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Pharmaceutical composition of salviae miltiorrhizae extract for treating cardiovascular and cerebrovascular diseases and use thereof

A technology for cardiovascular and cerebrovascular diseases and a composition is applied in the field of pharmaceutical compositions, which can solve the problems of limitations, inability to reflect the compatibility and synergy of multi-component and multi-target points, and inability to exert the overall therapeutic effect of Salvia miltiorrhiza medicinal materials.

Inactive Publication Date: 2013-11-13
SHANDONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] As mentioned above, the salvianolic acid B and tanshinone IIA sodium sulfonate preparations currently in clinical use use the main components of Danshen alone, and the compatibility involved in the above literature is also relatively limited, neither can play the overall therapeutic effect of Danshen medicinal materials , nor can it reflect the compatibility and synergy of multi-components and multi-targets

Method used

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  • Pharmaceutical composition of salviae miltiorrhizae extract for treating cardiovascular and cerebrovascular diseases and use thereof
  • Pharmaceutical composition of salviae miltiorrhizae extract for treating cardiovascular and cerebrovascular diseases and use thereof
  • Pharmaceutical composition of salviae miltiorrhizae extract for treating cardiovascular and cerebrovascular diseases and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] Example 1: Lyophilized preparation of salvianolic acid B, salvianolic acid A and sodium tanshinone IIA sulfonate (5:2:1)

[0111] Get 20g of salvianolic acid B, 8g of salvianolic acid A and 4g of sodium tanshinone IIA sulfonate in Example 1, add 32g of sodium ascorbate and 12.5g of mannitol, dissolve in 350ml of distilled water, and set the volume to 400ml, filter and sterilize, aseptic conditions The next part is packed in 100 vials, freeze-dried, and sealed under nitrogen to obtain the final product.

Embodiment 2

[0112] Example 2: Lyophilized preparation of salvianolic acid B, salvianolic acid A and sodium tanshinone IIA sulfonate (3:1:1)

[0113] Get 21g of salvianolic acid B, 7g of salvianolic acid A and 7g of sodium tanshinone IIA sulfonate in Example 1, add 7.4g of magnesium hydrogen phosphate, 35g of sodium ascorbate, and 12.5g of mannitol, dissolve in 250ml of distilled water, stir for 20 minutes, and constant volume to 300ml, filter out the insoluble matter, sterilize by filtration, subpackage in 100 vials under aseptic conditions, freeze-dry, and seal under nitrogen to obtain the product.

Embodiment 3

[0114] Example 3: Salvianolic acid B, salvianolic acid A and sodium tanshinone IIA sulfonate (9:3:2) freeze-dried powder injection

[0115] Take 18g of salvianolic acid B, 6g of salvianolic acid and 4g of sodium tanshinone IIA sulfonate, add 6g of magnesium hydrogen phosphate, 27g of sodium ascorbate, and 12.5g of mannitol, dissolve them in 250ml of distilled water, stir for 20 minutes, filter out insolubles, filter out sterilized, freeze-dried under aseptic conditions, the newly prepared powdery pharmaceutical composition is divided into 100 vials, sealed under nitrogen, and the product is obtained.

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Abstract

The invention relates to a pharmaceutical composition of salviae miltiorrhizae extract for treating cardiovascular and cerebrovascular diseases and use thereof. The pharmaceutical composition is a combination of danshinolic acid A or danshinolic acid B and tanshinone IIA sodium sulfonate, or a combination of danshinolic acid A, danshinolic acid B and tanshinone IIA or tanshinone IIA sodium sulfonate. The treatment effect of the pharmaceutical composition is better than that of single application of the ingredients on myocardial infarction, the treatment effect of multi-component and multi-target of the traditional Chinese medicine salviae miltiorrhizae is better expressed, and the pharmaceutical composition is used for preparing drugs for treating cardiovascular and cerebrovascular diseases. The pharmaceutical composition can be processed to tablets, capsules, granules, freeze-dried preparations for injection or freeze-dried preparations for injection or powder-injection of carboxylate according to routine production process of pharmaceutics.

Description

[0001] This application is a divisional application of 201210044094.3. technical field [0002] The present invention relates to a pharmaceutical composition of main components of salvia miltiorrhiza extract, in particular to the composition of salvianolic acid A, salvianolic acid B, tanshinone IIA or a chemical modification of tanshinone IIA, sodium tanshinone IIA sulfonate extracted and refined from salvia miltiorrhiza A pharmaceutical composition and use thereof. Background technique [0003] Salvia miltiorrhiza Bge, as a traditional traditional Chinese medicine, was first recorded in "Shen Nong's Materia Medica". Physicians of all dynasties compared Salvia miltiorrhiza to "one taste of salvia miltiorrhiza Bge, the same function as the four substances" ("Siwu" means "Siwu Decoction", Composed of Angelica, Rehmannia, Chuanxiong, and Paeoniae Alba), the magical effect of Danshen can be seen. According to the 2010 edition of Chinese Pharmacopoeia, Salvia miltiorrhiza has th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/58A61P9/10A61K36/537A61K31/216A61K31/343
Inventor 孙隆儒翟光喜朱海林谢婷婷季梅
Owner SHANDONG UNIV
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