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Preparation method of hydroxyapatite microspheres

A technology of hydroxyapatite and microspheres, which is applied in the field of preparation of hydroxyapatite microspheres, can solve the problems of slow reaction process and unfavorable rapid production, and achieve the effects of rapid reaction, pollution avoidance and mild reaction conditions

Inactive Publication Date: 2013-12-25
HANGZHOU DANBINNI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

It is worth pointing out that the two simply use the hydrothermal method, and the reaction time is more than several days, and the reaction process is slow, which is not conducive to rapid industrial production.

Method used

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  • Preparation method of hydroxyapatite microspheres
  • Preparation method of hydroxyapatite microspheres
  • Preparation method of hydroxyapatite microspheres

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] (1) 0.434g disodium hydrogen phosphate (Na 2 HPO 4 12H 2 O) Dissolve in 200ml deionized water to make a phosphate solution.

[0029] (2) Slowly add sodium hydroxide with a concentration of 1 mol / L dropwise to the above solution while stirring until the pH value reaches 10.

[0030] (3) Add 0.2g of calcium carbonate particles to the phosphate solution in step (2), and keep stirring to form a suspension.

[0031] (4) Put the obtained suspension into a microwave oven, adjust the microwave power to 80W, and the reaction time to 15min, and carry out microwave heating reaction.

[0032] (5) Suction filter the reacted solution with a microporous filter membrane with a pore size of 0.1 μm, wash the obtained filter cake with deionized water and absolute ethanol alternately for 3 times each, and then put it into 40 o The hydroxyapatite microspheres were obtained after drying in a constant temperature drying oven in C for 24 hours.

[0033] After testing: the main phase of t...

Embodiment 2

[0035] (1) 1.808g disodium hydrogen phosphate (Na 2 HPO 4 12H 2 O) Dissolve in 200ml deionized water to make a phosphate solution.

[0036] (2) Slowly add 1mol / L sodium hydroxide dropwise to the above solution while stirring until the pH value reaches 10.

[0037] (3) Add 0.2g of calcium carbonate particles to the phosphate solution in step (2), and keep stirring to form a suspension.

[0038] (4) Put the obtained suspension into a microwave oven, adjust the microwave power to 100W, and the reaction time to 5min, and carry out microwave heating reaction.

[0039] (5) Suction filter the heated solution with a microporous filter membrane with a pore size of 0.1 μm, wash the obtained filter cake with deionized water and absolute ethanol alternately for 4 times each, and then put it in a constant temperature drying oven at 40°C After drying for 48 hours, hydroxyapatite microspheres were obtained.

[0040] After testing: the main phase of the microspheres prepared in Example 2...

Embodiment 3

[0042] (1) 3.616g disodium hydrogen phosphate (Na 2 HPO 4 12H 2 O) Dissolve in 200ml deionized water to make a phosphate solution.

[0043] (2) Slowly add 0.1mol / L sodium hydroxide dropwise to the above solution while stirring until the pH value reaches 10.

[0044] (3) Add 0.2g of calcium carbonate particles to the phosphate solution in step (2), and keep stirring to form a suspension.

[0045] (4) Put the obtained suspension into a microwave oven, adjust the microwave power to 60W, and the reaction time to 15min, and carry out microwave heating reaction.

[0046] (5) Suction filter the reacted solution with a microporous filter membrane with a pore size of 0.15 μm, wash the obtained filter cake with deionized water and absolute ethanol alternately for 3 times, and then put it into 60 o The hydroxyapatite microspheres were obtained after drying in a constant temperature drying oven in C for 24 hours.

[0047] After testing: the main phase of the microspheres prepared in E...

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Abstract

The invention discloses a preparation method of hydroxyapatite microspheres. Methods for synthesizing spherical hydroxyapatite at present mainly comprise a secondary granulation molding method and a direct synthesis method, and the secondary granulation molding method has a high cost because of high apparatus requirements, strict reaction conditions and large energy consumption. Particles prepared through the direct synthesis method have a wide particle size distribution and have an irregular morphology. The method disclosed in the invention comprises the following steps: placing spherical calcium carbonate in an aqueous solution of phosphate as a precursor template, carrying out a hydrothermal method and a microwave radiation method, and carrying out an anion exchange reaction to prepare the hydroxyapatite microspheres. The method disclosed in the invention has the characteristics of rapid reaction, simple operation process, no need of template removal and the like. The obtained hydroxyapatite microspheres can be widely used in the biomedical field as an ideal carrier material for drug sustained release.

Description

technical field [0001] The invention belongs to the field of inorganic biomedical materials, and in particular relates to a preparation method of hydroxyapatite microspheres. Background technique [0002] In tissue engineering, microsphere technology is an important technology. Microspheres can be used as carriers for seed cells and drugs, and can also be used in the preparation of tissue engineering scaffolds. Compared with drug loading on stents, microsphere drug loading has the advantages of strong controlled release ability and sequential release of multiple drugs (Cui Daichao, Fan Tianyuan, 2010). In terms of cell culture, it can provide a three-dimensional environment, simulating the growth environment of cells in the body, which is beneficial to the phenotype of cells; in addition, because traditional nanomaterials are easy to aggregate, when the drug is downloaded purely by physical adsorption, the drug loading capacity Limited; while micron-sized spherical inorgan...

Claims

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Application Information

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IPC IPC(8): C01B25/32
Inventor 蔡玉荣刘玉侃孔英
Owner HANGZHOU DANBINNI BIOTECH
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