Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof

A technology for chronic nephritis and proteinuria, applied in drug combinations, pharmaceutical formulas, medical preparations containing active ingredients, etc., to achieve significant curative effect, reduce urine protein quantification, and reduce clinical symptom scores

Active Publication Date: 2015-07-22
SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

"The ancients did not find urinary protein at that time, but from the current point of view, it is speculated that proteinuria in chronic nephritis is closely related to wind evil.

Method used

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  • Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof
  • Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof
  • Traditional Chinese medicine composition for treating chronic nephritis proteinuria as well as preparation method and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Example 1 Granules

[0034] Using the following traditional Chinese medicine raw materials by weight: 5 grams of Astragalus, 5 grams of Zelan, 5 grams of Mirengen, 5 grams of Shiwei, 5 grams of Qingfengteng, and 5 grams of Guijianyu (referring to the daily crude drug dosage), through the following Prepared by the method described above:

[0035] Astragalus, Zelan, Mirengen, Shiwei four herbs, add 8 times the amount of ethanol each time, extract 3 times, extract 1 hour each time, filter, and combine the ethanol extracts; The extraction process of decoction, that is, the green wind vine and ghost arrow feather are soaked in water 8 times for 1 hour each time, extracted three times, the water extract is concentrated to a relative density of 1.08 ~ 1.12 (80 ° C), and then purified. The purification method can be ethanol. Precipitation method, centrifugation method or chitosan clarification method; the above-mentioned ethanol extracts of Astragalus membranaceus, Zelan, Mire...

Embodiment 2

[0036] Example 2 Granules

[0037] The traditional Chinese medicine raw materials in the following weight ratios are used: 60 grams of Astragalus, 30 grams of Zelan, 50 grams of Mirengen, 45 grams of Shiwei, 45 grams of Qingfengteng, and 45 grams of Guijianyu (referring to the daily crude drug dosage). Prepared by the following method:

[0038] Astragalus, Zelan, Mirengen, Shiwei four herbs, add 12 times the amount of ethanol each time, extract 3 times, extract 2 hours each time, filter, and combine the ethanol extracts; The extraction process of decoction, that is, the green vine and the ghost arrow feather are soaked in water 10 times for 2 hours each time, extracted three times, the water extract is concentrated to a relative density of 1.08-1.12 (80 ° C), and then purified. The purification method can be ethanol. Precipitation method, centrifugation method or chitosan clarification method; the above-mentioned ethanol extracts of Astragalus membranaceus, Zelan, Miren root ...

Embodiment 3

[0039] Example 3 Tablets

[0040] The traditional Chinese medicine raw materials in the following weight ratios were used: 10 grams of Astragalus, 10 grams of Zelan, 10 grams of Mirengen, 10 grams of Shiwei, 6 grams of Qingfengteng, and 6 grams of Gui Jianyu (referring to the daily crude drug dosage). Prepared by the following method:

[0041] Astragalus, Zelan, Mirengen, Shiwei four herbs, add 10 times the amount of ethanol each time, extract 3 times, extract 1.5 hours each time, filter, and combine the ethanol extracts; The extraction process of decoction, that is, the green vine and the ghost arrow feather are soaked in 9 times of water for 1.5 hours each time, extracted three times, the water extract is concentrated to a relative density of 1.08-1.12 (80 ° C), and then purified. The purification method can be ethanol. Precipitation method, centrifugation method or chitosan clarification method; the above-mentioned ethanol extracts of Astragalus membranaceus, Zelan, Miren ...

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Abstract

The invention discloses a traditional Chinese medicine composition for treating chronic nephritis proteinuria and a preparation method thereof. According to the traditional Chinese medicine theory that dampness is caused by deficiency, stasis is caused by deficiency and edema is caused by blood stasis as well as the dampness can be overcome by wind, qi and blood can be dredged, the traditional Chinese medicine composition is prepared from the following material medicine components in parts by weight: 5-60 parts of astragalus membranaceus, 5-30 parts of herba lycopi, 5-50 parts of coix seed roots, 5-45 parts of pyrrosia lingua, 5-45 parts of caulis sinomenii and 5-45 parts of euonymus alatus. The traditional Chinese medicine composition disclosed by the invention is clinically proved to have effects of improving clinical symptoms of a chronic nephritis patient, lowering 24-hour urine protein ration, protecting renal function, adjusting renal blood dynamic indexes and cellular immunity, and the like. Qi-blood theory of the traditional Chinese medicine is interpreted by the modern experimental technique. The traditional Chinese medicine composition is safe, effective, cheap, and suitable for long-term use of spleen and kidney qi-deficiency type and damp turbidity stasis obstruction type chronic nephritis patients, and has extensive clinical application value and guiding significance.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition, in particular to a traditional Chinese medicinal composition for treating chronic nephritis proteinuria and a preparation method and application thereof. Background technique [0002] Chronic glomerulonephritis, referred to as chronic nephritis (CGN), is a group of diseases originating from the glomeruli composed of various causes and pathological types. The etiology accounts for about 54.4% in my country. Chronic nephritis has a long course of disease, and the disease is easy to change. Patients are affected to varying degrees in terms of the functional level of the body's various systems, psychological state, and ability to adapt to the social environment. The serious decline of quality of life has become an important factor seriously endangering patients' health and medical expenses. [0003] Urinary protein is t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8994A61K36/899A61P13/12
Inventor 王琛郑平东何立群杨雪军高建东兰天鹰
Owner SHUGUANG HOSPITAL AFFILIATED WITH SHANGHAI UNIV OF T C M
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