inventor 崔卜东贾林
Owner TIANJIN TIANSHI BIOLOGICAL DEV
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