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Method for preparing nano drug-carrying capsule-loaded alginate fibers

A nano-drug-loading and seaweed fiber technology, which is applied in the direction of capsule delivery, microcapsules, nanocapsules, etc., can solve the problems of low payload and single drug properties, and achieve the reduction of wound infection, expansion of application fields, and compatibility Good results

Active Publication Date: 2015-05-20
ZHEJIANG SCI-TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to provide a preparation method of seaweed fiber loaded with nano drug-loaded capsules, on the basis of the original excellent performance of seaweed fiber, endow it with new functional activity, and solve the drug payload of the existing drug-loaded fiber Low, single nature of the drug and other issues

Method used

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  • Method for preparing nano drug-carrying capsule-loaded alginate fibers

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred for 1 h in a constant temperature water bath at 50 °C; 200 mL of 200 μg / mL vancomycin hydrochloride aqueous solution was added, and stirred for 2 h in a constant temperature water bath at 50 °C; the mixed solution was placed in an ice water bath, and stood for 24 h , centrifuged at 12000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with vancomycin hydrochloride, with a drug loading capacity of 23%.

[0020] (2) Weigh 10 g of sodium alginate and add it to 275 mL of deionized water, stir and dissolve fully to obtain a sodium alginate solution with a mass concentration of 3.5 %; weigh 0.1 g of calcium alginate nanocapsules loaded wi...

Embodiment 2

[0022] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred for 1 h in a constant temperature water bath at 50 °C; 200 mL of 200 μg / mL ibuprofen solution was added, and stirred for 2 h in a constant temperature water bath at 50 °C to disperse evenly; the mixed solution was placed in an ice water bath, and stood for 24 h, centrifuged at 12000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with ibuprofen, with a drug loading capacity of 36%.

[0023] (2) Weigh 10 g of sodium alginate and add it to 275 mL of deionized water, fully stir and dissolve to obtain a sodium alginate solution with a mass concentration of 3.5 %; weigh 1.5 g of calcium alginate nanocapsules loaded with ibuprofen, add i...

Embodiment 3

[0025] (1) Weigh 10 g of sodium alginate and add it to 750 mL of deionized water, stir in a water bath at 50 °C for 30 min to obtain a uniform sodium alginate solution; add 0.02 mol / L of Ca(OH) dropwise successively 2 solution and 0.03 mol / L NaHCO 3 Each solution was 200 mL, and stirred in a constant temperature water bath at 50 °C for 1 h; adding 100 mL of 200 μg / mL ibuprofen solution, stirred in a constant temperature water bath at 50 °C for 1 h, and then added 100 mL of 200 μg / mL vancomycin hydrochloride , and continue stirring for 1 h; the mixture was placed in an ice-water bath, allowed to stand for 24 h, centrifuged at 12,000 rpm and washed three times with water, and finally freeze-dried to obtain calcium alginate nanocapsules loaded with ibuprofen and vancomycin hydrochloride at the same time. The ibuprofen loading was 31%, and the vancomycin hydrochloride loading was 18%.

[0026] (2) Weigh 10.0 g of sodium alginate and add it to 275 mL of deionized water, stir and d...

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Abstract

The invention discloses a preparation method of seaweed fiber loaded with nano drug-loaded capsules. Nano drug-loaded capsules were prepared with sodium alginate as a matrix; and added to sodium alginate spinning solution; seaweed fibers loaded with drug-loaded nanocapsules were prepared by wet spinning. The invention can reduce the loss of medicine in the spinning process, the medicine is coated in capsules, can effectively prevent medicine denaturation, and can load different kinds of medicines. In addition, the capsules are prepared with sodium alginate as a matrix, which has good interface compatibility with homogeneous fibers, and the drug-loaded capsules are at the nanometer level, which will not affect the spinnability of the alginate spinning solution and the final fiber properties. The invention can be applied to medical materials such as dressings, gauze, bandages, medicated patches, and medicated pads to reduce wound infection and inflammation, stimulate cell proliferation, thereby accelerating wound healing, and is also suitable for local chemotherapy after tumor surgery.

Description

technical field [0001] The invention relates to a method for preparing functional fibers, in particular to a method for preparing seaweed fibers loaded with nano drug-loaded capsules. Background technique [0002] Seaweed fiber is made of sodium alginate extracted from marine brown algae plants, using a solution containing divalent metal cations (except magnesium ions, generally calcium ions) as a coagulation bath, and processed by wet spinning technology A recycled fiber. Seaweed fiber has excellent characteristics such as high hygroscopic gelation, overall easy removal, high oxygen permeability, biocompatibility, and biodegradable absorption. In addition, after seaweed fibers come into contact with wound exudate or blood, Na + / Ca 2+ Ion exchange, releasing Ca 2+ , Accelerate the blood coagulation process, and at the same time form a layer of stable mesh gel on the surface of the wound, create a microenvironment for the wound that is conducive to tissue growth (slightl...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01F9/04D01F1/10A61L15/28A61L15/44A61K45/00A61K9/51A61K47/36
Inventor 姚菊明许国凯刘琳
Owner ZHEJIANG SCI-TECH UNIV
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