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Rapid detection method of key indicators in cinobufagin extraction and concentration processes

A key index, concentration process technology, applied in the field of near-infrared rapid detection, can solve problems such as affecting the refining or drying process, uneven quality of traditional Chinese medicine, uncontrollable concentration end point, etc., to reduce batch differences and save manpower and material resources Effect

Inactive Publication Date: 2013-10-02
ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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Problems solved by technology

Conventional concentration process control is mainly based on empirical methods, lacks fast and effective online monitoring methods, and the uncontrollability of concentration end point determination has become an important factor affecting the quality of traditional Chinese medicine, which directly affects the subsequent refining or drying process.

Method used

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  • Rapid detection method of key indicators in cinobufagin extraction and concentration processes
  • Rapid detection method of key indicators in cinobufagin extraction and concentration processes
  • Rapid detection method of key indicators in cinobufagin extraction and concentration processes

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Embodiment

[0036] 1. Collection of calibration set samples

[0037] Toad skin medicinal materials were soaked in 8 times the amount of purified water for 1 hour, then decocted for 1 hour, the medicinal residues were added with 4 times the amount of purified water, decocted for 45 minutes, and the two extracts were combined. When the cinobufacini extract is completely input into the single-effect concentration tank and reaches the appropriate concentration temperature and pressure (0.04-0.08 Mpa), it is used as the timer zero point, and samples are taken every ten minutes. Eliminate the effect of vacuum by opening and closing the upper and lower hand valves (connecting pipes between the heating chamber and the evaporation chamber) to obtain concentrated samples, see figure 1 . During the concentration process, hand valve 1 and hand valve 2 are closed at the same time. When sampling, first open hand valve 1, and after 10 seconds, the concentrate fills the liquid storage tube, close hand...

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Abstract

The invention relates to a rapid detection method of key indicators in cinobufagin extraction and concentration processes. The rapid detection method comprises the following steps of: (1) collecting cinobufagin extracting concentrates obtained in the extraction and concentration processes in different batches as calibration set samples; (2) respectively determining the key indicators of concentrate samples by adopting a conventional analysis method, including the indole alkaloids concentration, moisture content and density; (3) collecting near infrared spectrograms of the calibration set samples; (4) selecting an appropriate spectrum band and a pre-processing method to obtain spectrum information of cinobufagin concentrate characteristics, and establishing calibration models between the near infrared spectrums and the corresponding key indicators; (5) collecting near infrared spectrograms under the same conditions by taking the concentrate samples with the known key indicator values as a validation set, and leading the collected near infrared spectrograms in the established calibration models, wherein the requirement on the measurement error value is less than 20%; (6) leading near infrared spectrum data of unknown samples into the established calibration models to obtain forecasting information of all the key indicators.

Description

technical field [0001] The invention belongs to the field of near-infrared rapid detection, and in particular relates to a rapid detection method for key indicators in the extraction and concentration process of cinobufacini. Background technique [0002] Cinobufacin injection is a sterilized aqueous solution made from dried toad skin. It has the functions of reducing swelling, analgesia and detoxification. It is mainly used for the treatment of middle and advanced stage tumors, chronic hepatitis B and other diseases. It can also be used for acute hemorrhage. Disseminated pulmonary tuberculosis, epidemic hemorrhagic fever, intractable hiccups and children with mumps complicated by meningitis embolism. Due to its good anti-cancer effect, Cinobufasu injection is currently listed as a national basic medical insurance drug category A and a national Chinese medicine protected species. [0003] The production process of Cinobufasu injection consists of extraction, concentration, ...

Claims

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Application Information

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IPC IPC(8): G01N21/31
Inventor 高波罗川种振刘雪松吴永江金叶
Owner ANHUI CHINA RESOURCES JINCHAN PHARMA CO LTD
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