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Natural pharmaceutical extractive, as well as preparation method and use thereof

A technology of natural medicines and extracts, used in drug combinations, pharmaceutical formulations, antitumor drugs, etc.

Inactive Publication Date: 2013-10-16
石强
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In recent years, with the advent and popularization of chemotherapy drugs such as 5-fluorouracil, taxanes, hydroxycamptothecin, irinotecan, Xeloda, etc., the incidence of chemotherapy-related diarrhea has increased year by year. Treatment can easily lead to dehydration, malnutrition, serum electrolyte disorder, acid-base balance disorder, etc., which not only bring great disadvantages to the recovery of the body, but also bring certain difficulties to periodic chemotherapy. Effective treatment has become an important part of the overall treatment of cancer patients
[0003]Chemotherapy-associated diarrhea, in terms of its clinical manifestations, belongs to the category of "diarrhea" in traditional Chinese medicine. The research on diarrhea in traditional Chinese medicine is remarkable, but at present There is no Chinese patent medicine that can relieve diarrhea and increase efficacy against cancer chemotherapy

Method used

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  • Natural pharmaceutical extractive, as well as preparation method and use thereof

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Experimental program
Comparison scheme
Effect test

Embodiment approach

[0031] The first step: preparation of various extracts

[0032] (1) Preparation of decoction concentrated extract of Alisma tangerine peel

[0033] According to the compatibility ratio of 1:1, take Alisma and tangerine peel, soak in distilled water, heat and decoct, filter, add distilled water to the dregs, soak, decoct, and filter in the same way, mix the two filtrates, heat and concentrate, and filter with ultrafiltration membrane , dried under reduced pressure, that is.

[0034] (2) Preparation of alisol terpene alcohol B acetate

[0035] Percolate Alisma coarse powder with 80% ethanol, recover ethanol to 10%, put the oily extract on a silica gel column, elute with petroleum ether-ethyl acetate at a volume ratio of 10:1, and then use a solvent ratio of 10 : 3 petroleum ether-ethyl acetate elution, thin-layer chromatography detection, collect fractions, obtain crystallization, and then use petroleum ether-ethyl acetate recrystallization, promptly obtains alisol terpene alc...

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Abstract

The invention relates to a natural pharmaceutical extractive, as well as preparation method and use thereof. The natural pharmaceutical extractive comprises concentrated extractive of water decocted alisma-dried orange peel, alisma-terpene alcohol B acetate, and nobiletin according to the proportion of (1-7) : (1-6) : (5-7). The natural pharmaceutical extractive has an excellent curative effect on diarrhea related to cancer chemo-treatment and a synergistic effect on cancer chemo-treatment.

Description

technical field [0001] The present invention relates to a kind of natural medicine extract, more specifically relate to a kind of natural medicine extract that is composed of Alisma tangerine peel water decoction concentrated extract, Alisma terpene alcohol B acetate and nobietin, the natural medicine extract The preparation method and the use of the natural medicine extract in the preparation of medicines for reducing cancer chemotherapy-related diarrhea and synergizing cancer treatment. Background technique [0002] Malignant tumor is one of the main diseases that endanger human survival and health at present. Its treatment methods include surgery, chemotherapy, radiotherapy, and traditional Chinese medicine treatment, and the effect of chemotherapy on tumors is particularly prominent. Chemotherapy drugs used alone or in combination can cause toxic and side effects such as diarrhea in patients. Diarrhea after tumor chemotherapy is also called chemotherapy-associated diar...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/884A61P1/12A61P35/00A61K36/752A61K31/352
Inventor 石强
Owner 石强
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