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Arctigenin-containing subcutaneous injection and application thereof

A technique of arctigenin and subcutaneous injection, which is applied in the field of medicine, can solve the problems of low bioavailability and large adverse drug reactions, and achieves the effects of simple preparation, easy control and high stability

Inactive Publication Date: 2013-10-23
SHANDONG NEWTIME PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In order to overcome the defects of low bioavailability and large adverse drug reactions of the existing preparations of arctigenin, the present invention provides a subcutaneous injection containing arctigenin, which has high drug safety and bioavailability close to 100%. , has very broad prospects for clinical application

Method used

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  • Arctigenin-containing subcutaneous injection and application thereof
  • Arctigenin-containing subcutaneous injection and application thereof
  • Arctigenin-containing subcutaneous injection and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] Example 1 Arctigenin Subcutaneous Injection

[0016]

[0017]

[0018] Preparation process: Mix the prescribed amount of propylene glycol and ethanol evenly, add arctigenin, stir to dissolve, add the prescribed amount of 0.9% sodium chloride solution, stir evenly, add 0.5% needle, stir with activated carbon, decarbonize, and then pack it. .

Embodiment 2

[0019] Example 2 Arctigenin Subcutaneous Injection

[0020]

[0021] Preparation process: mix the prescribed amount of PEG-400 with ethanol, add arctigenin, stir to dissolve, add 0.9% sodium chloride solution to 10000ml, stir evenly, add 0.5% needle and use activated carbon to stir and decarbonize, then pack it. .

Embodiment 3

[0022] Example 3 Arctigenin Subcutaneous Injection

[0023]

[0024] Preparation process: Mix the prescribed amount of ethanol and Tween-80 evenly, add arctigenin, stir to dissolve, add water for injection to 10000ml, stir evenly, add 0.5% activated carbon for needles, stir for decarbonization, and then pack it.

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Abstract

The invention discloses a new arctigenin-containing preparation and an application thereof, and particularly discloses arctigenin-containing subcutaneous injection and an application thereof in treatment of related diseases, belonging to the field of medicines. When arctigenin is used for subcutaneous injection, the pharmaceutical treatment effect of the arctigenin is obviously superior to the harmaceutical treatment effect of arctigenin used externally and in an intragastric administration manner, the adverse reaction rate caused by the subcutaneous injection is obviously lower than the adverse reaction rate caused by the direct intravenous injection, and the absolute bioavailability of the arctigenin containing subcutaneous injection reaches up to 98.9%; and therefore, the arctigenin containing subcutaneous injection has wide medical application prospect and market prospect.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a new dosage form of arctigenin and its medical application. Background technique [0002] Subcutaneous injection refers to the injection into the soft tissue between the dermis and the muscle. It has the characteristics of less dosage and quick operation. It has become the most mainstream way of administering biological agents. Subcutaneous injection is often used in the following situations: 1) It is used when the drug effect needs to be achieved quickly and oral administration is not possible or suitable. For example, oral insulin is easily destroyed by digestive enzymes in the gastrointestinal tract and loses its effect, while subcutaneous injection can be quickly absorbed. 2) Local anesthesia or preoperative medicine supply. 3) Vaccination. The injection site for subcutaneous injection is usually on the outside of the upper arm, and the general dosage is 1-2ml. Subcutaneo...

Claims

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Application Information

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IPC IPC(8): A61K9/08A61K31/365A61P35/00
Inventor 赵志全赵涛陈凯张峰
Owner SHANDONG NEWTIME PHARMA
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