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Hydrogel dressing capable of promoting wound healing and preparation method thereof

A wound healing and hydrogel technology, applied in the field of hydrogel dressing and its preparation, can solve the problems of poor air permeability and toxicity, no promotion effect on wound healing, etc., and achieves the effects of high water content, no toxic side effects, and scar inhibition.

Active Publication Date: 2015-03-11
JIANGSU CHANGJIYONG BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the deficiencies of the above-mentioned prior art, the present invention solves the problem that traditional dressings have no promoting effect on wound healing, and solves the problems of poor air permeability and toxicity; non-toxic and harmless polymer materials are selected as the matrix, which has relatively high High biocompatibility, the obtained hydrogel has good mechanical properties, and can maintain proper viscosity, moisture retention, breathability, convenient for patients to use, and can also avoid the pain caused by refueling to patients, effectively promote wound healing, Reduce scar hyperplasia, after irradiation sterilization, the product is completely sterile and does not infect the wound surface

Method used

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  • Hydrogel dressing capable of promoting wound healing and preparation method thereof
  • Hydrogel dressing capable of promoting wound healing and preparation method thereof
  • Hydrogel dressing capable of promoting wound healing and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Main ingredients: glycerin 25%, water 65%, sodium polyacrylate 4.5%, sodium carboxymethylcellulose 5.5%; sodium polyacrylate and sodium carboxymethylcellulose form the skeleton material; excipients: sodium hyaluronate 0.1%, Tartaric acid 0.1%, disodium edetate 0.01%, aluminum glyoxate 0.1%, ethylparaben 0.1%, kaolin 0.5%, lavender essential oil 0.01%, asiaticoside 0.01%; Joint agent, kaolin as filler, lavender essential oil and asiaticoside constitute the essence.

[0032] The mixed system of sodium polyacrylate, sodium carboxymethylcellulose, aluminum glyoxate, kaolin, disodium edetate and ethylparaben is evenly dispersed in glycerin as the oil phase component. Add tartaric acid into water and stir evenly as the water phase component. The oil phase component is added to the water phase component, and then lavender essential oil and asiaticoside are added, and stirred evenly under vacuum condition to obtain a hydrogel solution. The above-mentioned hydrogel solutio...

Embodiment 2

[0034] Main ingredients: glycerin 35%, water 60%, sodium carboxymethyl cellulose 0.5%, sodium polyacrylate 4.5%; sodium polyacrylate and sodium carboxymethyl cellulose form the skeleton material; excipients: sodium hyaluronate 0.3%, Tartaric acid 0.2%, disodium edetate 0.01%, aluminum glycylate 0.1%, ethylparaben 0.2%, crospovidone 1.5%, lavender essential oil 0.01%, arbutin 0.01%; Aluminum is used as a crosslinking agent, crospovidone is used as a filler, and lavender essential oil and arbutin form the essence.

[0035] Sodium polyacrylate, sodium carboxymethyl cellulose, aluminum glycylate, crospovidone, disodium ethylenediamine tetraacetate, and ethylparaben are uniformly dispersed in glycerin as the oil phase components. Add tartaric acid into water and stir evenly as the water phase component. The oil phase component is added to the water phase component, and then lavender essential oil and arbutin are added, and stirred evenly under a vacuum condition to obtain a hydrog...

Embodiment 3

[0037] Main ingredients: 30% glycerin, 60% water, 6.5% sodium polyacrylate, 3.5% povidone K-30; among them, sodium polyacrylate and povidone K-30 form the skeleton material; excipients: sodium hyaluronate 0.5%, Tartaric acid 0.15%, disodium edetate 0.1%, aluminum glycolate 0.2%, ethylparaben 0.2%, crospovidone 0.5%, growth factor 0.01%; wherein aluminum glycolate is a cross-linking agent, The cross-linked povidone is the filler, and the growth factor is the essence component.

[0038] The mixed system of sodium polyacrylate, povidone K-30, aluminum hydroxide, crospovidone, disodium ethylenediamine tetraacetate, and ethylparaben is uniformly dispersed in glycerin as the oil phase component. Add tartaric acid into water and stir evenly as the water phase component. The oil phase component is added to the water phase component, and growth factors are added, and stirred evenly under vacuum conditions to obtain a hydrogel solution. The above-mentioned hydrogel solution is uniform...

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Abstract

The invention discloses a hydrogel dressing capable of promoting wound healing and a preparation method thereof. The hydrogel dressing consists of: by mass, 25-35% of glycerin, 0.1-0.5% of sodium hyaluronate, 5-10% of a skeletal material, 0.1-0.2% of tartrate, 0.01-0.2% of disodium ethylene diamine tetraacetate, 0.1-0.2% of ethylparaben, 0.1-0.4% of a cross-linking agent, 0.5-1.5% of a filler, 0.01-0.1% of an essential component and 60-65% of deionized water. Due to the interaction between an oil phase and a water phase, a compact net structure is formed and water and the essential component are held in a gel, and after solidification and sterilization, the hydrogel dressing capable of promoting wound healing is prepared. The dressing is applicable to postoperative wound nursing of surgery and gynaecology and obstetrics, and helps to make the surface of the wound keep moist, effectively promote wound healing and inhibit scar hyperplasia.

Description

technical field [0001] The invention relates to a hydrogel dressing and a preparation method thereof, in particular to a hydrogel dressing capable of promoting wound healing and a preparation method thereof. Background technique [0002] When treating a patient's wound, it is necessary to cover the wound with a dressing after removing necrotic tissue to prevent bacterial invasion and control water loss. Traditional dressings have a wide range of raw materials, soft texture and low cost. The traditional dressings that are often used clinically are gauze, cotton pads, etc. However, the hemostatic effect of traditional dressings is unsatisfactory and has no moisturizing effect. Although it has a protective effect on the wound surface, it is generally not considered to promote wound healing. For example, bacterial resistance caused by topical application of antibiotics in gauze dressings will make it difficult for infected wounds to heal, and damage to granulation tissue durin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K47/30A61L47/38A61L15/28A61L15/24A61L15/44A61L15/42
Inventor 彭长生吕园园笪利
Owner JIANGSU CHANGJIYONG BIOTECH CO LTD
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