Method for preparing high-water-solubility cydiodine with low cost

Abstract

The invention discloses a method for preparing high-water-solubility cydiodine with a low cost. The method comprises the following steps of: preparing beta-cyclodextrin into an unsaturated solution; dissolving iodine and potassium iodide into an ethanol solution to obtain an iodine solution, wherein the temperature of the iodine solution is not higher than the temperature of the beta-cyclodextrin solution, and the volume of the ethanol solution is not greater than the 30% of the volume of the beta-cyclodextrin solution; slowly adding the iodine solution into the beta-cyclodextrin solution under stirring condition, and naturally cooling to the room temperature under continuous stirring condition; carrying out natural precipitation or centrifugation on the cooled peridium suspension so as to obtain a coating; drying the peridium to be powder at the room temperature or under a low-temperature condition; then putting the cydiodine into a vacuum dry container, and vacuuming, drying and uniformly mixing at 100-200 DEG C so as to obtain the high-water-solubility cydiodine; and at the same time recycling iodine steam. The effective iodine content of the cydiodine prepared by using the method is greater than 16%, the solubility of the cydiodine in 100ml of water at 20 DEG C is greater than 0.2g, the product yield is greater than 95%, and the iodine recycling rate is greater than 99%.

Description

technical field [0001] The invention relates to a low-cost preparation method of highly water-soluble cedi iodine, which belongs to the technical field of pharmacy. Background technique [0002] As a low-cost coating preparation of iodine, cediiodine has the characteristics of high iodine content, good stability and low cost, and has been developed in clinical medicine for more than 20 years. At the same time, iodine disinfectant is one of the species with the greatest consumption and unique disinfection effect. It is the dream of many scientific researchers whether to develop low-cost cedi iodine into disinfectant products. However, cediodine itself is a poorly water-soluble substance, so the product has not been successfully developed into a disinfectant for many years. [0003] There are many patents about cediodine at home and abroad, but the prepared cediodine is all non-water-soluble products. Only the invention patent "Preparation Method of Highly Water-Soluble Cedi...

AI Technical Summary

Problems solved by technology

[0004] 1. The coating rate is low, iodine crystallizes in the coating, and part of the iodine is wasted

[0005] Because high-concentration iodine solution is used during coating, and the temperature of iodine solution and cyclodextrin temperature are not strictly controlled, if the temperature of iodine solution is higher than the temperature of cyclodextrin solution, iodine will crystallize due to the drop in temperature during coating. Crystallization is difficult to be coated, so sublimation occurs when cedi iodine is dried, resulting in a waste of iodine

In addition, if a saturated solution is used for cyclodextrin, when iodine solution is added to the cyclodextrin solution, because the solubility of cyclodextrin in ethanol solution is much lower than that in water, cyclodextrin is also easy to precipitate and crystallize, resulting in a decrease in the coating rate

[0006] 2. Part of β-cyclodextrin is destroyed by iodine

[0007] Since the coating process uses saturated β-cyclodextrin solution and high-concentration iodine solution, and usually reacts at high temperature, high-concentration iodine is easy to destroy the molecular structure of β-cyclodextrin, making the cyclodextrin after coating Yield reduction

[0008] 3. Iodine loss caused by coating drying and dehydration process

[0009] About 1% to 3% of iodine will sublime when the coated cediodine is dried above room temperature and below 60°C, resulting in iodine loss.

[0010] 4. The high temperature treatment process of the coating results in the loss of iodine

[0012] 5. Part of the coating after high temperature treatment is unstable and the product quality is poor

[0013] After high temperature treatment, the water solubility of the product increases, but the stability of the product decreases. After 180 days at room temperature, the iodine content in the product decreases by about 2% to 5% before it can maintain long-term stability. Difference

[0014] 6. Water solubility is still low

[0015] The solubility of the highly water-soluble cedi iodine produced by the above patent is: Dissolve 0.1g in 100ml of water at 20°C (i.e. the iodine concentration after dissolution is about 160mg / L), and the higher concentration cannot reach

[0016] 7. High product cost

[0017] The above problems directly lead to a low total yield of the highly water-soluble product finally prepared by the above patent, about 85% to 90%, the recovery rate of iodine is 90%, and the yield of available iodine after 180 days is about 80%, resulting in the waste of part of the iodine , the water solubility of the product is not high, and the production cost of the product is relatively high