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Nervonic acid chemosynthesis method

A chemical synthesis and nervonic acid technology, applied in the field of nervonic acid synthesis, can solve the problems of limited natural resources of nervonic acid and the inability to meet the high content requirements of nervonic acid, and achieve the effects of shortened reaction time, high safety, and mild reaction conditions

Active Publication Date: 2015-06-03
广东固升医药科技有限公司
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Problems solved by technology

[0005] At present, the separation and purification of nut oil can only produce nervonic acid with a content of about 85%, which cannot meet the high content requirements of the market for nervonic acid, and the natural resources of nervonic acid are very limited. Chemical synthesis is the solution to the shortage of natural resources of nervonic acid. important pathway, but so far, there are few domestic and foreign literatures on the chemical synthesis of nervonic acid

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Embodiment Construction

[0020] The present invention will be further described below using the examples, but the present invention is not limited to the examples, as long as it does not deviate from the purpose of the present invention, it should be included in the protection scope of the present invention.

[0021] Step 1, the synthesis of cis-13-docen-1-ol (II):

[0022] Sodium borohydride (NaBH 4 ) 28.35 g (0.75mol), aluminum trichloride (AlCl 3 ) 20.02 g (0.15mol) and zinc chloride (ZnCl 2 ) 6.8 g (0.05 mol), stirring, slowly drop 352.0 g (1 mol) cis-13-docosenoic acid methyl ester (I) under reflux conditions, cool down after the reaction is completed, and slowly pour the reaction mixture into dilute Acidify in hydrochloric acid, extract with ethyl acetate three times, wash the organic phase with saturated sodium bicarbonate solution, dry over anhydrous sodium sulfate, remove the solvent under reduced pressure and distill, collect 291.0 g of fractions at 208~211℃ / 700Pa, and obtain white crystal...

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Abstract

The invention discloses a nervonic acid chemosynthesis method and belongs to the technical field of chemosynthesis. The nervonic acid chemosynthesis method is characterized in that methyl cis-13-docosenoate(erucate) as a raw material is subjected to reduction, chlorination, diethyl malonate condensation and microwave decarboxylation to produce nervonic acid. The nervonic acid chemosynthesis method has the advantages of simple operation, high yield and good product quality.

Description

technical field [0001] The invention belongs to the technical field of chemical synthesis, and in particular relates to a chemical synthesis method for synthesizing nervonic acid. Background technique [0002] Nervous acid is an omega-9 long-chain monoene fatty acid. In terms of structure, the active form of naturally occurring nervonic acid is that the double bonds at the 15th position are all cis. Nervous acid is a physiologically active substance that exists in animal nerve tissue and brain tissue. It was first isolated from shark brain and cow brain. The double-effect magical substance that promotes the regeneration of nerve cells has the function of restoring the activity of nerve endings, promoting the growth and development of nerve cells, and plays an important role in improving the activity of cranial nerves and preventing cranial neurasthenia. Neural acid is mainly used to promote the intellectual development of infants and young children, as well as the preventio...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07C57/03C07C51/38
Inventor 雷泽付正启温晓江木晓云尹新玉张爱华
Owner 广东固升医药科技有限公司
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