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Extraction technology optimization method

An optimization method and extraction process technology, which is applied in the direction of solid solvent extraction, etc., can solve the problems of long extraction process cycle, large labor consumption, high energy consumption, etc., and achieve the effects of reducing extraction times, reducing production costs, and improving production efficiency

Inactive Publication Date: 2014-01-01
INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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  • Abstract
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  • Application Information

AI Technical Summary

Problems solved by technology

[0006] In view of the shortcomings of the current extraction process optimization method, such as long extraction process cycle, high energy consumption, low efficiency, and large labor consumption, the present invention aims to provide a new extraction process optimization method

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach 1

[0015] Study on Optimization of Extraction Process of Panax notoginseng

[0016] Based on the results of orthogonal process optimization reported in the literature (Yuan Xujiang, re-study on the extraction process of notoginseng in compound preparations [J], Chinese Patent Medicine, 2008, 7(30): 1057-159), the dynamic process process optimization was carried out.

[0017] Take Radix Notoginseng 100g (coarse powder, according to the 2010 version "Chinese Pharmacopoeia" standard), add 10 times the amount of 70% ethanol 1000ml, reflux extraction, respectively at 0, 10, 20, 30, 40, 50, 60, 70, 80 , 90, 100, 110, 120, 140, 160, and 180 min, respectively accurately measure 3 ml of the extract for content determination, and make up the same volume of 70% ethanol each time. After 180 minutes, filter the extract, add 1000ml of 70% ethanol to the dregs, and reflux extraction. , 160, and 180 min, respectively accurately measure 3 ml of the extract for content determination, and make up ...

Embodiment approach 2

[0032] Study on Optimization of Extraction Process of Gegen Qinlian Decoction

[0033] Through the investigation of the orthogonal design process, the optimized extraction process of Gegen Qinlian Decoction was determined as follows: 12 times the amount of water, extraction 3 times, 2 hours each time. On this basis, dynamic process optimization

[0034] Weigh 36g of kudzu root, 13.5g of coptis, 13.5g of scutellaria baicalensis, and 9g of roasted licorice, add 12 times the amount of distilled water, and decoct for 2 hours. After boiling: 0min, 10min, 20min, 30min, 40min, 50min, 60min, 70min, 80min, 90min, 100min, 110min, 120min, take about 5ml of the decoction liquid, make up the same volume of solvent each time, let it cool, that is Obtain the dynamic change sample solution for the first extraction.

[0035] After the first decoction, filter while it is hot, then add 12 times the amount of distilled water, and decoct, respectively, after boiling for 0min, 10min, 20min, 30min...

Embodiment approach 3

[0058] Optimization of Extraction Technology of Ganmaozhike Granules

[0059] Based on the 2010 edition of "Pharmacopoeia", according to the extraction process of Ganmao Zhike Granules: 10 times the amount of water, extraction 2 times, 4 hours each time, and dynamic process optimization.

[0060] According to the prescription amount, except for menthol, add 10 times the amount of water to the other eight flavors such as bupleurum, and extract twice, each time for 4 hours. After boiling: 0min, 20min, 40min, 60min, 80min, 100min, 120min, 140min, 160min, 180min, 200min, 220min, 240min, take about 5ml of the decoction liquid, make up the same volume of solvent each time, let it cool, that is Obtain the dynamic change sample solution for the first extraction.

[0061] After the first decoction, filter while it is hot, then add 10 times the amount of distilled water, and decoct. After 240 minutes, take about 5ml of the decoction solution, make up the same volume of solvent each ti...

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Abstract

The invention relates to an optimization method for the extraction time and (or) the times of the extraction in an extraction process. According to the method, the optimizations of the extraction time and (or) the times of the extraction are performed by investigating the change of the amount of the extract during the extraction process. With the method of the present invention, the extraction time can be substantially reduced, the extraction cost can be saved, and the extraction rate and the extraction efficiency can be fully ensured. The method of the present invention can be applicable for extractions of various extracts such as Chinese crude drugs, drugs, natural products, health care products, preparations and the like.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine modernization, in particular to the optimization of extraction process. Background technique [0002] Extraction of traditional Chinese medicine and related products, including extraction of Chinese medicinal materials, extraction of traditional Chinese medicine prescriptions, extraction of health care products, extraction of natural products, extraction of food, etc., is a key step in its industrial production, which is related to the efficacy and production efficiency of products. How to ensure the efficiency of extraction is the main purpose of extraction process optimization. Extraction process optimization often uses methods such as single factor investigation, orthogonal design, and uniform design, among which orthogonal design is the most widely used. In the extraction process optimization process, the investigation of extraction time and extraction times is an importa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D11/02
Inventor 刘安章军王跃生
Owner INST OF CHINESE MATERIA MEDICA CHINA ACAD OF CHINESE MEDICAL SCI
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